A new method of extraction of amoxicillin using mixed reverse micelles

Chuo, Sing Chuong; Mohd‐Setapar, Siti Hamidah; Mohamad-Aziz, Siti Norazimah; Starov, Victor

doi:10.1016/j.colsurfa.2014.03.107

Cited by 39 publications

(19 citation statements)

References 23 publications

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“…White precipitates were observed at alkaline conditions, which suggested that amoxicillin had denatured. Our previous study also reported similar observations 29 . Amoxicillin was reported to be most stable when pH of solution is kept near 6.0 30 and degradation of amoxicillin starts to occur at a faster rate when the solution pH is higher than 7.0 31 .…”

Section: Resultssupporting

confidence: 87%

“…Figure 7 shows the comparison between sophorolipids, AOT, and TWEEN 85 reverse micellar system for the forward extraction of amoxicillin. The results for AOT and TWEEN 85 surfactants were from our previous study 29 . Significant forward extraction of amoxicillin was achieved at much lower surfactant concentration when sophorolipids was used as compared to other surfactants.…”

Section: Resultsmentioning

confidence: 99%

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Reverse micelle Extraction of Antibiotics using an Eco-friendly Sophorolipids Biosurfactant

Chuo

Abd-Talib

Mohd‐Setapar

et al. 2018

Sci Rep

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Reverse micelles extraction of erythromycin and amoxicillin were carried out using the novel Sophorolipids biosurfactant. By replacing commonly used chemical surfactants with biosurfactant, reverse micelle extraction can be further improved in terms of environmental friendliness and sustainability. A central composite experimental design was used to investigate the effects of solution pH, KCl concentration, and sophorolipids concentration on the reverse micelle extraction of antibiotics. The most significant factor identified during the reverse micelle extraction of both antibiotics is the pH of aqueous solutions. Best forward extraction performance for erythromycin was found at feed phase pH of approximately 8.0 with low KCl and sophorolipids concentrations. Optimum recovery of erythromycin was obtained at stripping phase pH around 10.0 and with low KCl concentration. On the other hand, best forward extraction performance for amoxicillin was found at feed phase pH around 3.5 with low KCl concentration and high sophorolipids concentration. Optimum recovery of erythromycin was obtained at stripping phase pH around 6.0 with low KCl concentration. Both erythromycin and amoxicillin were found to be very sensitive toaqueous phase pH and can be easily degraded outside of their stable pH ranges.

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Section: Resultssupporting

confidence: 87%

Section: Resultsmentioning

confidence: 99%

Reverse micelle Extraction of Antibiotics using an Eco-friendly Sophorolipids Biosurfactant

Chuo

Abd-Talib

Mohd‐Setapar

et al. 2018

Sci Rep

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“…The simultaneous presence of an ionic and non-ionic surfactant conduct to the formation of mixed RMs and is specially proposed in order to reduce some drawbacks encountered in the case of each surfactant component alone, for instance to modify the polarity of the surfactant film and implicit of its surrounding microenvironment [31]. Exemplary mixed RMs are usually contain the well known anionic surfactant AOT together with either Span 60 [35], Tween 85 [39], Brij 30 [40,41] or the cationic surfactant CTAB with Tween 80 or Triton X-100 [41].…”

Section: Mixed Surfactants Compositionmentioning

confidence: 99%

Versatility of Reverse Micelles: From Biomimetic Model to Nano(Bio)Sensors Design

Arsene¹,

Gurban²,

Jecu³

et al. 2018

Preprint

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This paper presents an overview of the principal structural and dynamics characteristics of reverse micelles (RMs) in order to highlight their structural flexibility and versatility, along with the possibility to modulate their parameters in a controlled-manner. The multifunctionality in a large range of different scientific fields is exemplified in two distinct directions: a theoretical model for mimicry of biological microenvironment and practical application in the field of nanotechnology and nano-based sensors. RMs represents a convenient experimental approach that limits the drawbacks of the conventionally biological studies in vitro, while the particular structure confers them the status of simplified mimics of cells by reproducing a complex supramolecular organization in an artificial system. The biological relevance of RMs is discussed in some particular cases referring to the confinement and crowding environment, molecular dynamics of water and cell membrane structure. The use of RMs in different range of applications seems to be more promising due to their structural and compositional flexibility, a high efficiency and selectivity being achieved. The advance in nanotechnology is based on developing new methods of nanomaterials synthesis and deposition. This review highlighting the advantages of using RMs in synthesis of nanoparticles with specific properties and in nano (bio)sensors design.

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“…Also, their physicochemical behavior in surfactant/water system is much less studied than the conventional n-alkanes. Earlier, AOT/Tween-85 mixed RMs was successfully utilized for transdermal delivery of 5-fluorouracil, extraction of amoxicillin and topical delivery of Cyclosporin A [36][37][38]. But these formulated systems were mostly based on isopropyl myristate (IPM) or hydrocarbon oil.…”

Section: Introductionmentioning

confidence: 99%

The mixing behaviour of anionic and nonionic surfactant blends in aqueous environment correlates in fatty acid ester medium

Kundu

Das

Bardhan

et al. 2016

Colloids and Surfaces A: Physicochemical and Engineering Aspect

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A new method of extraction of amoxicillin using mixed reverse micelles

Cited by 39 publications

References 23 publications

Reverse micelle Extraction of Antibiotics using an Eco-friendly Sophorolipids Biosurfactant

Reverse micelle Extraction of Antibiotics using an Eco-friendly Sophorolipids Biosurfactant

Versatility of Reverse Micelles: From Biomimetic Model to Nano(Bio)Sensors Design

The mixing behaviour of anionic and nonionic surfactant blends in aqueous environment correlates in fatty acid ester medium

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