A novel cytocompatible, hierarchical porous Ti6Al4V scaffold with immobilized silver nanoparticles

Jia, Zhaojun; Li, Ming; Peng, Xiaoyan; Xu, Xuchen; Cheng, Yan; Zheng, Yufeng; Xi, Tingfei; Wei, Shicheng; Liu, Zhongjun

doi:10.1016/j.matlet.2015.05.084

Cited by 22 publications

(13 citation statements)

References 18 publications

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“…As a result, the resulting titanium product has improved stress-shielding effects, which may stimulate osteogenesis, thereby significantly enhancing implant-bone interface stability and reducing the risk of implant loosening (75). Furthermore, titanium with microporous structure allows better cell adhesion and increased bone in-growth to achieve biological fixation (76). 3D printing can build complex porous features inside the implant to enhance biocompatibility (77), and allows the clinician the capability to design these implants to aesthetically enhance the cosmetic outcome.…”

Section: Discussionmentioning

confidence: 99%

Application of additive manufacturing in customized titanium mandibular implants for patients with oral tumors

Xia

Feng

et al. 2020

Oncol Lett

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Section: Discussionmentioning

confidence: 99%

Application of additive manufacturing in customized titanium mandibular implants for patients with oral tumors

Xia

Feng

et al. 2020

Oncol Lett

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“…EBM, as another powder bed fusion fabrication method, also gives similar opportunities as the SLM and it can [121] process patient-specific complex designs, obtained either from the computer tomography (CT) scan of the defect site or through a CAD program. For example, in [122], Ti-6Al-4V prostheses with 3D hierarchical (macro/micro-nano) porosity were constructed by electron beam melting. In [123], the triple-and double-layered mesh Ti64-based alloy scaffolds were fabricated.…”

Section: Electron Beam Melting (Ebm)mentioning

confidence: 99%

“…The high antibacterial ability against both Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus), was demonstrated. In [122] Ti-6Al-4V prostheses with 3D hierarchical (macro/micro-/nano)porosity were constructed by electron beam melting followed by micro-arc oxidization and silver nanoparticles (AgNPs) immobilized. In another study, Ti scaffolds were produced by DMP and coated with chitosan gel (Ch), with various concentrations of AgNO 3 (Ch+Ag) via the EPD method, or biofunctionalized with vancomycin (Ch+Vanco).…”

Section: Antibacterial Effectsmentioning

confidence: 99%

Structural and Material Determinants Influencing the Behavior of Porous Ti and Its Alloys Made by Additive Manufacturing Techniques for Biomedical Applications

Dziaduszewska

Zieliński

2021

Materials

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One of the biggest challenges in tissue engineering is the manufacturing of porous structures that are customized in size and shape and that mimic natural bone structure. Additive manufacturing is known as a sufficient method to produce 3D porous structures used as bone substitutes in large segmental bone defects. The literature indicates that the mechanical and biological properties of scaffolds highly depend on geometrical features of structure (pore size, pore shape, porosity), surface morphology, and chemistry. The objective of this review is to present the latest advances and trends in the development of titanium scaffolds concerning the relationships between applied materials, manufacturing methods, and interior architecture determined by porosity, pore shape, and size, and the mechanical, biological, chemical, and physical properties. Such a review is assumed to show the real achievements and, on the other side, shortages in so far research.

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“…TNT is easily adapted to AM porous structures and can be prepared on three-dimensional nonplanar surfaces [104]. A uniform layer of TNT can be formed on porous implants by liquid phase electrochemical treatment, e.g., anodizing [105,106] and micro-arc oxidation (MAO) [107][108][109]. In addition to the macroporous structure of AM technology, the microstructure of partially melted Ti microspheres on the surface of AM implants and TNT together constitutes a unique dual micro-to nanotopography (Figure 5) [110][111][112].…”

Section: Nanometer Coatingmentioning

confidence: 99%

Toward Bactericidal Enhancement of Additively Manufactured Titanium Implants

et al. 2021

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Implant-associated infections (IAIs) are among the most intractable and costly complications in implant surgery. They can lead to surgery failure, a high economic burden, and a decrease in patient quality of life. This manuscript is devoted to introducing current antimicrobial strategies for additively manufactured (AM) titanium (Ti) implants and fostering a better understanding in order to pave the way for potential modern high-throughput technologies. Most bactericidal strategies rely on implant structure design and surface modification. By means of rational structural design, the performance of AM Ti implants can be improved by maintaining a favorable balance between the mechanical, osteogenic, and antibacterial properties. This subject becomes even more important when working with complex geometries; therefore, it is necessary to select appropriate surface modification techniques, including both topological and chemical modification. Antibacterial active metal and antibiotic coatings are among the most commonly used chemical modifications in AM Ti implants. These surface modifications can successfully inhibit bacterial adhesion and biofilm formation, and bacterial apoptosis, leading to improved antibacterial properties. As a result of certain issues such as drug resistance and cytotoxicity, the development of novel and alternative antimicrobial strategies is urgently required. In this regard, the present review paper provides insights into the enhancement of bactericidal properties in AM Ti implants.

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A novel cytocompatible, hierarchical porous Ti6Al4V scaffold with immobilized silver nanoparticles

Cited by 22 publications

References 18 publications

Application of additive manufacturing in customized titanium mandibular implants for patients with oral tumors

Application of additive manufacturing in customized titanium mandibular implants for patients with oral tumors

Structural and Material Determinants Influencing the Behavior of Porous Ti and Its Alloys Made by Additive Manufacturing Techniques for Biomedical Applications

Toward Bactericidal Enhancement of Additively Manufactured Titanium Implants

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