Nanoparticle Probes for the Detection of Cancer Biomarkers, Cells, and Tissues by Fluorescence

Chinen, Alyssa B.; Guan, Chenxia M.; Ferrer, Jennifer R.; Barnaby, Stacey N.; Merkel, Timothy J.; Mirkin, Chad A.

doi:10.1021/acs.chemrev.5b00321

Cited by 930 publications

(593 citation statements)

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“…have been used as efficient fluorescent labels. 9 Many generalized reviews have appeared showing remarkable optical properties of graphene and its derivatives over other nanomaterials. [111][112][113][114][115][116] Pristine graphene has a zero intrinsic band gap thereby limiting its use in many optical applications that are based on photo-excited PL.…”

Section: Graphene Based Optical Biosensing Systemmentioning

confidence: 99%

“…6,7 Among these nanomaterials, metallic nanomaterials, silica nanoparticles (NPs), dendrimers, quantum dots (QDs), polymer NPs, carbon nanotubes (CNTs), nanodiamonds (NDs), and 2D-nanomaterials [graphene, hexagonalboron nitride (h-BN), transition metal dichalcogenides (TMDs) such as niobium selenide (NbSe 2 ), molybdenum disulfide (MoS 2 ), and tungsten disulfide (WS 2 )] are highly studied and have significantly contribution to biosensor development. [8][9][10][11][12] In particular, graphene is the most promising nanostructured carbon material that is used in the bioanalytical area and has stimulated intense research as it possesses an excellent combination of enhanced specific surface area, electrical conductivity, chemical stability, ease of manipulation and biocompatibility, thus, providing more specific sites to capture foreign moieties with high sensitivity. In addition, it is resistant to the harsh ionic solutions found in body.…”

Section: Introductionmentioning

confidence: 99%

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Graphene based biosensors—Accelerating medical diagnostics to new-dimensions

2017

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Graphene has emerged as a champion material for a variety of applications cutting across multiple disciplines in science and engineering. Graphene and its derivatives have displayed huge potential as a biosensing material due to their unique physicochemical properties, good electrical conductivity, optical properties, biocompatibility, ease of functionalization, and flexibility. Their widespread use in making biosensors has opened up new possibilities for early diagnosis of life-threatening diseases and real-time health monitoring. Following an introduction and discussion on the significance of fabrication protocols and assembly, this review is intended to assess why graphene is suitable to build better biosensors, the working of existing biosensing schemes and their current status toward commercialization for wearable diagnostic and prognostic devices. We believe this review will provide a critical insight for harnessing graphene as a suitable biosensor for the clinical diagnostics, its future prospects and challenges ahead.

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Section: Graphene Based Optical Biosensing Systemmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Graphene based biosensors—Accelerating medical diagnostics to new-dimensions

2017

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“…However, existing approaches for evaluating the nanoformulated drugs are mainly based on traditional medication. As to nanoformulated drug screening, additional challenges arise from the special physicochemical properties of nanoparticles 3, 4, 5. Nanoparticles might distort the most of in vitro classical cytotoxicity assay including 3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium bromide (MTT) and lactate dehydrogenase release assays.…”

Section: Introductionmentioning

confidence: 99%

DeepScreen: An Accurate, Rapid, and Anti‐Interference Screening Approach for Nanoformulated Medication by Deep Learning

et al. 2018

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Accuracy of current efficacy judgment methods for nanoformulated drug remains unstable due to the interference of nanocarriers. Herein, DeepScreen, a drug screening system utilizing convolutional neural network based on flow cytomerty single‐cell images, is introduced. Compared to existing experimental approaches, the high‐throughput system has superior precision, rapidity, and anti‐interference, and is cost‐cutting with high accuracy. First, it can resist most disturbances from manual factors of complicated evaluation progress. In addition, class activation maps generated from DeepScreen indicate that it may identify and locate the tiny variation from cell apoptosis and slight changes of cellular period caused by drug or even nanoformulated drug action at very early stages. More importantly, the excellent performance of assessment on two types of nanoformulations and fluorescent drug proves the fine generality and anti‐interference of this novel system. All these privileged performances make DeepScreen a very smart and promising system for drug detection.

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“…[1][2][3][4] Compared with other nanoparticles, AuNPs have been extensively used due to the progress in chemical methods to control their morphology, which results in the tunability of their optical and thermal properties. [5][6][7][8][9] In particular, gold nanospheres (AuNSs) are broadly utilized in applications due to their fast and facile synthesis, low cytotoxicity and ease of bioconjugation.…”

Section: Introductionmentioning

confidence: 99%

Investigating the stability of DNA-coated gold nanoparticles

Kyriazi

Kanaras

2018

Colloidal Nanoparticles for Biomedical Applications XIII

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In this paper we investigate how the density of oligonucleotides around spherical 15 nm gold nanoparticles (AuNPs) influences their stability against degradation by DNase I. We show that a significant decrease in the number of oligonucleotides attached to the AuNP surface is directly correlated with an increase in the DNA degradation by DNase I. Our experimental observations suggest that a close packing of oligonucleotides into a 3d arrangement at the surface of AuNPs endows the probes with the necessary stability required for their use in intracellular applications.

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Nanoparticle Probes for the Detection of Cancer Biomarkers, Cells, and Tissues by Fluorescence

Abstract: Graphical Abstract

Cited by 930 publications

References 577 publications

Graphene based biosensors—Accelerating medical diagnostics to new-dimensions

Graphene based biosensors—Accelerating medical diagnostics to new-dimensions

DeepScreen: An Accurate, Rapid, and Anti‐Interference Screening Approach for Nanoformulated Medication by Deep Learning

Investigating the stability of DNA-coated gold nanoparticles

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