Reverse micelle Extraction of Antibiotics using an Eco-friendly Sophorolipids Biosurfactant

Abstract

Reverse micelles extraction of erythromycin and amoxicillin were carried out using the novel Sophorolipids biosurfactant. By replacing commonly used chemical surfactants with biosurfactant, reverse micelle extraction can be further improved in terms of environmental friendliness and sustainability. A central composite experimental design was used to investigate the effects of solution pH, KCl concentration, and sophorolipids concentration on the reverse micelle extraction of antibiotics. The most significant factor identified during the reverse micelle extraction of both antibiotics is the pH of aqueous solutions. Best forward extraction performance for erythromycin was found at feed phase pH of approximately 8.0 with low KCl and sophorolipids concentrations. Optimum recovery of erythromycin was obtained at stripping phase pH around 10.0 and with low KCl concentration. On the other hand, best forward extraction performance for amoxicillin was found at feed phase pH around 3.5 with low KCl concentration and high sophorolipids concentration. Optimum recovery of erythromycin was obtained at stripping phase pH around 6.0 with low KCl concentration. Both erythromycin and amoxicillin were found to be very sensitive toaqueous phase pH and can be easily degraded outside of their stable pH ranges.

Microbial Surfactants: The Next Generation Multifunctional Biomolecules for Applications in the Petroleum Industry and Its Associated Environmental Remediation

“…Apart from the petroleum industry, environmental remediation, and agriculture, biosurfactants are used in other industries, such as laundry detergents, medical/pharmaceuticals, food industry, textile, paint, leather, paper, mining, nanotechnology, bioprocessing, and recently in energy-saving technology [20,25,26,38,170,171,172,173,174,175,176,177,178,179,180,181,182,183,184,185]. The multifunctionality and application versatility lies in their properties (surface and interfacial tension reducing ability, low CMC, wettability, specificity, antimicrobial activity) and their advantages (environmental friendliness, biodegradability, biocompatibility, low toxicity, ease of production, chemical diversity, and cost-effectiveness).…”

“…Similarly, Balakrishnan et al [195] used biosurfactant to optimize the synthesis of polyethylene nanoparticles. The use of biosurfactant aided a reverse micelles system to recover antibiotics, enzymes, and proteins, which [170,180] is relatively new but shows high promise, with the potential for high-scale production and continuous operation. The application of biosurfactants in energy-saving technology with respect to eco-ice systems has been less publicized.…”

Biosurfactant trehalose lipid‐enhanced ultrasound‐assisted micellar extraction and determination of the main antioxidant compounds from functional plant tea

“…It is reported that these biosurfactants have been employed broadly for various applications covering industrial and environmental fields [7][8][9]. However, few extraction methods employing biosurfactants have been reported, limited to just the biodispersive liquid microextraction based on nano rhamnolipid aggregates [10] and the reverse micelle extraction of antibiotics using sophorolipids [11]. Trehalose lipid (Supporting Information Figure S1) is one kind of biosurfactant produced by some bacteria, and it possesses various biological and physicochemical properties, such as antitumour [12], antiviral, and antimicrobial activities [13].…”

Microbial Surfactants: The Next Generation Multifunctional Biomolecules for Diverse Applications

“…Apart from the petroleum industry, environmental remediation and agriculture, biosurfactants are used in other industries such as laundry detergents, medical/pharmaceuticals, food industry, textile, paint, leather, paper, mining, nanotechnology, bioprocessing, and recently in energy-saving technology [20,25,26,38,[170][171][172][173][174][175][176][177][178][179][180][181][182][183][184][185]. The multifunctionality and application versatility lies in their properties (surface and interfacial tension reducing ability, low CMC, wettability, specificity, antimicrobial activity) and their advantages (environmental friendliness, biodegradability, biocompatibility, low toxicity, ease of production, chemical diversity and cost-effectiveness).…”

“…Similarly, Balakrishnan et al [195] used biosurfactant to optimize the synthesis of polyethylene nanoparticles. The use of biosurfactant aided reverse micelles system to recover antibiotics, enzymes and proteins [170,180] is relatively new but shows high promise with a potential for high scale production and continuous operation. The application of biosurfactants in energy-saving technology with respect to eco-ice systems are less publicized.…”