A novel component of the metabolic syndrome: The oxidative stress

Hopps, Eugenia; Noto, Davide; Caimi, Gregorio; Averna, Maurizio

doi:10.1016/j.numecd.2009.06.002

Cited by 317 publications

(239 citation statements)

References 45 publications

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“…The imbalance between pro-and antioxidation mechanisms observed in obesity might contribute to the pathogenesis of obesity and metabolic syndrome-associated comorbidities (6). Of note, adipose tissue-related aseptic low-grade inflammation might contribute to reduced antioxidant capacity and increase of RONS production (1,5). In addition, in this study, the baseline concentrations of TAC, a marker of antioxidation, were greater in early than that in prepubertal normal-weight and obese subjects.…”

Section: Discussionmentioning

confidence: 56%

“…Glutathione (GSH) and oxidized glutathione disulfide (GSSG), the enzymes glutathione peroxidase (GPX) and catalase and the so-called total antioxidant capacity (TAC) have been employed as markers of antioxidation (2)(3)(4). Oxidative stress in humans has been associated with obesity and resulting comorbidities (1,5,6). Childhood obesity has been associated with oxidative stress even before comorbidities occur (6,7).…”

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confidence: 99%

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Antioxidation improves in puberty in normal weight and obese boys, in positive association with exercise-stimulated growth hormone secretion

et al. 2015

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Background:Oxidative stress is associated with obesity while the evidence for the role of GH in pro-and antioxidation is inconclusive. This study investigates the relationships between growth hormone (GH), pro-and antioxidation in relation to obesity and puberty before and after an acute bout of exercise. Methods: In this case-control study, 76 healthy normalweight and obese, prepubertal and pubertal boys underwent a blood sampling before and immediately after an aerobic exercise bout until exhaustion at 70% maximal oxygen consumption. Markers of prooxidation (thiobarbituric acid reactive substances (TBARS) and protein carbonyls (PCs)) and antioxidation (glutathione (GSH), oxidized glutathione disulfide (GSSG), GSH/GSSG ratio, glutathione peroxidase (GPX), catalase, and total antioxidant capacity (TAC)) and hormones (GH, insulinlike growth factor (IGF)-1, IGF-BP-3, luteinizing hormone, follicle-stimulating hormone, and testosterone) were measured. results: Baseline and postexercise TBARS and PCs were greater, while baseline GSH, GSH/GSSG ratio, GPX, and TAC were lower in obese than that in normal-weight participants. In all participants, waist was the best negative and positive predictor for postexercise GPX and TBARS, respectively. Baseline TAC was greater in pubertal than that in pre-pubertal participants. In all participants, baseline GH was the best negative predictor for postexercise PCs. Significant positive linear correlation exists between the exercise-associated GH, and GSSG increases in pubertal normal-weight boys. conclusions: Higher prooxidation and lower antioxidation were observed in obese boys, while antioxidation improves with puberty and postexercise, paralleling GH accentuated secretion.o xidative stress defines a state of imbalance between proand antioxidation within the cell (1). Prooxidation refers to mitochondrial and nonmitochondrial mechanisms, which generate reactive oxygen and nitrogen species (RONS), whereas antioxidation refers to the adaptive activation of enzymatic and/ or nonenzymatic mechanisms, which scavenge prooxidants and their products within cells and in extracellular body fluids (1). Because the direct measurement of RONS is difficult to perform, thiobarbituric acid reactive substances (TBARS) and protein carbonyls (PCs) have been employed as markers of prooxidation (1). Glutathione (GSH) and oxidized glutathione disulfide (GSSG), the enzymes glutathione peroxidase (GPX) and catalase and the so-called total antioxidant capacity (TAC) have been employed as markers of antioxidation (2-4). Oxidative stress in humans has been associated with obesity and resulting comorbidities (1,5,6). Childhood obesity has been associated with oxidative stress even before comorbidities occur (6,7).Puberty is a maturation period in human development, when sexual characteristics and reproductive competence are developed (8). It is characterized by changes in the dynamically regulated hypothalamic-growth hormone (GH)-insulin-like growth factor (IGF)-1 and hypothalamic-pituitary-gonadal axes (9). ...

