A novel amperometric glucose biosensor based on ternary gold nanoparticles/polypyrrole/reduced graphene oxide nanocomposite

Xue, Kaiwen; Zhou, Shenghai; Shi, Hongyan; Feng, Xiang; Hua, Xin; Song, Wenbo

doi:10.1016/j.snb.2014.07.018

Cited by 82 publications

(34 citation statements)

References 34 publications

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“…During the polymerization of pyrrole to form polypyrrole (either chemically or electrochemically), positive charges are created in its structure (polarons and bipolarons) [26]. Therefore, here PPy was not only used for conductive polymers, but also used as an effective linker for help in the immobilization of RGO and nanoAu on the electrode surface due to electrostatic interactions, π-π interactions [10,26,27], which contributes mechanical stability and proper conjugation to the nanohybrid composite [28]. The resulting PPy–RGO–nanoAu is expected to exhibit excellent material properties of parent components on the electrode surface, which may improve the charge transport properties, immobilization ability, and enhance signal responses due to the synergistic effect.…”

Section: Resultsmentioning

confidence: 99%

“…The acceptable stability of the biosensor could be mainly attributed to the good stability of parent components. Notably, PPy is an effective linker for help in the immobilization of RGO and nanoAu on the electrode surface [10,26,27,28]. Moreover, the RGO coating is stable as a result of its poor solubility in common solvents [38].…”

Section: Resultsmentioning

confidence: 99%

“…In this context, to date, several studies have been carried out in the area of PPy, RGO and nanoAu composites. For example, Song et al reported a nanocomposite comprised of nanoAu on the surface of RGO via facile wet-chemical routes by using PPy as a linker, and the composite exhibited excellent electrocatalytic property toward O 2 reduction [10]. Zhang et al reported an electrochemical sensor for levofloxacin based on a molecularly imprinted PPy–graphene–nanoAu modified electrode, reducing auric ions (Au 3+ ) by sodium borohydrate at 80 °C [11].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Electrochemical Synthesis of Polypyrrole, Reduced Graphene Oxide, and Gold Nanoparticles Composite and Its Application to Hydrogen Peroxide Biosensor

Zhao

Hou

et al. 2016

Nanomaterials

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Here we report a facile eco-friendly one-step electrochemical approach for the fabrication of a polypyrrole (PPy), reduced graphene oxide (RGO), and gold nanoparticles (nanoAu) biocomposite on a glassy carbon electrode (GCE). The electrochemical behaviors of PPy–RGO–nanoAu and its application to electrochemical detection of hydrogen peroxide were investigated by cyclic voltammetry. Graphene oxide and pyrrole monomer were first mixed and casted on the surface of a cleaned GCE. After an electrochemical processing consisting of the electrooxidation of pyrrole monomer and simultaneous electroreduction of graphene oxide and auric ions (Au3+) in aqueous solution, a PPy–RGO–nanoAu biocomposite was synthesized on GCE. Each component of PPy–RGO–nanoAu is electroactive without non-electroactive substance. The obtained PPy–RGO–nanoAu/GCE exhibited high electrocatalytic activity toward hydrogen peroxide, which allows the detection of hydrogen peroxide at a negative potential of about −0.62 V vs. SCE. The amperometric responses of the biosensor displayed a sensitivity of 40 µA/mM, a linear range of 32 µM–2 mM, and a detection limit of 2.7 µM (signal-to-noise ratio = 3) with good stability and acceptable reproducibility and selectivity. The results clearly demonstrate the potential of the as-prepared PPy–RGO–nanoAu biocomposite for use as a highly electroactive matrix for an amperometric biosensor.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Electrochemical Synthesis of Polypyrrole, Reduced Graphene Oxide, and Gold Nanoparticles Composite and Its Application to Hydrogen Peroxide Biosensor

Zhao

Hou

et al. 2016

Nanomaterials

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show abstract

“…Despite its advantages, RGO sheets can become aggregated and cause poor dispersion of particles attached to it. To avoid this, some materials like polypyrrole have been used as a modifier to enhance the functionality of the surface and anchor gold NPs (AuNPs) for amperometric glucose sensing [49]. A novel RGO-modified glucose sensor was developed using a Pd-Pt alloy.…”

