A new prospect in magnetic nanoparticle-based cancer therapy: Taking credit from mathematical tissue-mimicking phantom brain models

Saeedi, Mohsen; Vahidi, Omid; Goodarzi, Vahabodin; Saeb, Mohammad Reza; Izadi, Leila; Mozafari, Masoud

doi:10.1016/j.nano.2017.07.013

Cited by 35 publications

(7 citation statements)

References 42 publications

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“…The potential of the magnetic nanoferrite family in biomedical application was already proved by several research groups working in the field of broadly understood thermo-stimulated therapies from well-known hyperthermia − stimulation of bone regenerative processes , up to a combination of localized magnetic drug delivery and a heat triggered controlled release of bioactive species , during cancer treatment. − An additional advantage of magnetic nanoparticles (MNPsespecially magnetiteFe 3 O 4 ) is that they can be also used for monitoring and evaluation of post-treatment results . Taking into account other common applications as, for example, a diagnostic tool in MRI (magnetic resonance imaging) in bioimaging of tissues, , the magnetite nanoparticles are the main component of several biomedical products accessible on the market and accepted by the FDA and EU. , …”

Section: Introductionmentioning

confidence: 99%

Energy Conversion and Biocompatibility of Surface Functionalized Magnetite Nanoparticles with Phosphonic Moieties

et al. 2020

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Magnetite nanoparticles (MNPs) were synthesized using two distinctly different approaches, co-precipitation (CP) and thermal decomposition (TD), and further surface functionalized with organophosphonic ligands containing different numbers of phosphonic groups. We have shown that it is possible to fabricate flower-like assemblies of MNPs through TD at lower temperatures, whereas CP MNPs formed agglomerates of particles with broad size distribution and irregular shapes. The effect of the organophosphonic ligands on the heating efficiency of the TD and CP MNPs under dual mode stimulation (simultaneous action of AMF and NIR laser radiation) was studied for the first time. It was found that in the case of the cost-effective CP MNP synthesis surface functionalization with chosen phosphonic ligands leads to higher heating efficiency upon laser stimulation, whereas better performance of TD MNPs was found under the action of AMF due to the significant difference of nanoparticle properties. The biocompatibility of surface functionalized MNPs with organophosphonic ligands was evaluated through thorough studies of the metabolic activity of MNPs in normal human foreskin fibroblasts as well as oxidative stress induction and oxidation stress response which has not been previously reported for most of the organophosphonic moieties used in this study.

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Section: Introductionmentioning

confidence: 99%

Energy Conversion and Biocompatibility of Surface Functionalized Magnetite Nanoparticles with Phosphonic Moieties

et al. 2020

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“…Numerous researchers are globally studying on novel biomaterials, specifically in response to tissue engineering challenges. 1,2 Tissue engineering is known to be one of the most important subjects in global health research in which careful study of the role of delicately applied biomaterials in organ reconstruction is a general way to improve human life levels. [3][4][5][6] All of the available biomaterials are categorized into two classes; synthetic and natural.…”

Section: Introductionmentioning

confidence: 99%

“…Synthesis of novel bio‐based materials has opened a new and fascinating window in the fabrication of medical utilities and devices. Numerous researchers are globally studying on novel biomaterials, specifically in response to tissue engineering challenges 1,2 . Tissue engineering is known to be one of the most important subjects in global health research in which careful study of the role of delicately applied biomaterials in organ reconstruction is a general way to improve human life levels 3–6 .…”

Section: Introductionmentioning

confidence: 99%

Green synthesis and characterization of poly(glycerol‐azelaic acid) and its nanocomposites for applications in regenerative medicine

