A neurochemical study of thiosemicarbazide seizures and their inhibition by amino-oxyacetic acid

Roa, P. D.; Tews, Jean K.; Stone, W. E.

doi:10.1016/0006-2952(64)90168-6

Cited by 56 publications

(7 citation statements)

References 21 publications

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“…Only the amount of cystathionine, which is an important component of membrane proteins, remains comparatively stable. Discussions of why glycine, alanine, and threonine contents increase during prolonged seizures have been either avoided (Mutani et al, 1977) or attributed to unspecific metabolic alterations (Roa et al, 1964;Tews and Stone, 1965;Chapman et al, 1977). Uptake from the blood has been suggested as a possible mechanism (Battistin et al, 1975).…”

Section: Regionmentioning

confidence: 99%

Alterations in the Content of Amino Acid Neurotransmitters Before the Onset and During the Course of Methoxypyridoxine‐Induced Seizures in Individual Rabbit Brain Regions

Nitsch

Schmude

Haug

1983

Journal of Neurochemistry

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In rabbits, generalized seizures were induced by methoxypyridoxine, and changes in amino acid concentrations of 15 brain regions were investigated before seizure onset and during the course of sustained epileptiform activity. As previously reported, gamma-aminobutyric acid (GABA) concentration decreased preictally in most regions. At the same time, taurine level was elevated in the hypothalamus, thalamus, hippocampus, caudatum, and frontal cortex. After 90 min of seizures, it was significantly decreased in the hypothalamus, periaqueductal grey, substantia nigra, frontal cortex, and cerebellum. Glycine content was reduced preictally only in the substantia nigra; after seizure onset its concentration rose in all brain areas. Glutamate content in the frontal cortex decreased before seizure onset; after 1.5 h of seizures, its concentration in cerebellum, caudatum, and hippocampus was reduced. Aspartate level was decreased in most areas after sustained seizures; in putamen, however, it was elevated. In contrast, glutamine content increased preictally in the superior colliculus and in all brain areas by approximately 200% after 90 min of seizures. Alanine and valine content also rose markedly in most brain areas after prolonged seizures, and threonine showed the same tendency. The single brain regions were observed to respond to methoxypyridoxine in highly individualistic ways. For example, the glycine content of the substantia nigra, which is believed to utilize this amino acid as a neurotransmitter, decreased preictally. The potential importance of the superior colliculus in seizure induction is considered in view of the early rise in glutamine level. The antagonistic preictal behavior of taurine and GABA is discussed with respect to synthesis, uptake from the blood, and antiepileptic properties.

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Section: Regionmentioning

confidence: 99%

Alterations in the Content of Amino Acid Neurotransmitters Before the Onset and During the Course of Methoxypyridoxine‐Induced Seizures in Individual Rabbit Brain Regions

Nitsch

Schmude

Haug

1983

Journal of Neurochemistry

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“…In chicks, as in other species Da Vanzo, Greig & Cronin, 1961Da Vanzo, Matthews, Young & Wingerson, 1964Roa, Tews & Stone, 1964;Kuriyama, Roberts & Rubinstein, 1966), AOAA had convulsant and at lower doses anticonvulsant properties. AOAA also controls some seizures in man (Carter, 1964).…”

Section: Discussionmentioning

confidence: 75%

“…AOAA inhibits pyridoxal dependent enzyme systems such as GABAT (Hopper & Segal, 1962) and pyridoxal kinase (Da Vanzo, Kang, Ruchkart & Dougherty, 1966). It also increases glutamine and decreases succinic semialdehyde concentrations in brain (Wallach, 1959 ;Wallach, 1968;Roa, Tews & Stone, 1964). Baxter & Roberts (1961) have, however, shown that AOAA does not inhibit glutamic decarboxylase activity in vivo.…”

Section: Discussionmentioning

confidence: 99%

Pharmacological properties of amino‐oxyacetic acid in the chicken

Osuide

1972

British J Pharmacology

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Summary1. The effects of amino-oxyacetic acid (AOAA) on the central nervous system and on skeletal muscle have been examined in the chicken. 2. AOAA had both anticonvulsant and convulsant effects, depending on the dose, as in other species. 3. The convulsant effect, accompanied by EEG spiking, decreased rapidly with increase in age of young chicks. 4. The convulsant effect was exerted primarily through supraspinal centres.5. Of control depressants tested, only troxidone and small doses of AOAA afforded significant protection against AOAA seizures.

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“…AOA binds covalently to pyridoxal phosphate and acts as a nonspecific transaminase inhibitor (Dante Roa et al, 1964;Wood and Peesker, 1973). AOA is also known to decrease the odor of cut flowers of Lilium cv.…”

Section: Odor Control By Chemical Treatmentmentioning

confidence: 99%

Odor Components and the Control of Odor Development in Ornamental Cabbage

Kishimoto

Maeda²,

Haketa³

et al. 2014

J. Japan. Soc. Hort. Sci.

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Ornamental cabbage (Brassica oleracea var. acephala f. tricolor) cultivars of Japanese seed companies are grown in Europe. Unpleasant odors from cut flowers have become a problem in this region. We investigated volatiles emitted from cut flowers of 'Hatsubeni' and 'Haresugata', two major Japanese ornamental cabbage cultivars in Europe, by gas chromatography-mass spectrometry (GC-MS). Dimethyl disulfide was identified as the major odor-active component emerging from plants as well as from vase water. Vase water was a major source of unpleasant scents, and odor development was prevented by changing the water frequently. We tested the effects of potential suppressors of dimethyl disulfide emission from cut flowers applied to vase water. Cyprodinil, an inhibitor of the synthesis of dimethyl disulfide from methionine, and aminooxyacetic acid, an inhibitor of enzymatic reactions involved in dimethyl disulfide biosynthesis, did not show any effects. In contrast, isothiazolinonic germicide, a cut-flower preservative, inhibited the rot of cut ends of flower stems and reduced dimethyl disulfide emission from cut flowers by 30-40%. In addition, this germicide significantly inhibited emissions from vase water. Isothiazolinonic germicide is a promising candidate inhibitor of unpleasant scents from cut flowers of ornamental cabbage.

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A neurochemical study of thiosemicarbazide seizures and their inhibition by amino-oxyacetic acid

Cited by 56 publications

References 21 publications

Alterations in the Content of Amino Acid Neurotransmitters Before the Onset and During the Course of Methoxypyridoxine‐Induced Seizures in Individual Rabbit Brain Regions

Alterations in the Content of Amino Acid Neurotransmitters Before the Onset and During the Course of Methoxypyridoxine‐Induced Seizures in Individual Rabbit Brain Regions

Pharmacological properties of amino‐oxyacetic acid in the chicken

Odor Components and the Control of Odor Development in Ornamental Cabbage

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