Section: The Functions Of Mnps In Various Biosensor Typesmentioning

confidence: 99%

Noble metal nanoparticles in biosensors: recent studies and applications

Malekzad

Zangabad

Mirshekari

et al. 2017

Nanotechnology Reviews

303

119

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The aim of this review is to cover advances in noble metal nanoparticle (MNP)-based biosensors and to outline the principles and main functions of MNPs in different classes of biosensors according to the transduction methods employed. The important biorecognition elements are enzymes, antibodies, aptamers, DNA sequences, and whole cells. The main readouts are electrochemical (amperometric and voltametric), optical (surface plasmon resonance, colorimetric, chemiluminescence, photoelectrochemical, etc.) and piezoelectric. MNPs have received attention for applications in biosensing due to their fascinating properties. These properties include a large surface area that enhances biorecognizers and receptor immobilization, good ability for reaction catalysis and electron transfer, and good biocompatibility. MNPs can be used alone and in combination with other classes of nanostructures. MNP-based sensors can lead to significant signal amplification, higher sensitivity, and great improvements in the detection and quantification of biomolecules and different ions. Some recent examples of biomolecular sensors using MNPs are given, and the effects of structure, shape, and other physical properties of noble MNPs and nanohybrids in biosensor performance are discussed.

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“…Au nanoparticles (Au-NPs) has been recognized as a versatile and efficient template for the immobilization of biomolecules due to its easy preparation, relatively large surface, and good biocompatibility [28,29]. Mani et al [30] synthesized the glutathione-protected gold nanoparticles (GSH-AuNPs) pre-equipped with a functional organic layer for capturing antibody attachment, which can enhance specific bindings with biological entities.…”

Section: Introductionmentioning

confidence: 99%

Fabrication of an interferon-gamma-based ITO detector for latent tuberculosis diagnosis with high stability and lower cost

Zhang

Yan

Zhang

et al. 2015

J Solid State Electrochem

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Interferon-gamma (IFN-γ) released by T cells performs very important roles in latent diagnosis of Mycobacterium tuberculosis (MTB) infections and control of tuberculosis. In this work, a multilayer screen printing indium tin oxide (ITO) detector modified with a self-assembled graphene/ chitosan (Gr-Chit) composite film followed by glutathionemodified gold nanoparticles (GSH-AuNPs), antibodies, and antigens was fabricated for highly sensitive and rapid detection of IFN-γ. The formation of the antibody-antigen complex at the electrode surface causes the impedance to increase. Under optimum conditions, the relative increased differential pulse voltammetry (DPV) peak current values are proportional to the logarithmic value of IFN-γ concentrations in a wide range of 5 to 4000 pg/mL with a low detection limit of 0.5 pg/ mL (S/N=3). The resulting IFN-γ immunosensor shows excellent detection reproducibility, good specificity, and stability. In addition, for the detection of clinical serum samples, it is well consistent with the standard enzyme-linked immunosorbent assay (ELISA) tests. Compared to the expensive glassy carbon electrode, the ITO detector can act as a disposable electrode in clinical detection due to its low cost. This study provides a lower cost, simple, and highly sensitive approach for potential application in early diagnosis of MTB infections and control of tuberculosis.

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A novel amperometric glucose biosensor based on ternary gold nanoparticles/polypyrrole/reduced graphene oxide nanocomposite

Cited by 82 publications

References 34 publications

Electrochemical Synthesis of Polypyrrole, Reduced Graphene Oxide, and Gold Nanoparticles Composite and Its Application to Hydrogen Peroxide Biosensor

Electrochemical Synthesis of Polypyrrole, Reduced Graphene Oxide, and Gold Nanoparticles Composite and Its Application to Hydrogen Peroxide Biosensor

Noble metal nanoparticles in biosensors: recent studies and applications

Fabrication of an interferon-gamma-based ITO detector for latent tuberculosis diagnosis with high stability and lower cost

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