A New Intrinsic Hypoxia Marker in Esophageal Cancer

Ding, Ivan; Okunieff, Paul; Liu, Weimin; Fenton, Bruce M.; Salnikow, Konstantin

doi:10.1007/978-1-4757-6125-2_32

Cited by 3 publications

(1 citation statement)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Based on UniGene cluster analysis, the NDRG2 gene is located at chromosome 14q11.2 and is closely related to NDRG1 (Qu et al 2002). NDRG1 has been linked to stress responses (Park et al 2000;Agarwala et al 2000;Salnikow et al 2002;Ding et al 2003;Cangul 2004), cell proliferation (Piquemal et al 1999;Kim et al 2004;Sugiki et al 2004;Malette et al 2003), differentiation (Guan et al 2000;Gomez-Casero et al 2001;Li and Kretzner 2003;Burchfield et al 2004), and apoptosis (Stein et al 2004). NDRG2 is the physiological substrate for serum/glucocorticoid-induced kinase 1 (Murray et al 2004), a novel insulin-dependent phosphoprotein (Burchfield et al 2004) and a novel mineralocorticoid-specific mediator of early physiological response to aldosterone in target tight epithelia (Boulkroun et al 2002).…”

Section: Introductionmentioning

confidence: 97%

Expression analysis of the NDRG2 gene in mouse embryonic and adult tissues

Liu

Deng

et al. 2006

Cell Tissue Res

View full text Add to dashboard Cite

N-myc downstream-regulated gene 2 (NDRG2) is believed to be involved in cell growth events. However, its exact function is still unknown. To elucidate the role of this gene, we used an anti-Ndrg2 monoclonal antibody in immunohistochemistry and immunofluorescence assays to analyze the expression pattern of Ndrg2 protein in mouse embryos at various gestational ages and in a variety of adult mouse tissues. Ndrg2 immunoreactivity was generally localized to the cytoplasm. During mouse development, Ndrg2 expression was observed in many developing tissues and organs including the heart, brain, lung, gut, liver, kidney, skeletal muscle, cartilage, chorion, epidermis, and whisker follicles. Ndrg2 expression was developmentally dynamic, being generally lower in the early stages of development and markedly increasing during later stages. Ndrg2 expression was also observed in a variety of adult mouse tissues, particularly in the heart and brain. This is the first demonstration of Ndrg2 protein expression in both embryonic and adult mouse tissues. Our results suggest that NDRG2 plays important roles in histogenesis and organogenesis.

show abstract

Section: Introductionmentioning

confidence: 97%

Expression analysis of the NDRG2 gene in mouse embryonic and adult tissues

Liu

Deng

et al. 2006

Cell Tissue Res

View full text Add to dashboard Cite

show abstract

Past, Present, and Future of Oxygen in Cancer Research

Okunieff¹,

Fenton²,

Chen³

2005

Advances in Experimental Medicine and Biology

View full text Add to dashboard Cite

The first pathologists, oncologists, and medical physicists were aware that tumors were populated by an aberrant vasculature. The classic observations of Thomlinson and Gray in the 1950's established that O2 diffusion distances caused tumor to grow in cords. Tumor necrosis was observed surrounding a Krogh cylinder of viable tumor. That work helped explain earlier work by Warburg, who demonstrated a predisposition for tumors to favor anaerobic respiration, and it became the basis for 5 decades of subsequent research aimed at improving tumor oxygenation at the time of radiation. The role of O2 in modifying radiation response was attributed exclusively to the reactive free radicals that can be formed when O2 is present. These radicals produce approximately three-fold more irreparable double strand breaks in DNA. Subsequently it became clear that tumor had nutritional insufficiencies in addition to hypoxia. Ischemic regions are hypoglycemic, acidotic, have poor penetration of drugs, increased interstitial pressure, and altered immunological states. Ischemic regions can have intermittent reflow and associated redox stress. The relative impact of O2 compared to these associated phenomenon, and the degree to which hypoxia causes or follows these associated physiologic stresses, have been studied in detail. ISOTT scientists are responsible for much of the elucidation of the specific effects of O2, ADP/ATP ratios, hypoglycemia, and acidosis on tumor responses to radiation and hyperthermia. Many questions still remain.

show abstract

Tumor Oxygen Measurements and Personalized Medicine

Okunieff

O’Dell

Zhang

et al. 2012

Advances in Experimental Medicine and Biology

View full text Add to dashboard Cite

Tumor hypoxia is probably the most important not yet measurable factor that predicts the outcome of cancer therapy. Hypoxic tumors are resistant to radiation, chemotherapy, and surgery. They signal tumor cells to grow, invade, survive cytotoxic-factor assault, and increase metastatic activity. Therapies aimed at reversing hypoxia-related treatment resistance or normalizing hypoxia are proven effective with level 1 evidence. The weak link remains the lack of satisfactory methods of measurement of tumor oxygenation.

show abstract

A New Intrinsic Hypoxia Marker in Esophageal Cancer

Cited by 3 publications

References 13 publications

Expression analysis of the NDRG2 gene in mouse embryonic and adult tissues

Expression analysis of the NDRG2 gene in mouse embryonic and adult tissues

Past, Present, and Future of Oxygen in Cancer Research

Tumor Oxygen Measurements and Personalized Medicine

Contact Info

Product

Resources

About