A new strategy for prevention of anastomotic stricture using tacrolimus-eluting biodegradable nanofiber

Abstract

Tacrolimus-eluting biodegradable nanofiber reduced neointimal hyperplasia and preserved endothelialization. This device may be useful in the prevention of anastomotic stricture.

A doxycycline loaded, controlled-release, biodegradable fiber for the treatment of aortic aneurysms

“…There are several reports urging the establishment of DDS using electrospinning biodegradable polymers [55e57]. We have been developing DDS using electrospinning biodegradable polymers for cardiovascular medicine [58,59]. DDS of the DCRBF is quite simple: DOXY is released with hydrolysis of the PLA, and the DCRBF appears like a cotton wool.…”

Osteogenic Induction of Bone Marrow-Derived Stromal Cells on Simvastatin-Releasing, Biodegradable, Nano- to Microscale Fiber Scaffolds

“…12 In brief, simvastatin (Toronto Research Chemicals, Inc., North York, ON, Canada) (MW = 418.57) was mixed with biodegradable polymer to fabricate SRBFS, and not mixed to fabricate BFS. Poly(L-lactide-co-glycolide) (IV = 1.15 dL/g), which consists of 50% of each polymer, was prepared for the biodegradable polymer.…”

“…2 Meanwhile, our previous studies reported a sustained drug delivery system (DDS) using electrospinning biodegradable fiber with various types of drugs. 12,13,31 Sustained drug release can be adjusted by modification in the polymer degradation and can contribute to minimizing systemic influences and adverse side effects, while maximizing the local effects. Furthermore, the electrospinning process provides engineering scaffolds with nano-to microscale topography and high porosity similar to the natural extracellular matrix (ECM).…”

Prevention of arterial graft spasm in rats using a vasodilator-eluting biodegradable nano-scaled fibre

“…We have been developing a drug-containing biodegradable nano-scaled fibre, using an electrospinning technique to achieve a local and sustained release of drugs [9][10][11]. In this study, we applied this technology for the controlled release of vasodilators to prevent arterial spasm.…”