A Morphologic Classification of Hemopoietic Tumors, Rats

Harleman, Johannes H.; Jahn, W

doi:10.1007/978-3-642-84110-1_24

Cited by 5 publications

(9 citation statements)

References 10 publications

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“…Granulocytic Leukemia: Neoplasms of granulocytes (Figure 47) and their precursors are not as common as lymphoid neoplasms. Granulocytic leukemia may be relatively common in some strains of old rats (Harleman and Jahn, 1990). It has a spontaneous rate of occurrence in C3H/He mice of up to 1% (Seki and Inoue, 1990) while it is extremely rare in other strains.…”

Section: Neoplastic Lesionsmentioning

confidence: 99%

Histopathology of the Spleen

2006

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The spleen contains hematopoietic and lymphoid elements, is a primary site of extramedullary hematopoiesis, and removes degenerate and aged red blood cells as well as particulate materials and circulating bacteria from the blood supply. Lesions of this important component of the immune system may center on the red pulp, the white pulp or involve both compartments The spleen is the site of direct and indirect toxicity, a target for some carcinogens, and also a site for metastatic neoplasia. Many systemic or generalized diseases have splenic involvement. This paper documents spontaneous background and treatment-induced lesions seen in rodent toxicity and carcinogenicity studies.

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Section: Neoplastic Lesionsmentioning

confidence: 99%

Histopathology of the Spleen

2006

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“…Erythroleukemia in rats is an apparently rare hematopoietic neoplasm that is not included as an entity in Frith's classification of the tumors in the SD rat (4,9). Therefore, this report may represent thefirsterythroleukemia occurring naturally in a rat.…”

mentioning

confidence: 99%

“…Erythroleukemia, also referred to as erythroid leukemia (9), is a myeloproliferative disorder that is characterized by excessive proliferation of both erythrocytic and granulocytic cell lines (1 2, 13). In cats and mice, erythroleukemia can be readily induced by oncogenic viruses (1 , 2).…”

mentioning

confidence: 99%

Spontaneous Erythroleukemia in a 16-Wk-Old Female Slc:SD Rat

et al. 1993

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“…7,19,29,31,[33][34][35]46 We also consider the mixed cellular pattern and predominantly pulmonary distribution of the lymphoma type most frequently diagnosed in these bioassays to be uncharacteristic of lymphoma in rats (http://www.toxpath.org/ssdnc/ HemolyphaticProliferativeR.pdf). 6,[11][12][13][14]23,32,44,45 For these reasons, we consider it likely that these bioassays were confounded by M. pulmonis disease and suggest that a plausible alternative explanation for the reported results is that M. pulmonis disease interfered with accurate diagnosis and that lesions of the disease were interpreted as lymphoma.…”

Section: Conflict Of Interest Statementmentioning

confidence: 99%

Mycoplasma pulmonis and Lymphoma in Bioassays in Rats

et al. 2009

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Abstract. Lymphomas were reported to be induced in rats in bioassays of aspartame, methyltertiary-butyl ether (MTBE), and other chemicals conducted by a nonprofit cancer research organization. European regulatory authorities concluded that lymphomas in the aspartame study were caused by Mycoplasma pulmonis and suggested that this also was the case for the MTBE bioassay. To assess the role of M. pulmonis in these bioassays, we reviewed the tumor data for the aspartame and MTBE bioassays and, additionally, the organization's bioassay of methanol. For all 3 studies, the most frequently reported hematopoietic neoplasm was lympho-immunoblastic lymphoma, the most frequently affected organ was the lung, and, in almost half of the rats with this diagnosis, the lung was the only affected organ. Lesions diagnosed as lymphoma in published illustrations had pleomorphic cellular morphology and appeared to contain neutrophils. Information from these reports and other sources indicated that lesions typical of M. pulmonis disease were prevalent among the aspartame and MTBE study rats and that the rats were not specific-pathogen-free. Because the lymphoma type, cellular morphology, and organ distribution reported in these studies are atypical of lymphoma in rats, because lymphocyte and plasma cell accumulation in the lung is characteristic of M. pulmonis disease, and because M. pulmonis disease can be exacerbated by experimental manipulations, including chemical treatment, we suggest that a plausible alternative explanation for the reported results of these bioassays is that the studies were confounded by M. pulmonis disease and that lesions of the disease were interpreted as lymphoma.

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A Morphologic Classification of Hemopoietic Tumors, Rats

Cited by 5 publications

References 10 publications

Histopathology of the Spleen

Histopathology of the Spleen

Spontaneous Erythroleukemia in a 16-Wk-Old Female Slc:SD Rat

Mycoplasma pulmonis and Lymphoma in Bioassays in Rats

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