A nanoscale probe for fluidic and ionic transport

Bourlon, B.; Wong, Joyce Y.; Mikó, C.; Forró, Lászlø; Bockrath, Marc

doi:10.1038/nnano.2006.211

Cited by 77 publications

(91 citation statements)

References 28 publications

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“…[1] This can be traced, in part, to the need for reliable information on physical and/or chemical events occurring in reaction volumes that are extremely difficult to access by conventional imaging technology. In specific cases, the capability to construct miniaturised tools (e.g., nano-electrodes) [2] has opened up new means by which to monitor in situ growth of insoluble residues, [3] corrosion, [4] leakage [5] and flow dynamics, [6] for example. Although we seem certain to witness a great expansion in such technology, the accompanying problem of being able to access ever-smaller dimensions must not be overlooked.…”

Section: Introductionmentioning

confidence: 99%

Redox‐Controlled Fluorescence Modulation in a BODIPY‐Quinone Dyad

et al. 2008

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The synthesis and properties of two closely related boron dipyrromethene (BODIPY) derived dyads, incorporating redoxactive quinone units appended at the meso position, are described. For one dyad, the quinone unit is attached directly to the BODIPY core, whereas a phenylene spacer separates the two units in the second compound. Each of the quinone units is readily converted, by both chemical and electrochemical means, to the corresponding hydroquinone derivative. The strong fluorescence normally associated with the BODIPY unit is efficiently quenched in both dyads in their quinone forms. This is attributed to deactivation of the first excited singlet state by a way of an intramolecular electron-

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Section: Introductionmentioning

confidence: 99%

Redox‐Controlled Fluorescence Modulation in a BODIPY‐Quinone Dyad

et al. 2008

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“…Carbon nanotubes, conversely, have outstanding potential for applications such as nanoscale sensors, devices, and nanomachines (5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20). Meanwhile, water molecules confined within nanoscale channels exhibit structures and dynamics that are very different from bulk (7)(8)(9)(10)(11)(12)(21)(22)(23)(24)(25)(26)(27), which might provide a medium for molecular signal transmission.…”

mentioning

confidence: 99%

Water-mediated signal multiplication with Y-shaped carbon nanotubes

Xiu

Wan

et al. 2009

Proc. Natl. Acad. Sci. U.S.A.

123

110

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Molecular scale signal conversion and multiplication is of particular importance in many physical and biological applications, such as molecular switches, nano-gates, biosensors, and various neural systems. Unfortunately, little is currently known regarding the signal processing at the molecular level, partly due to the significant noises arising from the thermal fluctuations and interferences between branch signals. Here, we use molecular dynamics simulations to show that a signal at the single-electron level can be converted and multiplied into 2 or more signals by water chains confined in a narrow Y-shaped nanochannel. This remarkable transduction capability of molecular signal by Y-shaped nanochannel is found to be attributable to the surprisingly strong dipoleinduced ordering of such water chains, such that the concerted water orientations in the 2 branches of the Y-shaped nanotubes can be modulated by the water orientation in the main channel. The response to the switching of the charge signal is very rapid, from a few nanoseconds to a few hundred nanoseconds. Furthermore, simulations with various water models, including TIP3P, TIP4P, and SPC/E, show that the transduction capability of the Y-shaped carbon nanotubes is very robust at room temperature, with the interference between branch signals negligible.confined water ͉ molecular dynamics ͉ molecular signal transmission ͉ Y-shaped nanochannel ͉ signal transduction

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“…For example, high flow rates are known to change the electrostatic potential at the sensor surface, thereby interfering with the sensing of charged proteins. 18 The pH sensing experiment gives a lower limit of the lag-time for proteins to begin binding to a biosensor. Protons diffuse rapidly across flow lines and will reach the sensor surface faster than proteins.…”

Section: Sensor Response Time and Calibrationmentioning

confidence: 99%

Fabrication and characterization of carbon nanotube field-effect transistor biosensors

et al. 2010

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We report the fabrication of carbon nanotube field-effect transistors for biosensing applications and the development of protocols for reliable protein and DNA sensing. The sensing method we employ is 'label free', relying only on the intrinsic charge of the biological molecule of interest. We discuss fabrication issues that we have solved, for example the preparation of clean surfaces, and the sensing protocol issues that we have encountered. Polylysine and ss-dna, highly charged biological molecules, are used as model systems to illustrate the performance of our biosensors.

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A nanoscale probe for fluidic and ionic transport

Cited by 77 publications

References 28 publications

Redox‐Controlled Fluorescence Modulation in a BODIPY‐Quinone Dyad

Redox‐Controlled Fluorescence Modulation in a BODIPY‐Quinone Dyad

Water-mediated signal multiplication with Y-shaped carbon nanotubes

Fabrication and characterization of carbon nanotube field-effect transistor biosensors

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