A normative blood velocity model in the exchange microvessels for discriminating health from disease: Healthy controls versus COVID-19 cases

Koutsiaris, Aristotle G.; Riri, Konstantina; Boutlas, Stylianos; Daniil, Zoe; Tsironi, Evangelia E.

doi:10.3233/ch-231780

Cited by 3 publications

(1 citation statement)

References 48 publications

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“…Mechanisms of blood circulation disorders are a subject of interest in the study of hemodynamics [5][6][7][15][16][17]. Hemorheology also includes the analysis of blood flow abnormalities related to the changes in blood biochemical parameters in various diseases and other conditions, such as pregnancy [5][6][7][15][16][17][18]. The Fundamentals of knowledge of hemorheological parameters are increasingly used to analyze the causes and development of vascular diseases.…”

Section: Introductionmentioning

confidence: 99%

Interdependence of Rheological and Biochemical Parameters of Blood in a Group of Patients with Clinically Silent Multifocal Vascular Cerebral Lesions

Marcinkowska‐Gapińska

Siemieniak

Kawałkiewicz

et al. 2023

Biomedicines

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Background: Hemorheology is a field of science which often becomes interesting to researchers studying impairments related to blood flow disturbances. Clinically silent vascular cerebral lesions (CSVCLs) are considered a problem of great importance in neurology. Objective: This work aimed to analyze the interdependencies of the rheological and biochemical parameters of the blood. Methods: The group of patients included persons with clinically silent multifocal vascular cerebral lesions diagnosed using neuroimaging. The control group had no symptoms in the central nervous system (CNS). We analyzed hemorheological profiles in 69 patients with CSVCLs diagnosed via magnetic resonance imaging (MR) or 64-row computer tomography measurements. Rheological data were acquired using a rotary-oscillating rheometer, the Contraves LS-40, an instrument dedicated to blood viscosity measurements. For each sample, the hematocrit value was measured using the standard method. Analysis of erythrocytes’ aggregability and deformability was performed using the rheological model of Quemada. Biochemical tests of blood were also performed. Results: The results of rheological and biochemical studies were compared with those obtained in the control group. Special attention was paid to the correlation analysis of rheological and biochemical parameters. Conclusions: Such correlations were found, e.g., between the red cells’ deformability and the fibrinogen level. The results improve our understanding of blood flow hemodynamics by analyzing the shear-dependent behavior of the aggregation and deformability of red blood cells.

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Section: Introductionmentioning

confidence: 99%

Interdependence of Rheological and Biochemical Parameters of Blood in a Group of Patients with Clinically Silent Multifocal Vascular Cerebral Lesions

Marcinkowska‐Gapińska

Siemieniak

Kawałkiewicz

et al. 2023

Biomedicines

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Laser Doppler Flowmeter as a Periodontal Evaluation Method: A Clinical Pilot Study

Mateo Mediavilla,

Collado Yurrita,

Ciudad

et al. 2023

J Clin Adv Dent

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Background and objectives: Periodontal disease, as an inflammatory pathology, induces hemodynamic changes that can be evaluated by different unbiased methods such as laser Doppler flowmetry. This clinical investigation assesses laser Doppler as a non-invasive procedure to monitor gingival vascularization and its potential relationship with the response to treatment of periodontal disease. Materials & methods: 45 sites of white Spanish patients with active periodontitis undertake a complete periodontal analysis. This included periodontal pathogens identification along with the monitoring of the gingival margin microvascularization using a Doppler laser at the points exhibiting the most periodontal damage. All assessments were performed before and after periodontal combined treatment PCT (scaling, root planing, and antibiotic therapy prescription) (n = 45 sites). Results: Parameters of periodontal disease showed a positive correlation with pathogen levels. Blood flow readings decreased significantly after PCT (p < 0,05), although this parameter was not statistically correlated with periodontal nor microbial assessments in a significant range. Conclusion: Laser Doppler is a complementary method of monitoring periodontal inflammation to traditional techniques of clinical periodontal evaluation. Further studies are necessary to determine its usefulness as a predictive method of periodontal disease evolution.

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A Blood Supply Pathophysiological Microcirculatory Mechanism for Long COVID

Koutsiaris

2024

Life

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Background: The term “Long COVID” is commonly used to describe persisting symptoms after acute COVID-19. Until now, proposed mechanisms for the explanation of Long COVID have not related quantitative measurements to basic laws. In this work, a common framework for the Long COVID pathophysiological mechanism is presented, based on the blood supply deprivation and the flow diffusion equation. Methods: Case–control studies with statistically significant differences between cases (post-COVID patients) and controls, from multiple tissues and geographical areas, were gathered and tabulated. Microvascular loss (ML) was quantified by vessel density reduction (VDR), foveal avascular zone enlargement (FAZE), capillary density reduction (CDR), and percentage of perfused vessel reduction (PPVR). Both ML and hemodynamic decrease (HD) were incorporated in the tissue blood supply reduction (SR) estimation. Results: ML data were found from 763 post-COVID patients with an average VDR, FAZE, CDR, and PPVR of 16%, 31%, 14%, and 21%, respectively. The average HD from 72 post-COVID patients was 37%. The estimated SR for multiple tissues with data from 634 post-COVID patients reached a sizeable 47%. This large SR creates conditions of lower mass diffusion rates, hypoxia, and undernutrition, which at a multi-tissue level, for a long time, can explain the wide variety of the Long COVID symptoms. Conclusions: Disruption of peripheral tissue blood supply by the contribution of both ML and HD is proposed here to be the principal cause of the mechanism leading to Long COVID symptoms.

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A normative blood velocity model in the exchange microvessels for discriminating health from disease: Healthy controls versus COVID-19 cases

Cited by 3 publications

References 48 publications

Interdependence of Rheological and Biochemical Parameters of Blood in a Group of Patients with Clinically Silent Multifocal Vascular Cerebral Lesions

Interdependence of Rheological and Biochemical Parameters of Blood in a Group of Patients with Clinically Silent Multifocal Vascular Cerebral Lesions

Laser Doppler Flowmeter as a Periodontal Evaluation Method: A Clinical Pilot Study

A Blood Supply Pathophysiological Microcirculatory Mechanism for Long COVID

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