A Nanozyme with Photo‐Enhanced Dual Enzyme‐Like Activities for Deep Pancreatic Cancer Therapy

Abstract

Nanozymes have attracted extensive interest owing to their high stability, low cost and easy preparation, especially in the field of cancer therapy. However, the relatively low catalytic activity of nanozymes in the tumor microenvironment (TME) has limited their applications. Herein, we report a novel nanozyme (PtFe@Fe3O4) with dual enzyme‐like activities for highly efficient tumor catalytic therapy. PtFe@Fe3O4 shows the intrinsic photothermal effect as well as photo‐enhanced peroxidase‐like and catalase‐like activities in the acidic TME, thereby effectively killing tumor cells and overcoming the tumor hypoxia. Importantly, a possible photo‐enhanced synergistic catalytic mechanism of PtFe@Fe3O4 was first disclosed. We believe that this work will advance the development of nanozymes in tumor catalytic therapy.

Porous CuxCoyS Supraparticles for In Vivo Telomerase Imaging and Reactive Oxygen Species Generation

“…Cancer cells and tumors are associated with a very specific microenvironment and characteristic expression levels. For example, the tumor microenvironment is often associated with high expression levels of telomerase, microRNA, and epidermal growth factor, and often features low pH values, high H 2 O 2 level, and low oxygen levels (hypoxia . Based on these special characteristics, a number of nanoassemblies have been developed for the intracellular imaging of significant biomarkers related to specific features of the tumor microenvironment.…”

Nanozymes: a new choice for disease treatment

“…因此, 在杀菌的同 时破坏生物膜或抑制生物膜的再生是促进伤口愈合和 抗伤口感染的重要策略. Yan和Liu课题组 [56] 合成了一 图 7 AMP NRs介导热疗的作用机理 [45] (网络版彩图) Figure 7 Schematic illustration of AMP NRs mediated PTT [45] (color online) (网络版彩图) Figure 8 Design and antibacterial mechanism of the 2D MOF/GOx hybrid nanocatalyst as a benign and self-activated cascade reagenta [52] (color online) 图 9 MoS 2 纳米水凝胶的合成过程及其在抗菌和促进伤口 愈合中的作用机理 [58] (网络版彩图) Figure 9 Synthesis of MoS 2 nanohydrogel and its mechanism in antibacterial and wound healing [58] (color online) [61] (网络版彩图) Figure 10 Mechanisms of dextran-coated iron oxide nanoparticles in the treatment of dental caries [61] (color online) 以MOF-AuNPs纳米杂 化物为放射增敏平台, 并在其内包载阿霉素, 实现了放 图 11 基于PtFe@Fe 3 O 4 纳米酶的光增强肿瘤催化治疗原 理 [66] (网络版彩图) Figure 11 Schematic of the photo-enhanced tumor catalytic therapy based on the PtFe@Fe 3 O 4 nanozyme [66] (color online)…”

Progress and Trend on the Regulation Methods for Nanozyme Activity and Its Application

“…These above stimuli factors can be applied for improving the diagnostic and therapeutic efficacies of different diseases in biomedical applications. For example, Li et al developed a PtFe@Fe 3 O 4 nanozyme with two kinds of enzyme-like catalytical activities for tumor therapy [99]. In the tumor microenvironment, the PtFe@Fe 3 O 4 nanozymes exhibited a photothermal effect with photo-enhanced catalase-like and peroxidase-like activities.…”