A Nanoparticle Size Series for In Vivo Fluorescence Imaging

Popović, Zoran V.; Liu, Wenhao; Chauhan, Vikash P.; Lee, Jungmin; Wong, Cliff; Greytak, Andrew B.; Insin, Numpon; Nocera, Daniel G.; Fukumura, Dai; Jain, Rakesh K.; Bawendi, Moungi G.

doi:10.1002/ange.201003142

Cited by 111 publications

(120 citation statements)

References 23 publications

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“…Commonly used polymers, such as polystyrene and poly(methylmethacrylate) [ 27 ] are relatively less stable and tight in comparison to their inorganic counterparts. Inorganic matrices on the other hand can incorporate the QDs directly from their melt, e.g., using the Czochralski approach, [ 28 ] coated as a thin fi lm directly on their surface [ 29,30 ] or, as recently developed by our group, grown as mixed crystals at ambient temperatures from a saturated salt solution. [ 31 ] Using this method, different types of QDs can be incorporated due to the low thermal stress and, by choosing the proper matrix-QD system, the photoluminescence quantum yields (PL-QYs) are enhanced upon incorporation.…”

mentioning

confidence: 99%

Liquid–Liquid Diffusion‐Assisted Crystallization: A Fast and Versatile Approach Toward High Quality Mixed Quantum Dot‐Salt Crystals

Adam

Wang

Dubavik

et al. 2015

Adv Funct Materials

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2638www.MaterialsViews.com wileyonlinelibrary.com approaches, [ 15,16 ] effi ciency, [ 17,18 ] extending their spectral range [19][20][21] and environmental friendliness using less toxic materials [22][23][24] sparked industrial applications. Those started with the demonstration of a 40 in. display prototype presented by Samsung [ 25 ] and followed by the foundation of QD Vision, Inc., [ 26 ] whose QDs are now used in the latest series of Sony products. All of the mentioned applications require long-term stability of the QDs under various conditions including high temperatures as well as high intensity illumination. Packaging of the QDs within polymer or inorganic matrices is one way to address these issues, while improving the processability of the QDs at the same time. Commonly used polymers, such as polystyrene and poly(methylmethacrylate) [ 27 ] are relatively less stable and tight in comparison to their inorganic counterparts. Inorganic matrices on the other hand can incorporate the QDs directly from their melt, e.g., using the Czochralski approach, [ 28 ] coated as a thin fi lm directly on their surface [ 29,30 ] or, as recently developed by our group, grown as mixed crystals at ambient temperatures from a saturated salt solution. [ 31 ] Using this method, different types of QDs can be incorporated due to the low thermal stress and, by choosing the proper matrix-QD system, the photoluminescence quantum yields (PL-QYs) are enhanced upon incorporation. [ 32,33 ] Here, a new, fast, and versatile method for the incorporation of colloidal quantum dots (QDs) into ionic matrices enabled by liquid-liquid diffusion is demonstrated. QDs bear a huge potential for numerous applications thanks to their unique chemical and physical properties. However, stability and processability are essential for their successful use in these applications. Incorporating QDs into a tight and chemically robust ionic matrix is one possible approach to increase both their stability and processability. With the proposed liquid-liquid diffusion-assisted crystallization (LLDC), substantially accelerated ionic crystallization of the QDs is shown, reducing the crystallization time needed by one order of magnitude. This fast process allows to incorporate even the less stable colloids including initially oil-based ligandexchanged QDs into salt matrices. Furthermore, in a modifi ed two-step approach, the seed-mediated LLDC provides the ability to incorporate oilbased QDs directly into ionic matrices without a prior phase transfer. Finally, making use of their processability, a proof-of-concept white light emitting diode with LLDC-based mixed QD-salt fi lms as an excellent color-conversion layer is demonstrated. These fi ndings suggest that the LLDC offers a robust, adaptable, and rapid technique for obtaining high quality QD-salts.

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mentioning

confidence: 99%

Liquid–Liquid Diffusion‐Assisted Crystallization: A Fast and Versatile Approach Toward High Quality Mixed Quantum Dot‐Salt Crystals

Adam

Wang

Dubavik

et al. 2015

Adv Funct Materials

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“…[468] Such nanoparticles appear to have the highest internalization and modest exocytosis rates, [469] while nanoparticles with hydrodynamic sizes larger than 60 nm are poorly taken up by tumor cells. [470] In a recent study, Salva et al have also reported that manganese oxide nanoparticle with an average [461] Copyright 2015, Elsevier. b) Adapted with permission.…”

Section: Passive Targetingmentioning

confidence: 98%

Synthesis, Functionalization, and Design of Magnetic Nanoparticles for Theranostic Applications

Mosayebi

Kiyasatfar

Laurent

2017

Adv Healthcare Materials

204

171

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In order to translate nanotechnology into medical practice, magnetic nanoparticles (MNPs) have been presented as a class of non‐invasive nanomaterials for numerous biomedical applications. In particular, MNPs have opened a door for simultaneous diagnosis and brisk treatment of diseases in the form of theranostic agents. This review highlights the recent advances in preparation and utilization of MNPs from the synthesis and functionalization steps to the final design consideration in evading the body immune system for therapeutic and diagnostic applications with addressing the most recent examples of the literature in each section. This study provides a conceptual framework of a wide range of synthetic routes classified mainly as wet chemistry, state‐of‐the‐art microfluidic reactors, and biogenic routes, along with the most popular coating materials to stabilize resultant MNPs. Additionally, key aspects of prolonging the half‐life of MNPs via overcoming the sequential biological barriers are covered through unraveling the biophysical interactions at the bio–nano interface and giving a set of criteria to efficiently modulate MNPs' physicochemical properties. Furthermore, concepts of passive and active targeting for successful cell internalization, by respectively exploiting the unique properties of cancers and novel targeting ligands are described in detail. Finally, this study extensively covers the recent developments in magnetic drug targeting and hyperthermia as therapeutic applications of MNPs. In addition, multi‐modal imaging via fusion of magnetic resonance imaging, and also innovative magnetic particle imaging with other imaging techniques for early diagnosis of diseases are extensively provided.

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“…526 In another example, Popovic and colleagues reported the use of QDs coated with a silica shell of varying thickness to probe the role of nanoparticle size in determining tumor tissue accumulation for cancer diagnostic applications. 382 By varying the composition of the QD cores, the researchers found that each of the resulting nanoparticles, with diameters ranging from 12 to 120 nm, exhibited distinct emission colors. A mixture of 12, 60, and 120 nm silica-coated QDs was injected intravenously into a xenografted Mu89 human melanoma mouse model.…”

Section: Detection Of Tumor Tissue In Vivomentioning

confidence: 99%

Nanoparticle Probes for the Detection of Cancer Biomarkers, Cells, and Tissues by Fluorescence

et al. 2015

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A Nanoparticle Size Series for In Vivo Fluorescence Imaging

Cited by 111 publications

References 23 publications

Liquid–Liquid Diffusion‐Assisted Crystallization: A Fast and Versatile Approach Toward High Quality Mixed Quantum Dot‐Salt Crystals

Liquid–Liquid Diffusion‐Assisted Crystallization: A Fast and Versatile Approach Toward High Quality Mixed Quantum Dot‐Salt Crystals

Synthesis, Functionalization, and Design of Magnetic Nanoparticles for Theranostic Applications

Nanoparticle Probes for the Detection of Cancer Biomarkers, Cells, and Tissues by Fluorescence

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