A near-infrared fluorescent probe for evaluating endogenous hydrogen peroxide during ischemia/reperfusion injury

Xu, Runfeng; Wang, Yue; Huh, You; Zhang, Liangwei; Wang, Yunqing; Chen, Lingxin

doi:10.1039/c9an00243j

Cited by 27 publications

(7 citation statements)

References 56 publications

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“…Reactive oxygen species (ROS), inducing extensive degradation of the extracellular matrix of cartilage and extracellular toxicity to intra-articular tissues via DNA damage and modifying the lipid, , plays an essential role in the onset and progression of OA. , Thus, clearing the high levels of intracellular ROS may further reinforce therapeutic efficacy in OA . In recent years, ROS-responsive nanoparticles have been extensively studied and applied with the swift development of biomedical materials, − and plenty of nanocarriers have presented the adequate advantage of ROS responsiveness and ROS consumption. − For instance, Tang et al used a combination of living anionic ring-opening polymerization of poly(propylene sulfide) and atom transfer of the radical to prepare polymeric micelles, which efficiently responded to the intracellular ROS and simultaneously released the drugs. In the treatment of OA, ROS-responsive polymeric micelles can both encapsulate hydrophobic drugs (i.e., KGN and Dex) in the core to achieve an ROS-responsive release behavior and decrease the levels of ROS.…”

Section: Introductionmentioning

confidence: 99%

Nanoarchitectonics of Cartilage-Targeting Hydrogel Microspheres with Reactive Oxygen Species Responsiveness for the Repair of Osteoarthritis

Huang

Kong

et al. 2022

ACS Appl. Mater. Interfaces

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Clinically, intra-articular administration can hardly achieve the truly targeted therapy, and the drugs are usually insufficient to show local and long-term therapeutic effects because of their rapid clearance. Herein, inspired by the phenomenon that bees track the scent of flowers to collect nectar, we developed cartilage-targeting hydrogel microspheres with reactive oxygen species (ROS)-responsive ability via combining the microfluidic method and photopolymerization processes to integrate cartilagetargeting peptides and ROS-responsive nanoparticles in the hydrogel matrix. The hydrogel microspheres with cartilage-targeting properties promoted better retention in the joint cavity and enhanced cellular uptake of the nanoparticles. Moreover, the ROSresponsive nanoparticles could react with osteoarthritis (OA)-induced intracellular ROS, resulting in the depolymerization of nanoparticles, which could not only eliminate excess ROS and reduce inflammation but also promote the release of dexamethasone (Dex) and kartogenin (KGN) in situ, realizing effective OA therapy. It was demonstrated that this hydrogel microsphere showed favorable ROS-responsive ability and enhanced chondrogenic differentiation as well as the downregulation of pro-inflammatory factors in vitro. Additionally, the hydrogel microspheres, similar to bees, could target and effectively repair cartilage in the OA model. Thus, the injectable hydrogel microspheres exerted an excellent potential to repair OA and may also provide an effective avenue for inflammatory bowel disease therapy.

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Section: Introductionmentioning

confidence: 99%

Nanoarchitectonics of Cartilage-Targeting Hydrogel Microspheres with Reactive Oxygen Species Responsiveness for the Repair of Osteoarthritis

Huang

Kong

et al. 2022

ACS Appl. Mater. Interfaces

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“…Real-time detection of changes in O 2 *À levels may be beneficial for medical diagnosis. Finally, this study showed that cyanine 73 can be used to pre-evaluate clinical surgeries.Inspired by the changes in endogenous superoxide anions during I/R injuries, [96] Xu et al [97] synthesized heptamethine cyanine dye 75 to evaluate the relationship between H 2 O 2 , a downstream product of the superoxide, and organ damage during liver I/R. This cyanine was designed by uniting two different parts: a heptamethine cyanine dye (NIR fluorophore) and a boronate ester group (response unit) (Figure 16a).…”

Section: Bioimagingmentioning

confidence: 99%

Near‐Infrared Fluorophores Based on Heptamethine Cyanine Dyes: From Their Synthesis and Photophysical Properties to Recent Optical Sensing and Bioimaging Applications

et al. 2022

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This review summarizes diverse synthetic methodologies to prepare a wide range of heptamethine cyanine dyes, including symmetrical, unsymmetrical, and meso‐substituted derivatives, and their photophysical properties and uses. Their sensing applications are also discussed, considering the nature of their electronic structures and photophysical properties. The optical sensing applications of these compounds can be potentially expanded via structural modification, broadening their absorption amplitude and spectral emission range from the ultraviolet to near‐infrared (NIR) region. In this review, several recent practical applications of the heptamethine cyanine dyes for ion and small molecule sensing, as well as bioimaging, are covered and discussed.

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“…After this seminal study, aryl boronic acid-capped fluorophores remain a prevalent strategy in the selective detection of H 2 O 2 . Recent advances include detection of H 2 O 2 in ischemia-reperfusion injury (20), chemiluminescent detection through a capped luciferin substrate (21), and the use of boronate-capped probes that trigger 1,6-elimination reactions on phenol generation (20).…”

Section: Sulfonylsmentioning

confidence: 99%

Advances in Imaging Reactive Oxygen Species

Espinoza

Røise

et al. 2020

J Nucl Med

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Reactive oxygen species (ROS) play a pivotal role in many cellular processes and can be either beneficial or harmful. The design of ROS-sensitive fluorophores has allowed for imaging of specific activity and has helped elucidate mechanisms of action for ROS. Understanding the oxidative role of ROS in the many roles it plays allows us to understand the human body. This review provides a concise overview of modern advances in the field of ROS imaging. Indeed, much has been learned about the role of ROS throughout the years; however, it has recently been shown that using nanoparticles, rather than individual small organic fluorophores, for ROS imaging can further our understanding of ROS.

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A near-infrared fluorescent probe for evaluating endogenous hydrogen peroxide during ischemia/reperfusion injury

Abstract: A fluorescent probe, Cy-ArB, is developed for real-time monitoring of H2O2 fluctuations in cells and in vivo during ischemia/reperfusion processes.

Cited by 27 publications

References 56 publications

Nanoarchitectonics of Cartilage-Targeting Hydrogel Microspheres with Reactive Oxygen Species Responsiveness for the Repair of Osteoarthritis

Nanoarchitectonics of Cartilage-Targeting Hydrogel Microspheres with Reactive Oxygen Species Responsiveness for the Repair of Osteoarthritis

Near‐Infrared Fluorophores Based on Heptamethine Cyanine Dyes: From Their Synthesis and Photophysical Properties to Recent Optical Sensing and Bioimaging Applications

Advances in Imaging Reactive Oxygen Species

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