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Section: Discussionmentioning

confidence: 56%

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confidence: 99%

Antioxidation improves in puberty in normal weight and obese boys, in positive association with exercise-stimulated growth hormone secretion

et al. 2015

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“…Asian Indians have been considered to be a "high-risk population" for both MetS and CVD as the prevalence of metabolic syndrome is varied by race and ethnicity [2]. In MetS, risk of all cause mortality is increased by 1.5 folds and risk of mortality due to CVD is increased by two folds [3].…”

Section: Introductionmentioning

confidence: 99%

“…Mechanism of development of MetS is not fully understood, but hypertension, increased glucose level and dyslipidemia have been found to play role in the pathogenesis of MetS 6 . In addition, oxidative stress caused by increased free radicals constitutes the important component of pathogenesis of MetS [3].…”

Section: Introductionmentioning

confidence: 99%

A study of levels of oxidative protein modification markers AOPP and IMA with risk factors of metabolic syndrome

K¹,

Uthappa²,

Surendran

et al. 2015

Int Jour of Biomed Res

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Objective: the study was designed to look in if there was any role for protein oxidation markers [like Advanced Oxidation Protein Products (AOPP) and Ischemia Modified Albumin (IMA)] in the pathogenesis of metabolic syndrome (MetS) and effect of number of risk factors of MetS on the level of these protein oxidation markers. Method:A total of 165 (n) patients were included in the study. Patients were divided into four groups based on presence or absence of 5 cardiovascular risk factors specified in revised NCEP (rNCEP) definition for MetS. Comparisons of the examined groups were statistically analysed by the application of Student's t test. Analysis of variance (ANOVA) followed by multiple comparison post hoc Fisher test were used for the analysis of differences between the groups with different numbers of risk factors of MetS. Results: Both AOPP and IMA values significantly correlated with waist circumference, glucose, HDL-Ch and TG (p value < 0.05). AOPP and IMA values between control group and the rest of the groups showed significant difference (p value <0.05). Systolic BP however, did not show significant association with AOPP as well as with IMA (p values 0.139 and 0.083 respectively).

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“…Any aggravation of the postprandial pro-oxidative situation may have negative consequences as postprandial oxidative stress has been suggested to be the unifying mechanism in the connection between cardiovascular diseases (CVD), metabolic syndrome, insulin resistance and Type 2 diabetes [20,21]. As metabolic syndrome and CVD, both associated with a pro-oxidant situation and often with a lowered serum HDL, are an increasing problem, it is noteworthy that consuming LFME-3 products regularly increases the HDL level and reduces the oxidized LDL level [5].…”

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confidence: 99%

Proteomic proof that a probiotic elevates glutathione level in human serum

et al. 2015

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Lactobacillus fermentum ME-3 (LfME-3) has been proven to synthesize and secrete glutathione. A regular use of the foods fermented by it has shown a favourable influence on human lipid profiles and several antioxidant parameters. We administered the LfME-3-fermented kefir for 14 days to 43 human subjects and evaluated their serum with MALDI-TOF mass spectrometer at the beginning and end of the test period. We found an increase of the peak at m/z 308 (corresponding to glutathione) and a new peak at m/z 1467.

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A novel component of the metabolic syndrome: The oxidative stress

Cited by 317 publications

References 45 publications

Antioxidation improves in puberty in normal weight and obese boys, in positive association with exercise-stimulated growth hormone secretion

Antioxidation improves in puberty in normal weight and obese boys, in positive association with exercise-stimulated growth hormone secretion

A study of levels of oxidative protein modification markers AOPP and IMA with risk factors of metabolic syndrome

Proteomic proof that a probiotic elevates glutathione level in human serum

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