A novel defined pyroptosis-related gene signature for predicting the prognosis of ovarian cancer

Yang, Ying; Dai, Qinjin; Qi, Hongbo

doi:10.1038/s41420-021-00451-x

Cited by 355 publications

(373 citation statements)

References 37 publications

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“…Our research was conducted without ethical examine given that the entire data were accessible openly. Our team chose an overall 33 pyroptosis-associated genes as per past research [7,10].…”

Section: Data Collectionmentioning

confidence: 99%

“…Pyroptosis is a cell death triggered by caspase-1/4/5/11 and results in cell swelling, chromatin fragmentation ,plasma membrane cleavage, and intracellular proin ammatory release [5]. More and more studies showed that pyroptosis is vital for the cancer progress.Some previous studies reported that some key components of pyroptosis,such as in ammatory vesicles, proin ammatory cytokines ,and gasdermin proteins are closely related to tumourigenesis, invasion, and metastasis [6,7]. A few latest studies con rmed that pyroptosis play a critical role in tumour immune microenvironment and antitumour processes as well [8,9].…”

mentioning

confidence: 99%

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A Novel Pyroptosis-related Gene Signature for Prognostic Prediction of Head and Neck Squamous Cell Carcinoma

Qian

Tang

Chu

et al. 2021

Preprint

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Background: Head and neck squamous cell carcinoma (HNSCC) is an extremely heterogeneous malignant cancer with poor prognosis. Pyroptosis is defined as a novel inflammation-dependent programmed cell death. However,the pyroptosis-associated genes expression in HNSCC and their relationship with prognosis is still indistinct.Material and Methods: We acquired HNSCC patients’ mRNA expression information from TCGA and GEO publicly available. We compared tumor issues and adjacent normal tissues in terms of the gene expression, for identifying differentially expressed genes (DEGs). Based on these genes, we established a risk signature by the LASSO Cox regression in the TCGA cohort and validated in a GEO cohort. We also verified the levels of relevant mRNA expression in the model by RT-qPCR. Eventually, functional enrichment approach was carried out to explore the potential mechanisms.Results: Our team found a total of 18 differentially expressed genes (DEGs) between HNSCC and healthy sample, and 4 DEGs displayed a remarkable association with the overall survival (OS) (P< 0.05). A 4-gene signature was constructed, presenting beneficial forecast power both in TCGA and GEO cohort. Our team categorized cases into a group with high risk and another group with low risk in the light of the average risk value of the 4-gene feature. Cases in the low risk group displayed a notably greater OS compared with the high risk one (P< 0.01). The Cox regression study demonstrated the independent forecast capability of the risk score. The receiver operating characteristic approach facilitated the verification of the forecast function of the gene signature. Posterior to verification, the 4 genes were aberrantly expressed in HNSCC and healthy samples.Functional study displayed that these groups registered diverse immunity conditions. Conclusions: Pyroptosis-associated genes paly an vital role in the prognosis of HNSCC and could be an potential therapeutic target.

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“…Our research was conducted without ethical examine given that the entire data were accessible openly. Our team chose an overall 33 pyroptosis-associated genes as per past research [7,10].…”

Section: Data Collectionmentioning

confidence: 99%

mentioning

confidence: 99%

A Novel Pyroptosis-related Gene Signature for Prognostic Prediction of Head and Neck Squamous Cell Carcinoma

Qian

Tang

Chu

et al. 2021

Preprint

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“…We identi ed 4,851 and 6,513 DEGs in the LUAD and LUSC cohorts, respectively (Table S1). Subsequently, 40 and 45 pyroptosis-related genes were identi ed from the LUAD and LUSC cohorts, respectively, based on a previous review [41][42][43][44] (Table S2).…”

Section: Data Preparationmentioning

confidence: 99%

Co-expression Network and Prognosis Analyses of Pyroptosis-related Genes in Non-small Cell Lung Cancer

