A Multifunctional Origami Patch for Minimally Invasive Tissue Sealing

Wu, Sarah; Yuk, Hyunwoo; Wu, Jingjing; Nabzdyk, Christoph S.; Zhao, Xuanhe

doi:10.1002/adma.202007667

Cited by 103 publications

(105 citation statements)

References 42 publications

Supporting

Mentioning

105

Contrasting

Order By: Relevance

“…However, those carboxyl-containing hydrogels lacking interfacial liquid management were unreliable in physiological salt conditions because of the dissociation of carboxyl hydrogen bonds in a higher pH. [37] Relying on rapid adsorption of interfacial water, a dry tape was capable of quickly physically cross-linking to wet tissues [23] (Figure 2a) but showed a significant decline in adhesion energy. [38,39] To enhance the wet adhesion for hydrogen bonds, Cui et al developed a Janus hydrogel where a gradient decreased polyelectrolyte complexation distribution ranging from a completely neutralized carboxyl layer to less exists.…”

Section: Hydrogen Bond Adhesionmentioning

confidence: 99%

Recent Advances on Designs and Applications of Hydrogel Adhesives

Liu

Wang

et al. 2021

Adv Materials Inter

View full text Add to dashboard Cite

extracellular matrix properties, gives them popularity in applications ranging from drug delivery, [4,5] wound dressing, [6][7][8] and tissue repair. [9,10] Various hydrogels with extraordinary properties have been reported, like tough, [11] stimuliresponse, [12] and optical variable hydrogels. [13] For example, the combination of covalently and ionically cross-linked networks endows hydrogel's excellent mechanical properties, achieving a value of 9000 J m −2 , which is comparable to natural rubber (10 000 J m −2 ). [11] Moreover, hydrogels with "self-growing" property [14] can stand duplicated stretch without ruption but gain a gradual increase in stress instead. However, in contrast to the bulk hydrogel, existing hydrogel adhesives are far from the desired properties. [15] The adhesion energy of commercial adhesives is usually ≈10 J m −2 compared to that of cartilage, composing a robust matrix of 1000 J m −2 and the adhesive layer of 800 J m −2 , respectively. [16] It is worth noting that medical and clinic adhesives should effectively prevent blood loss, gas, and tissue fluids leakage or exposure to the infectious environment or digestive fluids. [17] Thus, adhesion failure ought to result in negative therapy. Adhesion conductive hydrogels are also required to get skinlevel sensitive sensors since any interfacial vacant space will give rise to inaccurate signals. [18,19] As a result, sensors with high resolution and excellent accuracy can not be obtained under such circumstances due to "dead" regions. [20] Therefore, tough interactions between hydrogels matrix and diverse substrate, especially for wet tissues, are vital but challenging issues. [15] Of particularly significant and ideal properties for tough adhesives under stretching, dissipative energy within hydrogel matrix and interactive energy between interfaces is desired to prevent macroscopic movement. [21] By enhancing interfacial interactions via surface chemical modification, surface structuralizing, physical interlocks, or combining the principles mentioned above, a series of adhesive patches or tough adhesives with injectable, tunable curing time, degradable properties have been obtained.Numerous synthetic or natural materials, diverse design strategies, various methods, and many potential applications have emerged. In this review, as shown in Figure 1, we will summarize the state-of-art hydrogel adhesives spanning from design principles, including physical and chemical interactions In virtue of extracellular features, hydrogels have been used in various areas such as tissue repair, artificial skins, and biological electronics, etc. Intact contact of tough hydrogels to targeted surfaces is usually required to avoid blood or body fluids leakage or inaccurate signals of sensors. The collaboration of high interactive energy between interfaces and high fracture toughness of the constituent hydrogels can effectively prevent relatively macroscopic motions of adhesives from substrates under deformation. Nevertheless, variations in surface microenvironment...

show abstract

Section: Hydrogen Bond Adhesionmentioning

confidence: 99%

Recent Advances on Designs and Applications of Hydrogel Adhesives

Liu

Wang

et al. 2021

Adv Materials Inter

View full text Add to dashboard Cite

show abstract

“…Antibiotic release Thiolated chitosan with poly(N-isopropyl acrylamide) loaded with ciprofloxacin [62] Poly(lactic-co-glycolic acid) (PLGA), poly(β-amino esters) (PAE), fibroblast growth factor (bFGF), and ceftriaxone sodium (CTX) [63] Hyaluronic acid (HA), dopamine, doxycycline, and reduced graphene oxide (rGO) [64] Introducing metal nanoparticles Silk fibroin (SF), tannic acid (TA), and silver nanoparticles (AgNPs) [65] Introducing cationic functional group Polyethylenimine (PEI) and polydextran aldehyde (PDA) [66] N-(2-hydroxypropyl)-3-trimethylammonium chitosan chloride (HTCC) and PDA [67] Incroporating organic acids 10-undecylenic acid (UA), poly (ethylene glycol) (PEG), and L-dopamine [68] Preventing microbial adhesion Carbopol (C), cellulose acetate, and perfluorocarbon liquid [69] Polyurethane (PU), chitosan, polysulfobetaines, and siliconje oil [70] Cell-infiltrative Introducing reversible crosslinks PEG and LAPONITE [70] Dopamine modified PEG (PEGDA) and gelatin microgel [71] Gelatin and β-cyclodextrin (β-CD) [72] Increasing pore size Silica microparticle and PEGDA [73] Electrically conductive…”

