A new butenolide cinnamate and other biological active chemical constituents fromPolygonum glabrum

Said, Madhukar S.; Chinchansure, Ashish A.; Nawale, Laxman; Durge, Ankita; Wadhwani, Ashish; Kulkarni, Smita; Sarkar, Dhiman; Joshi, Suchitra

doi:10.1080/14786419.2015.1004674

Cited by 20 publications

(10 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The present study is also in accordance with the previous reports since an increase in LDH and SGOT enzymes are observed in isoproterenol treated groups. [2,3-dihydroxy isodrimeninol] etc, administration of this extract might prevent the leakage of biomarkers in to blood stream by stabilizing the membranes [13]. The quantity and composition of lipids in the myocardium is also a determinative factor for development of cardiovascular disease.…”

Section: Discussionmentioning

confidence: 99%

“…The methanol extract showed maximum antimicrobial activity against pathogens such as Staphylococcus aureus, Micrococcus luteus, Candida tropicalis etc [12]. Substantial literature survey suggested that many phytoconstituents such as (2)-2-methoxy-2-butenolide-3cinnamate, beta-hydroxyfriedalanol, 3-hydroxy-5-methoxystilbene, pinocembrin, sitosterol-(6α-O-palmitoyl)-3-O-β-Dglucopyranoside, pinocembrin-5-methyl ether and sitosterol-3-O-βDglucopyranoside were isolated from Polygonum glabrum [13]. Other flavonoids (avicularin, rhamnetin, diosmetin, cyanidin 3 5-diglucoside, delphinidin 3,5, diglucoside) and sesqueterpene diesters were isolated from methanol extract of leaves and flowers of Polygonum glabrum [14,15]…”

Section: Ecrosis In Ratsmentioning

confidence: 99%

See 1 more Smart Citation

Cardioprotective Potential of Methanol Extract of Polygonum glabrum on Isoproterenol Induced Myocardial Necrosis in Rats

Raja¹,

Ramya²

2017

ijpm

View full text Add to dashboard Cite

Aim: The aim of present study was to evaluate the cardioprotective efficacy of Polygonum glabrum on isoproterenol induced myocardial necrosis in rats. Methods: Experimental rats were treated orally with methanol extract of Polygonum glabrum at two doses (200 mg and 400 mg/kg) for 30 days. Isoproterenol (85 mg/kg, s.c.) was administered on 29th and 30th day to induce myocardial necrosis. At the end of the experiment, serum cardiac marker enzymes [creatine kinase muscle brain (CK-MB), lactate dehydrogenase (LDH), serum glutamate oxaloacetate transaminase (SGOT)], serum glutamate pyruvate transaminase (SGPT) and total protein (TP) were estimated. Plasma total cholesterol (TC), triglycerides (TG), high density lipoprotein (HDL), low density lipoprotein (LDL) and very low density lipoprotein (VLDL) levels were also recorded. Further, antioxidant parameters viz catalase (CAT), superoxide dismutase (SOD), glutathione (GSH), glutathione peroxidase (GPx), glutathione reductase (GRD) and malondialdehyde (MDA) levels were evaluated in heart tissue homogenate. Results: The results of the study indicated that, methanol extract of Polygonum glabrum showed greater cardioprotection by restoring the cardiac marker enzymes and attenuated the level of plasma lipid profiles along with an increase in HDL. Additionally, level of myocardial antioxidants significantly increased along with a reduction in the content of malondialdehyde. The cardioprotective effect was compared with propranolol (10 mg/kg, oral) which was used as the standard. Histopathological findings revealed a decrease in the degree of necrosis and inflammation following pretreatment with Polygonum glabrum. Conclusion: The present investigation indicates that Polygonum glabrum could protect myocardium from isoproterenol induced necrosis.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Ecrosis In Ratsmentioning

confidence: 99%

Cardioprotective Potential of Methanol Extract of Polygonum glabrum on Isoproterenol Induced Myocardial Necrosis in Rats

