Australian hospitals need to be prepared to deal with mass casualties from terrorist strikes, including bomb blasts and chemical, biological and radiation injury.• Injuries from bomb explosions are more severe than those commonly seen in Australian hospitals.• Hospitals require well developed standard operating procedures for mass casualty events, reinforced by regular drills.• Preparing for a major event includes training staff in major incident management, setting up an operational/control unit, nominating key personnel, ensuring there is an efficient intra-hospital communication system, and enhancing links MJA 2005; 183: 567-570 with other emergency services and hospitals.