A New Liquid Human Milk Fortifier and Linear Growth in Preterm Infants

Moya, Fernando; Sisk, Paula M.; Walsh, Kelly; Berseth, Carol Lynn

doi:10.1542/peds.2011-3120

Cited by 97 publications

(144 citation statements)

References 29 publications

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“…Careful evaluation of growth in preterm infants is important because postnatal or extrauterine growth restriction, defined as the decline in growth status from birth percentiles often to ,10th percentile weight-for-age by hospital discharge, remains a substantial problem, 16,17,40 has a negative impact on outcomes, 9,41-43 is modifiable, 18,20,[44][45][46][47][48][49] and may not be identified without the appropriate assessment tools. 13,22 Although extrauterine growth restriction usually refers to weight growth restriction, it also affects head and especially length growth.…”

Section: Discussionmentioning

confidence: 99%

BMI Curves for Preterm Infants

et al. 2015

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BACKGROUND AND OBJECTIVES: Preterm infants experience disproportionate growth failure postnatally and may be large weight for length despite being small weight for age by hospital discharge. The objective of this study was to create and validate intrauterine weight-for-length growth curves using the contemporary, large, racially diverse US birth parameters sample used to create the Olsen weight-, length-, and head-circumference-for-age curves.METHODS: Data from 391 681 US infants (Pediatrix Medical Group) born at 22 to 42 weeks' gestational age (born in 1998-2006) included birth weight, length, and head circumference, estimated gestational age, and gender. Separate subsamples were used to create and validate curves. Established methods were used to determine the weight-for-length ratio that was most highly correlated with weight and uncorrelated with length. Final smoothed percentile curves (3rd to 97th) were created by the Lambda Mu Sigma (LMS) method. The validation sample was used to confirm results. RESULTS:The final sample included 254 454 singleton infants (57.2% male) who survived to discharge. BMI was the best overall weight-for-length ratio for both genders and a majority of gestational ages. Gender-specific BMI-for-age curves were created (n = 127 446) and successfully validated (n = 126 988). Mean z scores for the validation sample were ∼0 (∼1 SD).CONCLUSIONS: BMI was different across gender and gestational age. We provide a set of validated reference curves (gender-specific) to track changes in BMI for prematurely born infants cared for in the NICU for use with weight-, length-, and head-circumference-for-age intrauterine growth curves. WHAT'S KNOWN ON THIS SUBJECT:Preterm infants experience disproportionate growth failure postnatally and may be large weight for length despite being small weight for age by hospital discharge. There is no routinely used measure to quantify and monitor disproportionate growth in the NICU.WHAT THIS STUDY ADDS: BMI differs across gender and gestational age. We provide a set of validated reference curves to track changes in BMI for prematurely born infants for use with weight-, length-, and head-circumference-for-age intrauterine growth curves.

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Section: Discussionmentioning

confidence: 99%

BMI Curves for Preterm Infants

et al. 2015

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“…After screening the full-text articles according to the inclusion criteria, the final meta-analysis included five studies. [7][8][9][10]14 One study was of low quality (NOS score 6) 14 and four were of high quality (Modified Jadad score !4). Table 1 presents the characteristics of these five analysed studies.…”

Section: Characteristics Of the Included Studiesmentioning

confidence: 99%

“…Table 1 presents the characteristics of these five analysed studies. [7][8][9][10]14 A total of 352 infants were included in the five studies, with 178 in the control groups and 174 in the experimental groups. The experimental groups were fed with human milk supplemented with HMF containing a higherthan-standard protein level; and the control groups were fed with human milk supplemented with HMF containing standard protein.…”

Section: Characteristics Of the Included Studiesmentioning

confidence: 99%

“…6 Several studies have demonstrated that HMF containing an increased protein level is beneficial to infant growth. [7][8][9][10] A study undertaken at eight US hospitals demonstrated that HMFs containing both standard and higher protein levels were well-tolerated; and that the blood chemistries were normal and acceptable for the infants' ages. 9 The aim of the current meta-analysis was to determine whether HMF with a higher-than-standard protein content would benefit preterm infant growth.…”

Section: Introductionmentioning

confidence: 99%

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Human milk fortifier with high versus standard protein content for promoting growth of preterm infants: A meta-analysis

Liu

Dang

et al. 2015

J Int Med Res

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Objective: To compare the growth of preterm infants fed standard protein-fortified human milk with that containing human milk fortifier (HMF) with a higher-than-standard protein content. Methods: Published articles reporting randomized controlled trials and prospective observational intervention studies listed on the PubMed Õ , Embase Õ , CINAHL and Cochrane Library databases were searched using the keywords 'fortifier', 'human milk', 'breastfeeding', 'breast milk' and 'human milk fortifier'. The mean difference with 95% confidence intervals was used to compare the effect of HMF with a higher-than-standard protein content on infant growth characteristics. Results: Five studies with 352 infants with birth weight 1750 g and a gestational age 34 weeks who were fed human milk were included in this meta-analysis. Infants in the experimental groups given human milk with higher-than-standard protein fortifier achieved significantly greater weight and length at the end of the study, and greater weight gain, length gain, and head circumference gain, compared with control groups fed human milk with the standard HMF. Conclusions: HMF with a higher-than-standard protein content can improve preterm infant growth compared with standard HMF.

