A naturalistic longitudinal study of at-risk mental state with a 2.4 year follow-up at a specialized clinic setting in Japan

Katsura, Masahiro; Ohmuro, Noriyuki; Obara, Chika; Kikuchi, Tatsuo; Ito, Fumiaki; Miyakoshi, Tetsuo; Matsuoka, Hiroo; Matsumoto, Kazunori

doi:10.1016/j.schres.2014.06.013

Cited by 43 publications

(52 citation statements)

References 41 publications

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“…This rate is now considered as typical of prodromal research in general (Niendam et al, 2013;Yaakub et al, 2013;Katsura et al, 2014) and similar to the conversion rates in various consortia, such as the European Prediction of Psychosis Study (Salokangas et al, 2012). These rates reflect a decline in conversion since the time of the original reports in CHR samples (Yung et al, 2007).…”

Section: Neural Dysfunction In Cognitive Control Circuits T Colibazzisupporting

confidence: 65%

Neural Dysfunction in Cognitive Control Circuits in Persons at Clinical High-Risk for Psychosis

Colibazzi

Horga

Wang

et al. 2015

Neuropsychopharmacol

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Cognitive control, a set of functions that develop throughout adolescence, is important in the pathogenesis of psychotic disorders. Whether cognitive control has a role in conferring vulnerability for the development of psychotic illness is still unknown. The aim of this study was to investigate the neural systems supporting cognitive control in individuals deemed to be potentially prodromal for psychotic illness. We recruited 56 participants at clinical high-risk (CHR) for psychosis based on the Structured Interview for Psychosis-Risk Syndromes (SIPS) and 49 healthy controls. Twelve of the CHR participants eventually developed psychosis. We compared functional magnetic resonance imaging (fMRI) BOLD signal during the performance of the Simon task. We tested for differences between CHR individuals and controls in conflict-related functional activity. In the CHR group when compared with controls, we detected smaller conflictrelated activations in several cortical areas, including the Dorsolateral Prefrontal Cortex (DLPFC). Furthermore, conflict-related activations in the DLPFC of those CHR individuals who ultimately developed psychosis (CHR converters) were smaller than in non-converters (CHR non-converters). Higher levels of conflict-related activation were associated with better social and role outcome. Risk for psychosis was associated at the neural level with reduced conflict-related brain activity. This neural phenotype appears correlated within the DLPFC with the development of psychosis and with functional outcome.

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Section: Neural Dysfunction In Cognitive Control Circuits T Colibazzisupporting

confidence: 65%

Neural Dysfunction in Cognitive Control Circuits in Persons at Clinical High-Risk for Psychosis

Colibazzi

Horga

Wang

et al. 2015

Neuropsychopharmacol

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“…Supplementary [40,59,60,112,113,132,133]. Baseline CHR sample sizes ranged from seven [60] to 817 [77] including altogether 4952 CHR subjects.…”

Section: Included Studies and Study Designmentioning

confidence: 99%

EPA guidance on the early detection of clinical high risk states of psychoses

et al. 2015

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The aim of this guidance paper of the European Psychiatric Association is to provide evidence-based recommendations on the early detection of a clinical high risk (CHR) for psychosis in patients with mental problems. To this aim, we conducted a meta-analysis of studies reporting on conversion rates to psychosis in non-overlapping samples meeting any at least any one of the main CHR criteria: ultra-high risk (UHR) and/or basic symptoms criteria. Further, effects of potential moderators (different UHR criteria definitions, single UHR criteria and age) on conversion rates were examined. Conversion rates in the identified 42 samples with altogether more than 4000 CHR patients who had mainly been identified by UHR criteria and/or the basic symptom criterion 'cognitive disturbances' (COGDIS) showed considerable heterogeneity. While UHR criteria and COGDIS were related to similar conversion rates until 2-year follow-up, conversion rates of COGDIS were significantly higher thereafter. Differences in onset and frequency requirements of symptomatic UHR criteria or in their different consideration of functional decline, substance use and co-morbidity did not seem to impact on conversion rates. The 'genetic risk and functional decline' UHR criterion was rarely met and only showed an insignificant pooled sample effect. However, age significantly affected UHR conversion rates with lower rates in children and adolescents. Although more research into potential sources of heterogeneity in conversion rates is needed to facilitate improvement of CHR criteria, six evidence-based recommendations for an early detection of psychosis were developed as a basis for the EPA guidance on early intervention in CHR states.

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“…Recently, 'disorganized speech' was the only positive item distinguishing converters (13.2%, mainly within 1 year) from non-converters in a 14-35-year-old UHR sample with a 2.4-year-followup (Katsura et al, 2014). Furthermore, 'disorganized communication' was the sole predictor of psychosis in a UHR sample (12-30-year-olds) with a 26% conversion rate at 2.5-year follow-up, and suggested as a potential endophenotype or stable trait marker for schizophrenia risk (DeVylder et al, 2014).…”

Section: Conversion To Psychosis At One-year Follow-upmentioning

confidence: 99%

Twelve-month psychosis-predictive value of the ultra-high risk criteria in children and adolescents

Armando

Pontillo

Crescenzo

et al. 2015

Schizophrenia Research

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Objective: The validity of current ultra-high risk (UHR) criteria is under-examined in help-seeking minors, particularly, in children below the age of 12 years. Thus, the present study investigated predictors of one-year outcome in children and adolescents (CAD) with UHR status.Method: Thirty-five children and adolescents (age 9-17 years) meeting UHR criteria according to the Structured Interview for Psychosis-Risk Syndromes were followed-up for 12 months.Regression analyses were employed to detect baseline predictors of conversion to psychosis and of outcome of non-converters (remission and persistence of UHR versus conversion).

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A naturalistic longitudinal study of at-risk mental state with a 2.4 year follow-up at a specialized clinic setting in Japan

Cited by 43 publications

References 41 publications

Neural Dysfunction in Cognitive Control Circuits in Persons at Clinical High-Risk for Psychosis

Neural Dysfunction in Cognitive Control Circuits in Persons at Clinical High-Risk for Psychosis

EPA guidance on the early detection of clinical high risk states of psychoses

Twelve-month psychosis-predictive value of the ultra-high risk criteria in children and adolescents

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