A New Insight on the Radioprotective Potential of Epsilon-Aminocaproic Acid

Abstract

Background and objectives: The aim of the study was to scrutinize the ability of epsilon-aminocaproic acid (EACA) to prevent radiation-induced damage to human cells. Materials and Methods: Human peripheral blood mononuclear cells (PBMCs) were exposed to ionizing radiation at three low doses (22.62 mGy, 45.27 mGy, and 67.88 mGy) in the presence of EACA at the concentration of 50 ng/mL. Results: EACA was able to prevent cell death induced by low-dose X-ray radiation and suppress the formation of reactive oxygen species (ROS). EACA also demonstrated a capacity to protect DNA from radiation-induced damage. The data indicated that EACA is capable of suppression of radiation-induced apoptosis. Comparative tests of antioxidative activity of EACA and a range of free radical scavengers showed an ability of EACA to effectively inhibit the generation of ROS. Conclusions: This study showed that the pretreatment of PBMCs with EACA is able to protect the cells from radiation-elicited damage, including free radicals’ formation, DNA damage, and apoptosis.

Polygonum odoratum leaf extract attenuates oxidative stress and cell death of Raw 264.7 cells exposed to low dose ionizing radiation

“…Recently, it has been reported that the natural active compounds exhibited the radioprotective effect and protected against excessive oxidative stress and cell death caused by ionizing radiation (Jagetia, 2007;Smith et al, 2017). In addition, several lines of evidence have been reported for the radioprotective effect of polyphenol-rich extract in living organisms by promoting cell viability and preventing cell apoptosis (Kim et al, 2008;Saliev et al, 2020).…”

“…Recently, it has been reported that the natural active compounds exhibited the radioprotective effect and protected against excessive oxidative stress and cell death caused by ionizing radiation (Jagetia, 2007; Smith et al., 2017). In addition, several lines of evidence have been reported for the radioprotective effect of polyphenol‐rich extract in living organisms by promoting cell viability and preventing cell apoptosis (Kim et al., 2008; Saliev et al., 2020). The possible underlying mechanisms might be exhibited via the inhibition of ROS production (Materska et al., 2015), lipid peroxidation (Uma Devi et al, 2000), enhancement of scavenging enzymes activity (Georgieva et al., 2013), protection from DNA damage (Cinkilic et al., 2013), and increment of immunomodulatory potential (El‐Desouky et al., 2017).…”