A new phenolic glycoside from the Idesia polycarpa Maxim. leaves

Abstract

Phytochemical investigation on the ethyl acetate extract of Idesia polycarpa Maxim. leaves led to the isolation of four phenolic glycoside isomers (1-4). Compound 2 appeared to be new reported phenolic glycoside, while compound 1 was the first time isolated from the titled species. Their structures were established by IR, UV, HRESI-MS and 1D and 2D NMR spectroscopies analysis and comparison of spectral data with previously reported data. The compounds 3 and 4 showed stronger activity of scavenging the DPPH free radical than the other two compounds, while the compounds 1 and 2 showed a significant activity of scavenging the ABTS free radical. Compounds 2 and 4 exhibited stronger cytotoxicity against HepG2 cell lines compared to compounds 1 and 3. Moreover, compound 3 presented the highest cytotoxicity against MCF cell lines with IC 50 value of 37.17 ± 0.26 μg/mL than compounds 1, 2 and 4.

Amelioration by Idesia polycarpa Maxim. var. vestita Diels. of Oleic Acid-Induced Nonalcoholic Fatty Liver in HepG2 Cells through Antioxidant and Modulation of Lipid Metabolism

“…Interestingly, we found that EF-D mainly contained 1-[(4′-O-(Z)-p-coumaroyl)- β -D-glucopyranosyl]-oxy-2-phenol and 1-[(4′-O-(E)-p-coumaroyl)- β -D-glucopyranosyl]-oxy-2-phenol [ 35 ] ( Figure 7 ). We identified the two compounds by comparing to the standard substances which were isolated from the defatted fruit of I. polycarpa and identified by mass spectrometry in our laboratory [ 36 ]. The antioxidant activities and cell cytotoxicity of two new monomers have been proven [ 36 ].…”

“…We identified the two compounds by comparing to the standard substances which were isolated from the defatted fruit of I. polycarpa and identified by mass spectrometry in our laboratory [ 36 ]. The antioxidant activities and cell cytotoxicity of two new monomers have been proven [ 36 ]. Our findings are consistent with the previous studies and demonstrate that the defatted fruit of I. polycarpa acts as a natural product for ameliorating NAFLD.…”