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“…Оптималь-ний склад цих продуктів спеціального харчування затверджений Європейським товариством гастро-ентерології та харчування дітей (ESPGAN). Вико-ристання спеціальної суміші для маловагових дітей дозволяє забезпечити підвищені харчові потреби за умови споживання мінімального об'єму рідини ен-терально [19,22].…”

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Analysis of the parameters of postnatal growth in infants with very low body weight at birth in neonatal intensive care and special care units

Shunko¹,

Bielova²,

Putkaradze³

et al. 2016

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АннотацияВ работе приведен анализ изменения липидного обмена у 120 больных при сочетании гастроэзофагеальной реф-люксной болезни и гипотиреоза в сравнении с больными гастроэзофагеальной рефлюксной болезнью без патологии щитовидной железы и практически здоровыми людьми. Отмечается прямая зависимость между уровнем ТТГ и уровнем общих липидов (r=0,797, р<0,05), липопротеидов низкой плотности (r=0,587, р<0,05) и индексом атероген-ности (r=0,739, р<0,05). Ключевые слова: гастроэзофагеальная рефлюксная болезнь, гипотиреоз, липидный обмен. Reva T.V. Bucovinian State Medical University THE CHANGES OF THE LIPID METABOLISM WHEN COMBINED WITH GASTROESOPHAGEAL REFLUX DISEASE AND HYPOTHYROIDISM SummaryThe change of the lipid metabolism in 120 patients with a combination of gastroesophageal reflux disease and hypothyroidism were compared with patients with gastroesophageal reflux disease without thyroid disease and healthy individuals. The author noted a direct correlation between TSH levels and the level of total lipids (r = 0,797, p <0.05), low density lipoproteins (r = 0,587, p <0.05) and atherogenic index (r = 0,739, p <0.05). Keywords: gastroesophageal reflux disease, hypothyroidism, lipid metabolism. Необхідність розробки та впровадження стратегій оптимального ентерального харчування глибоко недоношених не-мовлят визначається доведеним впливом якості раннього постнатального харчування на показники захворюваності, фізичного та нервово-психічного розвитку дітей у більш пізньому віці. На момент досягнення повного об'єму енте-рального харчування практично в усіх глибоко недоношених дітей із дуже малою та надзвичайно малою масою тіла є дефіцит споживання білків. Впровадження сучасних стратегій ентерального харчування глибоко недоношених дітей, а саме «агресивне» харчування, адекватне харчування, трофічне ентеральне харчування, застосування спеціальних харчових продуктів -збагачувачів грудного молока та спеціальних сумішей для вигодовування глибоко недоношених дітей, є резервом для покращення кінцевих результатів їх виходжування та віддалених наслідків. Ключові слова: ентеральне харчування, новонароджені, глибоко недоношені, дуже мала маса тіла, надзвичайно мала маса тіла, затримка постнатального фізичного розвитку © Шунько Є.Є., Бєлова О.О., Путкарадзе Р.В., 2015 П остановка проблеми. З першого січня 2007 року Україна впровадила світові стандар-ти реєстрації новонароджених з 22 тижнів геста-ції та маси тіла при народженні 500 грам. За 2012 рік в Україні народилось 3760 дітей з дуже малою масою тіла (ДММТ) -менше 1500 грам; та 1270 дітей з надзвичайно малою масою тіла (НММТ) -менше 1000 грам. Когорта глибоко недоношених дітей (до 32 тижнів гестації) з ДММТ та НММТ має найбільший ризик смерті, захворюваності та інвалідізації серед усіх новонароджених. При-чому для хлопчиків ризик негативних наслідків передчасного народження більший, ніж для ді-вчаток [16]. Плід з 28 тижня до 38-40 тижня гес-тації потроює масу тіла, а маса головного мозку за цей час збільшується вп'ятеро. Ефективне ен-теральне харчування має важливе значення дл...

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A New Liquid Human Milk Fortifier and Linear Growth in Preterm Infants

Abstract: Use of a new LHMF in preterm infants instead of powder HMF is safe. Benefits of LHMF include improvements in growth and avoidance of the use of powder products in the NICU.

Cited by 97 publications

References 29 publications

BMI Curves for Preterm Infants

BMI Curves for Preterm Infants

Human milk fortifier with high versus standard protein content for promoting growth of preterm infants: A meta-analysis

Analysis of the parameters of postnatal growth in infants with very low body weight at birth in neonatal intensive care and special care units

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