A nanosensor for in vivo selenol imaging based on the formation of Au Se bonds

Colloidal and Deposited Products of the Interaction of Tetrachloroauric Acid with Hydrogen Selenide and Hydrogen Sulfide in Aqueous Solutions

“…The assignment of the Au 4f components is not straightforward, particularly, since AuSe contains two sorts of Au atoms, the oxidation state of which is a matter of dispute [35][36][37][38][39][40][41][42][43][44][45]. The Au 4f 7/2 peaks at 84.0-84.4 eV reported for gold-gold selenide [39][40][41], gold-CdSe [44,45]), adlayers of Se or alkyl selenides at Au [45][46][47][48][49]59], etc., originate from Au 0 surfaces but not AuSe phases. In nanostructured AuSe with admixture of Au [42], the values of 83.7 eV and 84.9 eV have been found, along with Se 3d 5/2 line at 54.5 eV, and ascribed to Au 0 and Au + , respectively; nevertheless, the authors assert the mixed valence state of gold (Au + Au 3+ Se 2 ).…”

“…It is known from chemistry textbooks (for example [38]) that direct interaction between aqueous gold complexes and selenide ions results in precipitation of unstable gold selenides with unclear compositions. Preparation of nanoscale materials containing gold selenide have been described in a few publications [17,[39][40][41][42][43][44][45]. Nath and co-workers [39] have synthesized "AuSe nanoalloys" via fusion of elemental Au and Se nanoparticles in a micellar solution, typically with an excess of Au NPs.…”

Fluorescent Probes Containing Selenium as a Guest or Host

“…Recently, Hu et al 33 reported the results of studies of an NIR fluorescent nanosensor for detecting selenols. The key design feature of this nanosensor is that the stability of the Au-Se bond is higher than that of the analogous Au-S bond, and the details of this strategy are illustrated in Figure 2.…”

“…Schematic Illustration of the Nanosensor for Detection of Selenol in Cancer Cells Induced by Na 2 SeO 3 under Hypoxic ConditionsReprinted with permission from Hu el al 33. Copyright 2016 Elsevier Inc.…”

Double-ratiometric fluorescence imaging of H2Se and O2˙− under hypoxia for exploring Na2SeO3-induced HepG2 cells' apoptosis

“…[9][10][11][12] Specically, hydrogen selenide (H 2 Se) is the key small molecule metabolite of Na 2 SeO 3 in vivo, and it reacts with O 2 to produce and accumulate a large amount of ROS (mainly the superoxide anion, O 2 c À ), resulting in tumor cell oxidative stress, which leads to apoptosis. [13][14][15][16] Nevertheless, since the tumor microenvironment is hypoxic (0.7-1.8% O 2 ) 17 due to the rapid proliferation of cancer cells and imbalance of new blood vessel formation, [18][19][20] it is still a great challenge to understand the anti-cancer mechanism in hypoxic conditions, which needs to be solved urgently.…”