Today’s cities are becoming more and more complex, the spatial layout is gradually becoming more and more complex, and all aspects of urban construction that need to be considered are increasing. The traditional urban planning and design methods have encountered new challenges. Based on the unique perspective of urban “mesoscale,” this study attempts to apply artificial intelligence technology in the early stage of urban planning and design, predict the positioning of design land based on the surrounding environment, so as to break the limitations of manual decision-making, explore the spatial layout problem from the perspective of machine, find the correlation between land data, and generate results with certain reference value to assist decision-making. By delimiting the research area and collecting and processing data, we trained and generated the artificial neural network model and selected three different areas for model test. The test results verify the feasibility and effectiveness of the method process.