A nanoscale drug-entrapment strategy for hydrogel-based systems for the delivery of poorly soluble drugs

Effects of Azithromycin in Combination with Vancomycin, Daptomycin, Fosfomycin, Tigecycline, and Ceftriaxone on Staphylococcus epidermidis Biofilms

“…Bonding azithromycin to polymer-coated prosthetic surfaces may deliver high local concentrations that may not only prevent colonization and adherence but also-together with the systemically administered antimicrobial substances with excellent tissue penetration and little protein binding-reduce biofilms. This is, so far, a hypothesis only, but new materials and techniques, including nanotechnology, are being developed rapidly (6). Additionally, in the present study, biofilms were treated for 24 h only, and antimicrobial treatment of implant infections is usually administered for a longer period.…”

Restenosis Treatments Using Nanoparticle-based Drug Delivery Systems

“…Chen et al developed a hydrogel-based device in which rapamycin was entrapped in the core of self-assembled Pluronic co-polymer micelles [44] (Fig. 2A).…”

Multifunctional Polymeric Nanostructures for Therapy and Diagnosis

“…Hydrogels have been developed as stimuli-responsive materials, which can undergo abrupt volume change in response to small changes in environmental parameters, such as temperature, pH, ionic strength, etc. These unique characteristics of hydrogels are of great interest in drug delivery, cell encapsulation and tissue engineering [176][177]. Stimuli-responsive polymers play an important role in the development of novel smart hydrogels [178][179][180][181][182][183].…”