Chenani

Rezaei

Fakhri

et al. 2021

J of Applied Polymer Sci

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A series of novel bio-polyester nanocomposites based on glycerin and azelaic acid as monomers incorporating hydroxyapatite (HA) nanoparticles were fabricated via in situ polymerization method. Chemical structure of the samples was investigated by 1 H-NMR, 13 C-NMR, and Fourier-transform infrared spectroscopy (FTIR). Energy dispersive X-ray-mapping analysis illustrated that the nanoparticles were well dispersed in the poly (glycerol azelaic acid) (PGAZ) matrix. Viscoelastic properties of the samples under various frequencies were examined in which the PGAZ specimen containing 1.0 wt% of HA nanoparticles (PGAZH1.0) exhibited superlative properties. Furthermore, the alterations in the glass transition temperature of the samples were comprehensively discussed. Thermal gravimetric analysis displayed that nanocomposites generally have a difference in degradation patterns from that of the pristine sample. Dynamic contact angle demonstrated that the presence of HA nanoparticles imposed a significant influence on hydrophilicity. The hydrolytic degradation values at pH = 7 and pH = 11 were measured and determined that the degradation rate for the PGAZ sample containing 1.5 wt% HA (PGAZH1.5) was higher than those of the other samples. Moreover, in vitro studies elucidated that cell attachment on PGAZH1.0 and PAZH1.5 surfaces were acceptable.

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“…Most of the liquid is replaced by gas. − Meanwhile, the aerogel is maintained without changing the skeleton structure of the gel. Aerogels are a kind of nanostructured materials with porosity, high specific surface area, and light weight. − Because of these excellent characteristics, aerogels have broad application prospects in many fields such as adsorption of wastewater, , thermal insulation, and nanofibrillated templates. , The characteristics of aerogels such as low density, high porosity, and high specific surface area make it suitable for many biomedical fields, such as the field of biomaterials. ,− …”

Section: Introductionmentioning

confidence: 99%

Insights into the Prospective Aerogel Scaffolds Composed of Chitosan/Aramid Nanofibers for Tissue Engineering

Jin

Yang

et al. 2022

ACS Appl. Polym. Mater.

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As an emergent interdisciplinary subject, tissue engineering is widely used in the maintenance, repair, replacement, and reconstruction of the structure and function of cartilage, blood vessels, heart, skin, and liver. Tissue engineering includes three elements: seed cells, tissue engineering scaffolds, and tissue construction. Among them, tissue engineering scaffolds, especially porous scaffolds, play an important role. The support material should have ideal physical, chemical, and mechanical properties matching with the actual application, such as specific size and shape, an appropriate pore size, and appropriate porosity and surface properties. As a kind of natural biopolymeric linear polysaccharide, chitosan (CHi) has sterling properties including being nontoxic, nonirritant, biocompatible, bacteriostatic, and excellently hydrophilic. Aramid fibers (AF) belong to a class of synthetic fibers that are thermally stable, chemically stable, and highly temperature-resistant and have low mass and a long service life. Previous studies have demonstrated that bulk AF can be effectively split into aramid nanofibers (ANFs) via dissolution in a system of dimethyl sulfoxide (DMSO)/potassium hydroxide (KOH). Composite aerogels own a three-dimensional and pore-like structure with the advantages of light weight, high porosity, and large specific surface area, which are suitable for use in the field of tissue engineering. Addressed herein is the composite aerogel synthesized from CHi and ANFs using chemical crosslinking with glutaraldehyde (GA) for a tissue engineering scaffold, named ANFs/CHi/GA. The composite was characterized using Fourier transform infrared spectroscopy and X-ray diffraction. ANFs/CHi/GA was bacteriostatic with abundant cell adhesions and a uniform cell distribution. Cytotoxicity tests prove that the composite aerogel materials are nontoxic and the cells could proliferate greatly in their leaching solutions. Cells can adhere to and distribute well on the surface of the composite aerogel material, which is suitable for use in scaffold materials.

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A new prospect in magnetic nanoparticle-based cancer therapy: Taking credit from mathematical tissue-mimicking phantom brain models

Cited by 35 publications

References 42 publications

Energy Conversion and Biocompatibility of Surface Functionalized Magnetite Nanoparticles with Phosphonic Moieties

Energy Conversion and Biocompatibility of Surface Functionalized Magnetite Nanoparticles with Phosphonic Moieties

Green synthesis and characterization of poly(glycerol‐azelaic acid) and its nanocomposites for applications in regenerative medicine

Insights into the Prospective Aerogel Scaffolds Composed of Chitosan/Aramid Nanofibers for Tissue Engineering

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