A multiscale model for multiple platelet aggregation in shear flow

Decoding thrombosis through code: a review of computational models

“…These models include individual platelet responses to the mechanical (shear rates) and biochemical environment (agonist concentration). These models capture platelet interactions in more detail by combining receptorligand binding with hemodynamic calculations to predict individual platelet motion and adhesion, eg, tumbling and sliding along a substrate [ 18 , 53 , 54 ]. Simulations using this approach demonstrate that platelet shape leads to fundamentally different collision behavior with a surface compared with a sphere [ 53 , 54 ].…”

“…As demonstrated, biomechanical characteristics of platelets are best studied with these mesoscale models. Platelet aggregation models can also test how plasma proteins interact with individual platelets, eg, potentiating platelet aggregation through von Willebrand factor extension and entanglement in high shear flow [ 55 ] ( Figure 4D ), or testing fibrinogen-based binding at low shear based on interplatelet contact area and platelet deformability [ 17 , 18 ]. These models also have the potential to predict patient-specific bleeding and platelet aggregation [ 56 ].…”

“…At the subcellular scale, platelet deformation models [ 15 – 18 ] offer an opportunity to capture microstructural changes (eg, actin polymerization) as platelets undergo shape change during activation. The membrane, cytoskeleton, and cytoplasm can be included in these models to simulate general platelet structure to quantify the stress distribution along a platelet membrane during collisions and while transporting in shear flow [ 19 ].…”

Dialysis flow rate in central venous catheters – A numerical analisys with experimental validation.

“…7, that the recirculation zones and the flow field disturbances are more significant in regions and instants of time of lower velocity and shear stress along the cardiac cycle. Studies has shown that platelet aggregation tends to occur in regions of low shear stress, and recirculation zone, which may be associated to higher blood particles exposure time [33][34][35][36][37].…”

“…Figure 7 also shows the average shear stress along the streamline (𝜏) for the different instants of time.It can be seen, in Fig.7, that the recirculation zones and the flow field disturbances are more significant in regions and instants of time of lower velocity and shear stress along the cardiac cycle. Studies has shown that platelet aggregation tends to occur in regions of low shear stress, and recirculation zone, which may be associated to higher blood particles exposure time[33][34][35][36][37].The permanence time of blood particles in the layers closed to the wall is an important factor for the beginning of platelet adhesion and the consequent formation of fibrin and thrombus[33,38,39]. Thus, in areas of disturbance and separation of the flow field, platelets may be exposed to alternating peaks of increase and decrease in acceleration and shear stress.…”