A Multiphysic Model for the Hyperthermia Treatment of Residual Osteosarcoma Cells in Upper Limbs Using Magnetic Scaffolds

Lodi, Matteo Bruno; Fanti, Alessandro; Muntoni, Giacomo; Mazzarella, Giuseppe

doi:10.1109/jmmct.2019.2959585

Cited by 39 publications

(82 citation statements)

References 62 publications

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“…Consequently, the classical Debye model of the classical Linear Response Theory [ 79 ] used for the description of MNP relaxation dynamics is no longer valid. An extension of this model by considering a distribution of relaxation times, the so-called Cole–Cole model, was proposed to describe the relaxation phenomena of MNP inside magnetic scaffolds [ 41 , 43 ]. The ACS results in Figure 6 qualitatively describe the MNP relaxation behavior according to the Cole–Cole model.…”

Section: Resultsmentioning

confidence: 99%

“…As previously reported for magnetic scaffolds, the heating perfomence of the hybrid stents is strongly influenced by the change in magnetic relaxation dynamics due to interparticle interactions and blocking of the Brownian relaxation. To describe the relaxation dynamics of MNP in magnetic scaffolds, the Cole–Cole model was proposed [ 41 , 42 , 43 ]. Moreover, for a deeper understanding of the fundamentals of the magnetic relaxation processes of MNP and prediction of the heating efficiency of MNP inside hybrid materials, non-equilibrium stochastic simulations of the relaxtions dymanics proved to be a powerful tool [ 46 , 47 ].…”

Section: Resultsmentioning

confidence: 99%

“…However, they lack comprehensive implementation of MNP dynamic relaxation processes. To account for the interaction phenomena and the absence of the Brownian relaxation in magnetic scaffolds, the so-called Cole–Cole model, an extension of the Debye model used in the LRT, was suggested for the description of the relaxation dynamics [ 41 , 42 , 43 ]. With this model, the temperature increase of magnetic scaffolds activated in an AMF was explained based on a smooth decrease of MNP susceptibility for increasing frequency.…”

Section: Introductionmentioning

confidence: 99%

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Nanomagnetic Actuation of Hybrid Stents for Hyperthermia Treatment of Hollow Organ Tumors

et al. 2021

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This paper describes a magnetic nanotechnology that locally enables hyperthermia treatment of hollow organ tumors by using polymer hybrid stents with incorporated magnetic nanoparticles (MNP). The hybrid stents are implanted and activated in an alternating magnetic field to generate therapeutically effective heat, thereby destroying the tumor. Here, we demonstrate the feasibility of nanomagnetic actuation of three prototype hybrid stents for hyperthermia treatment of hollow organ tumors. The results show that the heating efficiency of stent filaments increases with frequency from approximately 60 W/gFe (95 kHz) to approximately 250 W/gFe (270 kHz). The same trend is observed for the variation of magnetic field amplitude; however, heating efficiency saturates at approximately 30 kA/m. MNP immobilization strongly influences heating efficiency showing a relative difference in heating output of up to 60% compared to that of freely dispersed MNP. The stents showed uniformly distributed heat on their surface reaching therapeutically effective temperatures of 43 °C and were tested in an explanted pig bile duct for their biological safety. Nanomagnetic actuation of hybrid stents opens new possibilities in cancer treatment of hollow organ tumors.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Nanomagnetic Actuation of Hybrid Stents for Hyperthermia Treatment of Hollow Organ Tumors

et al. 2021

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“…In this study, we focused on tumor-bearing frozen autograft as a treatment strategy for metastatic bone tumors. On the other hand, new treatment strategies for metastatic bone tumors, such as hyperthermia, have been also reported [ 54 , 55 ]. Hyperthermia of bone tumors is a promising strategy for controlling recurrence and reduces surgical side-effects, in particular, when magnetic biomaterials are used as prosthetic implants and grafts.…”

Section: Discussionmentioning

confidence: 99%

Abscopal Effect of Frozen Autograft Reconstruction Combined with an Immune Checkpoint Inhibitor Analyzed Using a Metastatic Bone Tumor Model

