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The effects of tyramine on polysynaptic spinal reflexes in anaesthetised chicks and cats have been studied. Very large intravenous doses of tyramine depressed the reflexly evoked contractions of skeletal muscles by an action exerted in the spinal cord. Since tyramine is normally present in the central nervous system, its function may be to exert some inhibitory controlling influence on muscular activity.

Summary1. The effects of amino-oxyacetic acid (AOAA) on the central nervous system and on skeletal muscle have been examined in the chicken. 2. AOAA had both anticonvulsant and convulsant effects, depending on the dose, as in other species. 3. The convulsant effect, accompanied by EEG spiking, decreased rapidly with increase in age of young chicks. 4. The convulsant effect was exerted primarily through supraspinal centres.5. Of control depressants tested, only troxidone and small doses of AOAA afforded significant protection against AOAA seizures.