A new production method of elastic silicone carotid phantom based on MRI acquisition using rapid prototyping technique

Cao, Peng; Duhamel, Yvan; Olympe, Guillaume; Ramond, Bruno; Langevin, François

doi:10.1109/embc.2013.6610753

Cited by 13 publications

(3 citation statements)

References 8 publications

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“…In recent decades, in vitro vascular models, primarily made from silicone, have been fabricated to replicate the anatomical 9 , 18 , mechanical 31 , 32 , and biological 33 , 34 properties of natural vessels. Therefore, several patient-specific vascular models have been created to study flow characteristics in diseased vessel regions, such as stenosis and aneurysms, and to evaluate the effects of their treatments by means of catheter systems and implants 9 , 35 .…”

Section: Discussionmentioning

confidence: 99%

Fabrication, characterization and numerical validation of a novel thin-wall hydrogel vessel model for cardiovascular research based on a patient-specific stenotic carotid artery bifurcation

Shiravand,

Richter,

Willmann

et al. 2024

Sci Rep

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In vitro vascular models, primarily made of silicone, have been utilized for decades for studying hemodynamics and supporting the development of implants for catheter-based treatments of diseases such as stenoses and aneurysms. Hydrogels have emerged as prominent materials in tissue-engineering applications, offering distinct advantages over silicone models for fabricating vascular models owing to their viscoelasticity, low friction, and tunable mechanical properties. Our study evaluated the feasibility of fabricating thin-wall, anatomical vessel models made of polyvinyl alcohol hydrogel (PVA-H) based on a patient-specific carotid artery bifurcation using a combination of 3D printing and molding technologies. The model’s geometry, elastic modulus, volumetric compliance, and diameter distensibility were characterized experimentally and numerically simulated. Moreover, a comparison with silicone models with the same anatomy was performed. A PVA-H vessel model was integrated into a mock circulatory loop for a preliminary ultrasound-based assessment of fluid dynamics. The vascular model's geometry was successfully replicated, and the elastic moduli amounted to 0.31 ± 0.007 MPa and 0.29 ± 0.007 MPa for PVA-H and silicone, respectively. Both materials exhibited nearly identical volumetric compliance (0.346 and 0.342% mmHg−1), which was higher compared to numerical simulation (0.248 and 0.290% mmHg−1). The diameter distensibility ranged from 0.09 to 0.20% mmHg−1 in the experiments and between 0.10 and 0.18% mmHg−1 in the numerical model at different positions along the vessel model, highlighting the influence of vessel geometry on local deformation. In conclusion, our study presents a method and provides insights into the manufacturing and mechanical characterization of hydrogel-based thin-wall vessel models, potentially allowing for a combination of fluid dynamics and tissue engineering studies in future cardio- and neurovascular research.

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Section: Discussionmentioning

confidence: 99%

Fabrication, characterization and numerical validation of a novel thin-wall hydrogel vessel model for cardiovascular research based on a patient-specific stenotic carotid artery bifurcation

Shiravand,

Richter,

Willmann

et al. 2024

Sci Rep

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“…Phantoms are used to reproduce in vivo conditions and verify theoretical models. They can reproduce wall deformations 25,26 , mimicking dynamic viscoelasticity and friction resistance of blood vessels 13,24 , under systemic pressure with a cardiac pump. Steering microrobots across multiple bifurcations in phantoms has already been investigated, 7,8,10,15 but disregarded the effect of the gravitational force, the friction force, the curvature of the vessel innerwall, and the pulsatile flow with systemic pressure, all acting on the steering success.…”

Section: Introductionmentioning

confidence: 99%

Navigation of Microrobots by MRI: Impact of Gravitational, Friction and Thrust Forces on Steering Success

Tous

Dimov

et al. 2021

Ann Biomed Eng

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Introduction Magnetic resonance navigation (MRN) uses MRI gradients to steer magnetic drug-eluting beads (MDEBs) across vascular bifurcations. We aim to experimentally verify our theoretical forces balance model (gravitational, thrust, friction, buoyant and gradient steering forces) to improve the MRN targeted success rate. Method A single-bifurcation phantom (3 mm inner diameter) made of poly-vinyl alcohol was connected to a cardiac pump at 0.8 mL/s, 60 beats/minutes with a glycerol solution to reproduce the viscosity of blood. MDEB aggregates (25 6 6 particles, 200 lm) were released into the main branch through a 5F catheter. The phantom was tilted horizontally from 2 10 to +25 to evaluate the MRN performance. Results The gravitational force was equivalent to 71.85 mT/m in a 3T MRI. The gradient duration and amplitude had a power relationship (amplitude=78.717 ðdurationÞ À0:525 ). It was possible, in 15 elevated vascular branches, to steer 87% of injected aggregates if two MRI gradients are simultaneously activated (G x = +26.5 mT/m, G y = +18 mT/m for 57% duty cycle), the flow velocity was minimized to 8 cm/s and a residual pulsatile flow to minimize the force of friction. Conclusion Our experimental model can determine the maximum elevation angle MRN can perform in a single-bifurcation phantom simulating in vivo conditions.

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“…Various phantom manufacturing methods have been reported in the literature. The most common ones are dipping [7], dripping [20], and the use of two different molds, one for the inner and one for the outer part [21]. These approaches are invariably fraught with difficulties, especially when the geometry is complex.…”

Section: Introductionmentioning

confidence: 99%

Low-Cost Fabrication of Polyvinyl Alcohol-Based Personalized Vascular Phantoms for In Vitro Hemodynamic Studies: Three Applications

Annio

Franzetti

Bonfanti

et al. 2020

Journal of Engineering and Science in Medical Diagnostics and Therapy

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Vascular phantoms mimicking human vessels are commonly used to perform in vitro hemodynamic studies for a number of bioengineering applications, such as medical device testing, clinical simulators, and medical imaging research. Simplified geometries are useful to perform parametric studies, but accurate representations of the complexity of the in vivo system are essential in several applications as personalized features have been found to play a crucial role in the management and treatment of many vascular pathologies. Despite numerous studies employing vascular phantoms produced through different manufacturing techniques, an economically viable technique, able to generate large complex patient-specific vascular anatomies, accessible to nonspecialist laboratories, still needs to be identified. In this work, a manufacturing framework to create personalized and complex phantoms with easily accessible and affordable materials and equipment is presented. In particular, three-dimensional (3D) printing with polyvinyl alcohol (PVA) is employed to create the mold, and lost core casting is performed to create the physical model. The applicability and flexibility of the proposed fabrication protocol is demonstrated through three phantom case studies—an idealized aortic arch, a patient-specific aortic arch, and a patient-specific aortic dissection model. The phantoms were successfully manufactured in a rigid silicone, a compliant silicone, and a rigid epoxy resin, respectively; using two different 3D printers and two casting techniques, without the need of specialist equipment.

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A new production method of elastic silicone carotid phantom based on MRI acquisition using rapid prototyping technique

Cited by 13 publications

References 8 publications

Fabrication, characterization and numerical validation of a novel thin-wall hydrogel vessel model for cardiovascular research based on a patient-specific stenotic carotid artery bifurcation

Fabrication, characterization and numerical validation of a novel thin-wall hydrogel vessel model for cardiovascular research based on a patient-specific stenotic carotid artery bifurcation

Navigation of Microrobots by MRI: Impact of Gravitational, Friction and Thrust Forces on Steering Success

Low-Cost Fabrication of Polyvinyl Alcohol-Based Personalized Vascular Phantoms for In Vitro Hemodynamic Studies: Three Applications

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