Raja¹,

Ramya²

2017

ijpm

View full text Add to dashboard Cite

show abstract

“…Rosmarinic acid is a polyphenolic compound from the plant Prunella vulgaris, usedfor the treatment of isolated HIV [378]. From Polygonum glabrum, various bioactive constituents with antiretroviral activities have been reported, e.g., (-)-2-methoxy-2-butenolide-3-cinnamate, pinocembrin (96), 3-hydroxy-5-methoxystilbene (97), sitosterol-3-O-β-D-glucopyranoside, and pinocembrin-5-methyl ether [379]. Actein (98) from the rhizomes of Cimicifuga racemosa, possessed a significant activity against HIV [380].…”

Section: Miscellaneous Plant-based Anti-hiv Agentsmentioning

confidence: 99%

Structure-Activity-Relationship and Mechanistic Insights for Anti-HIV Natural Products

et al. 2020

View full text Add to dashboard Cite

Acquired Immunodeficiency Syndrome (AIDS), which chiefly originatesfroma retrovirus named Human Immunodeficiency Virus (HIV), has impacted about 70 million people worldwide. Even though several advances have been made in the field of antiretroviral combination therapy, HIV is still responsible for a considerable number of deaths in Africa. The current antiretroviral therapies have achieved success in providing instant HIV suppression but with countless undesirable adverse effects. Presently, the biodiversity of the plant kingdom is being explored by several researchers for the discovery of potent anti-HIV drugs with different mechanisms of action. The primary challenge is to afford a treatment that is free from any sort of risk of drug resistance and serious side effects. Hence, there is a strong demand to evaluate drugs derived from plants as well as their derivatives. Several plants, such as Andrographis paniculata, Dioscorea bulbifera, Aegle marmelos, Wistaria floribunda, Lindera chunii, Xanthoceras sorbifolia and others have displayed significant anti-HIV activity. Here, weattempt to summarize the main results, which focus on the structures of most potent plant-based natural products having anti-HIV activity along with their mechanisms of action and IC50 values, structure-activity-relationships and important key findings.

show abstract

“…Rosmarinic acid is a polyphenolic compound that is isolated from the plant Prunella vulgaris, is used for the anti-HIV potential [366]. ether [367]. Actein (98) is extracted from the rhizomes of plant Cimicifuga racemosa, has possessed significant activity against the HIV virus [368].…”

Section: Miscellaneous Plants Used As Anti-hiv Agentsmentioning

confidence: 99%

Structure-Activity Relationship and Mechanistic Insights for Anti-HIV Natural Products

Kaur

Sharma

Gupta³

et al. 2020

Preprint

View full text Add to dashboard Cite

Acquired Immunodeficiency Syndrome (AIDS) which is chiefly originated by a retrovirus named Human Immunodeficiency Virus (HIV), has influenced about 70 million populations worldwide. Even though several advancements have been invented in the field of antiretroviral combination therapy, still HIV has become the dominant reason for death in South Africa, for example. The current antiretroviral therapies have achieved success in providing instant HIV suppression but with countless undesirable adverse effects. In the present day, the biodiversity of the plant kingdom is being explored by several researchers for the discovery of potent anti-HIV drugs with different mechanisms of action. The primary challenge is to afford a treatment that is free from any sort of risk of drug resistance and serious side effects. Hence, there is a strong demand to evaluate the drugs obtained from natural plants as well as the synthetic derivatives that have been derived from the natural compounds by various chemical reactions. Several plants such as Andrographis paniculata, Dioscorea bulbifera, Aegle marmelos, Wistaria floribunda, Lindera chunii, Xanthoceras sorbifolia and others have displayed significant anti-HIV activity showing more potent anti-HIV activity along with their structures, SARs & important key findings.

show abstract

A new butenolide cinnamate and other biological active chemical constituents fromPolygonum glabrum

Cited by 20 publications

References 16 publications

Cardioprotective Potential of Methanol Extract of <em>Polygonum glabrum</em> on Isoproterenol Induced Myocardial Necrosis in Rats

Cardioprotective Potential of Methanol Extract of <em>Polygonum glabrum</em> on Isoproterenol Induced Myocardial Necrosis in Rats

Structure-Activity-Relationship and Mechanistic Insights for Anti-HIV Natural Products

Structure-Activity Relationship and Mechanistic Insights for Anti-HIV Natural Products

Contact Info

Product

Resources

About