A New Diagnostic Test for Acute Myocardial Infarction

Saranchak, Harry J.

doi:10.1001/jama.1974.03230350023020

Cited by 40 publications

(5 citation statements)

References 12 publications

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“…High myoglobin concentrations in urine, myoglobinuria, are caused by muscle cramps, excessive unaccustomed exercise, trauma, infection, and the toxin from sea snake bite (3). High myoglobin concentrations in serum, myoglobinemia, and myoglobinuria are indicators for myocardial infarction (4,5). Recent results indicate that myoglobinemia is the earliest serum indicator of myocardial infarction and is possibly more useful than creatine kinase or lactate dehydrogenase in diagnosing this disease (6)(7)(8).…”

mentioning

confidence: 99%

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Reversible heterogeneous reduction and oxidation of sperm whale myoglobin at a surface modified gold minigrid electrode

Stargardt¹,

Hawkridge²,

Landrum³

1978

Anal. Chem.

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confidence: 99%

“…Normal serum myoglobin concentrations are 10 to 68 gg/L. Myoglobinuria and myoglobinemia are most selectively and sensitively determined by radioimmunoassay procedures (5)(6)(7)(8). These procedures are sophisticated and require several hours of analysis time.…”

mentioning

confidence: 99%

Reversible heterogeneous reduction and oxidation of sperm whale myoglobin at a surface modified gold minigrid electrode

Stargardt¹,

Hawkridge²,

Landrum³

1978

Anal. Chem.

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“…In several studies, single daily samples only were tested (Levine et al, 1971;Saranchak and Bernstein, 1974). Kessler and his associates (1975) examined samples of all urine passed in the first 24 hours, with analysis of single random samples over the next 3 days.…”

Section: Discussionmentioning

confidence: 99%

“…It has been shown recently that after acute myocardial infarction, myoglobin is released from damaged heart muscle into the blood stream and is then cleared rapidly from the circulation and excreted in the urine (Kagen, 1973). Several studies have indicated that the detection of myoglobin in the urine may be a useful additional test in the diagnosis of acute myocardial necrosis in man (Strausser, Rothfeld, and Bucsi, 1966;Adams and Elliott, 1970;Levine et al, 1971;Saranchak and Bernstein, 1974;Kessler et al, 1975). If the total amount is related to the amount of muscle necrosis, then measurements of myoglobinuria could be relevant to an understand-Received for publication 8 July 1976 ing of the evolution of the infarction process.…”

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confidence: 99%

Excretion of myoglobin in urine after actue myocardial infarction.

Donald¹,

Cloonan²,

Neale³

et al. 1977

Heart

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We studied myoglobin excretion in 33 patients admitted to the coronary care unit with a provisional diagnosis of acute myocardial infarction. Sixteen proved to have definite and uncomplicated acute myocardial infarction and 17 possible infarction, using WHO criteria. For 5 days after admission, aliquots of every urine specimen voided by each patient were analysedfor myoglobin using an immunochemical method able to detect a minimum urinary myoglobin concentration of 0-02 mg/ml. Myoglobinuria was detected in 14 of the 16 patients with definite infarction but was not found in any of the 1 7 patients with possible infarction. There were 3 patterns of myoglobin excretion. In 8 of the 14 patients it was excreted in one episode starting 10 to 40 hours after the onset of chest pain and lasting for 5 to 45 hours. In 3 of the remaining patients it was excreted over a much longer period (mean 83 hours) and in the final 3 patients myoglobinuria occurred in 2 or 3 intermittent episodes with periods of between 10 and 20 hours during which it was not detected. Total myoglobin excretion, which varied between 2 and 100 mg (mean 51 mg), did not correlate with peak serum enzyme levels. We concluded that in the appropriate clinical setting, the finding of myoglobinuria provides additional evidence for a diagnosis of acute myocardial infarction. The variable myoglobin excretion pattern suggests that in seemingly uncomplicated myocardial infarction there is considerable variation between patients in the pattern of evolution of the infarction process. This may be relevant to the assessment of measures directed towards limiting infarct size.

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“…Myoglobinuria has been proved as the earliest detectable biochemical parameter after myocardial infarction [4,7,13,14]. Following accidents and atraumatic rhabdomyolysis with a marked myoglobinuria Mb is potentially tubulotoxic as seen by a high incidence of acute kidney failure [3].…”

Section: Introductionmentioning

confidence: 99%

Human myoglobin: Preparation, quantitation and standardization

Boesken

Mamier

1977

Res. Exp. Med.

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The quantitation of myoglobin (Mb) in serum and urine is of clinical importance for the differentiation of myocardial infarction from degenerative cardiac disorders as well as for the detection of traumatic and atraumatic rhabdomyolysis, followed frequently by acute kidney failure. A simple method is described to prepare myoglobin from human muscle extract by negative pressure ultrafiltration and dialysis. By a combination of electrophoretic procedures, this preparation was analysed for purity. Saline myoglobin solutions after deep freezing loose rapidly their immunoreactive Mb content. By addition of pure albumin, not containing heme binding proteins, a stable Mb solution was obtained. This has been used as standard (5--50 microgram/ml) in radial immunodiffusion sensitive for detecting 0.2--1 microgram Mb/ml.

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A New Diagnostic Test for Acute Myocardial Infarction

Cited by 40 publications

References 12 publications

Reversible heterogeneous reduction and oxidation of sperm whale myoglobin at a surface modified gold minigrid electrode

Reversible heterogeneous reduction and oxidation of sperm whale myoglobin at a surface modified gold minigrid electrode

Excretion of myoglobin in urine after actue myocardial infarction.

Human myoglobin: Preparation, quantitation and standardization

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