A multipurpose conjugated polymer: Electrochromic device and biosensor construction for glucose detection

Söylemez, Saniye; Kaya, Hava Zekiye; Udum, Yasemin Arslan; Toppare, Levent

doi:10.1016/j.orgel.2018.11.001

Cited by 44 publications

(19 citation statements)

References 34 publications

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“…For example, a cobalt single-atom catalyst coated glassy carbon electrode was used to detect the oxidation of H 2 O 2 from a glucose sensor at only +0.2 V, a −0.5 V shift from the standard oxidation potential used for amperometric detection of H 2 O 2 [ 124 ]. Conducting polymers such as poly(2,5-di(furan-2-yl)thiazolo[5,4- d ]thiazole)(PTTzFr) or electroactive Schiff based polymers with 2D near-single-atom thickness were also reported to help immobilize glucose oxidase (GOx) and detect the catalyzed oxygen reduction with good stability [ 125 , 126 ].…”

Section: Electrochemical Sensorsmentioning

confidence: 99%

Recent Advances in In Vivo Neurochemical Monitoring

Tan

Robbins

et al. 2021

Micromachines

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The brain is a complex network that accounts for only 5% of human mass but consumes 20% of our energy. Uncovering the mysteries of the brain’s functions in motion, memory, learning, behavior, and mental health remains a hot but challenging topic. Neurochemicals in the brain, such as neurotransmitters, neuromodulators, gliotransmitters, hormones, and metabolism substrates and products, play vital roles in mediating and modulating normal brain function, and their abnormal release or imbalanced concentrations can cause various diseases, such as epilepsy, Alzheimer’s disease, and Parkinson’s disease. A wide range of techniques have been used to probe the concentrations of neurochemicals under normal, stimulated, diseased, and drug-induced conditions in order to understand the neurochemistry of drug mechanisms and develop diagnostic tools or therapies. Recent advancements in detection methods, device fabrication, and new materials have resulted in the development of neurochemical sensors with improved performance. However, direct in vivo measurements require a robust sensor that is highly sensitive and selective with minimal fouling and reduced inflammatory foreign body responses. Here, we review recent advances in neurochemical sensor development for in vivo studies, with a focus on electrochemical and optical probes. Other alternative methods are also compared. We discuss in detail the in vivo challenges for these methods and provide an outlook for future directions.

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Section: Electrochemical Sensorsmentioning

confidence: 99%

Recent Advances in In Vivo Neurochemical Monitoring

Tan

Robbins

et al. 2021

Micromachines

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“…Donor-acceptor CPs, containing electron donor and acceptor repeat units, exhibit efficient electrochromic switching, and applications in OFETs and solar cells (Soylemez et al, 2019), and also possess biosensing capabilities. Soylemez et al (2019) synthesized a donor-acceptor CP ( 6 ) containing furan (donor) and thiazole (acceptor) moieties in a “proof-of-concept” glucose biosensor. The monomer, 2,5-di(furan-2-yl)thiazolo[5,4-d]thiazole, was synthesized in a mild, single-step reaction and underwent CV electropolymerization onto a graphite electrode.…”

Section: Organic Semiconducting Polymers For Electrochemical Biosensorsmentioning

confidence: 99%

All-Organic Semiconductors for Electrochemical Biosensors: An Overview of Recent Progress in Material Design

Hopkins

Fidanovski

Lauto

et al. 2019

Front. Bioeng. Biotechnol.

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Organic semiconductors remain of major interest in the field of bioelectrochemistry for their versatility in chemical and electrochemical behavior. These materials have been tailored using organic synthesis for use in cell stimulation, sustainable energy production, and in biosensors. Recent progress in the field of fully organic semiconductor biosensors is outlined in this review, with a particular emphasis on the synthetic tailoring of these semiconductors for their intended application. Biosensors ultimately function on the basis of a physical, optical or electrochemical change which occurs in the active material when it encounters the target analyte. Electrochemical biosensors are becoming increasingly popular among organic semiconductor biosensors, owing to their good detection performances, and simple operation. The analyte either interacts directly with the semiconductor material in a redox process or undergoes a redox process with a moiety such as an enzyme attached to the semiconductor material. The electrochemical signal is then transduced through the semiconductor material. The most recent examples of organic semiconductor biosensors are discussed here with reference to the material design of polymers with semiconducting backbones, specifically conjugated polymers, and polymer semiconducting dyes. We conclude that direct interaction between the analyte and the semiconducting material is generally more sensitive and cost effective, despite being currently limited by the need to identify, and synthesize selective sensing functionalities. It is also worth noting the potential roles of highly-sensitive, organic transistor devices and small molecule semiconductors, such as the photochromic and redox active molecule spiropyran, as polymer pendant groups in future biosensor designs.

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“…A family of enzymes with a well-recognized ability for the detection of substances including pharmaceuticals are oxidases and peroxidases [58,59]. They have been reported to work either independently or in combination.…”

Section: Oxidase/peroxidase Based-biosensorsmentioning

confidence: 99%

“…Oxidase/Peroxidase based-biosensors have been successfully used to detect molecules such as glucose, alcohol, putrescine, oxygen, hydrogen peroxide and other small metabolites. This has been useful for applications in the food industry, medical diagnosis and in vitro assays of pharmaceutical trials [21,59,63,64,65]. Even though these enzymatic biosensors exhibit high sensitivity and selectivity toward the detection of small molecules, their use is limited due to issues regarding low stability of the enzyme molecules during the fabrication, special storage conditions, and complicated implementation protocols [63].…”

Section: Oxidase/peroxidase Based-biosensorsmentioning

confidence: 99%

Enzyme-Based Electrochemical Biosensors for Microfluidic Platforms to Detect Pharmaceutical Residues in Wastewater

et al. 2019

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Emerging water pollutants such as pharmaceutical contaminants are suspected to induce adverse effects to human health. These molecules became worrisome due to their increasingly high concentrations in surface waters. Despite this alarming situation, available data about actual concentrations in the environment is rather scarce, as it is not commonly monitored or regulated. This is aggravated even further by the absence of portable and reliable methods for their determination in the field. A promising way to tackle these issues is the use of enzyme-based and miniaturized biosensors for their electrochemical detection. Here, we present an overview of the latest developments in amperometric microfluidic biosensors that include, modeling and multiphysics simulation, design, manufacture, testing, and operation methods. Different types of biosensors are described, highlighting those based on oxidases/peroxidases and the integration with microfluidic platforms. Finally, issues regarding the stability of the biosensors and the enzyme molecules are discussed, as well as the most relevant approaches to address these obstacles.

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A multipurpose conjugated polymer: Electrochromic device and biosensor construction for glucose detection

Cited by 44 publications

References 34 publications

Recent Advances in In Vivo Neurochemical Monitoring

Recent Advances in In Vivo Neurochemical Monitoring

All-Organic Semiconductors for Electrochemical Biosensors: An Overview of Recent Progress in Material Design

Enzyme-Based Electrochemical Biosensors for Microfluidic Platforms to Detect Pharmaceutical Residues in Wastewater

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