Yonezawa

Murakami

Demura

et al. 2021

IJMS

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We evaluated the abscopal effect of re-implantation of liquid nitrogen-treated tumor-bearing bone grafts and the synergistic effect of anti-PD-1 (programmed death-1) therapy using a bone metastasis model, created by injecting MMT-060562 cells into the bilateral tibiae of 6–8-week-old female C3H mice. After 2 weeks, the lateral tumors were treated by excision, cryotreatment using liquid nitrogen, excision with anti-PD-1 treatment, and cryotreatment with anti-PD-1 treatment. Anti-mouse PD-1 4H2 was injected on days 1, 6, 12, and 18 post-treatment. The mice were euthanized after 3 weeks; the abscopal effect was evaluated by focusing on growth inhibition of the abscopal tumor. The re-implantation of frozen autografts significantly inhibited the growth of the remaining abscopal tumors. However, a more potent abscopal effect was observed in the anti-PD-1 antibody group. The number of CD8+ T cells infiltrating the abscopal tumor and tumor-specific interferon-γ (IFN-γ)-producing spleen cells increased in the liquid nitrogen-treated group compared with those in the excision group, with no significant difference. The number was significantly higher in the anti-PD-1 antibody-treated group than in the non-treated group. Overall, re-implantation of tumor-bearing frozen autograft has an abscopal effect on abscopal tumor growth, although re-implantation of liquid nitrogen-treated bone grafts did not induce a strong T-cell response or tumor-suppressive effect.

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“…In order to eliminate the ”hot spots” and separate them from the treated tissue, boluses with cold water or hydrogels placed between the applicator and the tissue might be employed [ 27 ]. The concentration of EM energy in the cancerous area can also be obtained after placing magnetic nanoparticles (MNPs) within the tumor; however, in such cases, due to the safety procedures, much lower frequencies should be applied [ 28 , 29 , 30 , 31 , 32 , 33 ]. Importantly, various minimally invasive techniques for hyperthermic or ablative heating of tumors require continuous intensive research, with a concentrated effort by scientists to improve their effectiveness in uniform heating of the ROI and reducing possible side effects [ 34 ].…”

Section: Introductionmentioning

confidence: 99%

In Silico Study on Tumor-Size-Dependent Thermal Profiles inside an Anthropomorphic Female Breast Phantom Subjected to Multi-Dipole Antenna Array

Gas

Miaskowski

Subramanian

2020

IJMS

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Electromagnetic hyperthermia as a potent adjuvant for conventional cancer therapies can be considered valuable in modern oncology, as its task is to thermally destroy cancer cells exposed to high-frequency electromagnetic fields. Hyperthermia treatment planning based on computer in silico simulations has the potential to improve the localized heating of breast tissues through the use of the phased-array dipole applicators. Herein, we intended to improve our understanding of temperature estimation in an anatomically accurate female breast phantom embedded with a tumor, particularly when it is exposed to an eight-element dipole antenna matrix surrounding the breast tissues. The Maxwell equations coupled with the modified Pennes’ bioheat equation was solved in the modelled breast tissues using the finite-difference time-domain (FDTD) engine. The microwave (MW) applicators around the object were modelled with shortened half-wavelength dipole antennas operating at the same 1 GHz frequency, but with different input power and phases for the dipole sources. The total input power of an eight-dipole antenna matrix was set at 8 W so that the temperature in the breast tumor did not exceed 42 °C. Finding the optimal setting for each dipole antenna from the matrix was our primary objective. Such a procedure should form the basis of any successful hyperthermia treatment planning. We applied the algorithm of multi for multi-objective optimization for the power and phases for the dipole sources in terms of maximizing the specific absorption rate (SAR) parameter inside the breast tumor while minimizing this parameter in the healthy tissues. Electro-thermal simulations were performed for tumors of different radii to confirm the reliable operation of the given optimization procedure. In the next step, thermal profiles for tumors of various sizes were calculated for the optimal parameters of dipole sources. The computed results showed that larger tumors heated better than smaller tumors; however, the procedure worked well regardless of the tumor size. This verifies the effectiveness of the applied optimization method, regardless of the various stages of breast tumor development.

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A Multiphysic Model for the Hyperthermia Treatment of Residual Osteosarcoma Cells in Upper Limbs Using Magnetic Scaffolds

Cited by 39 publications

References 62 publications

Nanomagnetic Actuation of Hybrid Stents for Hyperthermia Treatment of Hollow Organ Tumors

Nanomagnetic Actuation of Hybrid Stents for Hyperthermia Treatment of Hollow Organ Tumors

Abscopal Effect of Frozen Autograft Reconstruction Combined with an Immune Checkpoint Inhibitor Analyzed Using a Metastatic Bone Tumor Model

In Silico Study on Tumor-Size-Dependent Thermal Profiles inside an Anthropomorphic Female Breast Phantom Subjected to Multi-Dipole Antenna Array

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