Section: Antimicrobialmentioning

confidence: 99%

“…Wu et al developed a multilayer bioadhesive patch consisting of an adhesive layer, blood-repellent hydrophobic layer, and antifouling zwitterionic layer (Figure 6A-i). [70] The adhesive layer was based on a double network of poly(acrylic acid) grafted with NHS ester (PAA-NHS ester) and chitosan. The PAA-NHS ester allows stable wet adhesion.…”

Section: Materials Referencementioning

confidence: 99%

See 1 more Smart Citation

Rational engineering and applications of functional bioadhesives in biomedical engineering

Park

Kim

Chun

et al. 2021

Biotechnology Journal

View full text Add to dashboard Cite

For the past decades, several bioadhesives have been developed to replace conventional wound closure medical tools such as sutures, staples, and clips. The bioadhesives are easy to use and can minimize tissue damage. They are designed to provide strong adhesion with stable mechanical support on tissue surfaces. However, this monofunctionality of the bioadhesives hinders their practical applications. In particular, a bioadhesive can lose its intended function under harsh tissue environments or delay tissue regeneration during wound healing. Based on several natural and synthetic biomaterials, functional bioadhesives have been developed to overcome the aforementioned limitations. The functional bioadhesives are designed to have specific characteristics such as antimicrobial, cell infiltrative, stimuli-responsive, electrically conductive, and self-healing to ensure stability under harsh tissue conditions, facilitate tissue regeneration, and effectively monitor biosignals. Herein, we thoroughly review the functional bioadhesives from their fundamental background to recent progress with their practical applications for the enhancement of tissue healing and effective biosignal sensing.Furthermore, the future perspectives on the applications of functional bioadhesives and current challenges in their commercialization are also discussed.

show abstract

“…nature-inspired strategies, including 3,4-dihydroxyphenyl-Lalanine (DOPA)-modified adhesives, biomimetic protein adhesives, and structure-inspired adhesives. [1][2][3][4] Owing to the stable and robust properties of wet/underwater adhesion to various substrates, these materials are playing vital roles of tissue adhesion, 5,6 biomedical coatings, 7 drug-delivery systems, 8 and even energy field. 9 Traditional commercially available adhesives, such as epoxy resins, 10 polyurethanes 11 and cyanoacrylate-based adhesives 12,13 have been used extensively under wet conditions but have several drawbacks, such as a long curing time, an unstable adhesive force, lack of reusability, and biological toxicity.…”

mentioning

confidence: 99%

Mechanisms and applications of bioinspired underwater/wet adhesives

Cai

Жен

Chen

et al. 2021

Journal of Polymer Science

View full text Add to dashboard Cite

In nature, many organisms can effectively fix to contact substrates and move and prey in complex living environments, such as underwater, seawater, and tidal environments, owing to special secreted chemical components and/or special micro/nanostructures on the adhesive surface of these organisms.Inspired by the adhesive performance of organisms, extensive research related to adhesive components and adhesive surfaces has been conducted recently.To better understand the underlying adhesive mechanisms and facilitate further continuous inspiration, a brief overview of recent wet/underwater adhesive materials is provided herein. First, the adhesive processes and underlying mechanisms of commonly researched organisms, such as mussels, octopuses, clingfish, and tree frogs, are discussed, and the corresponding bioinspired artificial adhesives are presented. Then, the applications of these bioinspired adhesives, such as intelligent robots (signal monitoring and sensing devices), wearable devices (including wet climbing and electronic skin), biomedicines (including wound dressings, bone adhesion, and rapid hemostasis), are presented and summarized. Finally, we offer our perspective on the future challenges and development of bioinspired artificial adhesives. K E Y W O R D S adhesive surfaces, applications, artificial components, natural organisms 1 | INTRODUCTION Recently, the development of wet/underwater adhesives inspired by natural organisms has attracted increasing attention and achieved significant progress based on various Chao Cai and Zhen Chen contributed equally to this work

show abstract

A Multifunctional Origami Patch for Minimally Invasive Tissue Sealing

Cited by 103 publications

References 42 publications

Recent Advances on Designs and Applications of Hydrogel Adhesives

Recent Advances on Designs and Applications of Hydrogel Adhesives

Rational engineering and applications of functional bioadhesives in biomedical engineering

Mechanisms and applications of bioinspired underwater/wet adhesives

Contact Info

Product

Resources

About