Liu

Zhou

et al. 2021

Preprint

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Lung cancer is very difficult to diagnose in the its early stages because of its initial asymptomatic characteristics. In recent years, pyrolysis has been shown identified as a novel type of programmed cell death with inflammation mediated by the gasdermin family. In this study, 33 differentially-expressed pyroptosis-related genes were commonly identified in both lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC) patients. Tumor-related gasdermin family genes that were significantly differentially expressed in non-small cell lung cancer (NSCLC) tissues were identified by our co-expression network analysis. Among them, the mRNA level of GSDMB gene had significant impacts on tumor staging and survival rates of NSCLC patients. Therefore, this gene is a potential new therapeutic target for the treatment of NSCLC. In addition, the high expression levels of GSDMC/D were significantly correlated with the low overall survival (OS), progression-free survival (FP) and post-progression survival (PPS) of NSCLC patients. Therefore, this gene is a potential oncogene for NSCLC. Furthermore, four small molecules (erastin, cefotiam, metanephrine, and vorinostat) that could most significantly reverse the NSCLC gene expression were identified. They interacted with GSDMB proteins mainly through H-bonds and hydrophobic interactions. This study provides new therapeutic targets and prognostic makers for NSCLC patients.

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“…The previous review contributed 33 PRGs to our research [10][11][12]. Protein-Protein Interaction Networks (PPI) of 33 PGRs were presented in Fig.…”

Section: Data Preprocessingmentioning

confidence: 99%

“…Several risk-related signaling molecules and cytokines are activated and disseminated after pyroptosis, resulting in a signi cant in ammatory cellular response and immune system activation [9]. Pyroptosis has a signi cant pro-in ammatory effect that is linked to the control of the tumor immune microenvironment, which is crucial for tumor growth [10]. Moreover, despite the fact that pyroptosis has been linked to cancer in numerous studies, the relationship between pyroptosis and anticancer immunity is still a mystery [9].…”

Section: Introductionmentioning

confidence: 99%

Development And Validation of A Pyroptosis -Related Signature And Immune Microenvironment Infiltration In Cutaneous Melanoma

Wei

Lan

Tang

et al. 2021

Preprint

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Background: Cutaneous melanoma is cancer that is both malignant and aggressive, with a poor prognosis. Pyroptosis can affect the prognosis of cancer patients by controlling tumor cell growth, migration, and metastasis, as well as is closely related to the tumor immune microenvironment. The significance of pyroptosis-related genes (PRGs) in cutaneous melanoma, however, is unknown. Methods: The training set and external validation sets were cutaneous melanoma samples from The Cancer Genome Atlas (TCGA) database and Gene Expression Omnibus (GEO), respectively. By using univariate Cox regression analysis and selection operator (Lasso) regression model, prognostic genes for overall survival (OS) were found. Candidate genes that were screened were used to calculate risk scores and construct a PRG risk model. The Kaplan Meier curve, time-dependent receiver operating characteristic (ROC) curve, and area under the curve (AUC)were used to assess the functional and prognostic usefulness of gene signatures in the risk model. Furthermore, to speculate on the activity of immune cell infiltration and immune-related pathways in the tumor immune microenvironment and calculate corresponding scores, a single sample gene set enrichment analysis (ssGSEA) was used.Results: An eight PRGs risk signature (AIM2, CASP4, CASP5, CASP8, IL18, NLRC4, NLRP6, PRKACA) were conducted and divided all cutaneous melanoma patients in the TCGA cohort into two groups: Low-risk and High-risk. Both the training and external validation sets showed that patients in the low-risk group showed a significantly higher likelihood of survival than those in the high-risk group (p < 0.001). Except for PRKACA, all the other eight PRGs in our study appeared to be longer survival times for patients. The results of ssGSEA in terms of 16 types of immune cells and the activity of 13 immune-related pathways showed that the High-risk group had lower immune pathway activity and lower levels of immune cell infiltration. In conclusion, the PRG-signature may be a significant predictor of prognosis and may play an essential role in UM patients' tumor immunity.

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A novel defined pyroptosis-related gene signature for predicting the prognosis of ovarian cancer

Cited by 355 publications

References 37 publications

A Novel Pyroptosis-related Gene Signature for Prognostic Prediction of Head and Neck Squamous Cell Carcinoma

A Novel Pyroptosis-related Gene Signature for Prognostic Prediction of Head and Neck Squamous Cell Carcinoma

Co-expression Network and Prognosis Analyses of Pyroptosis-related Genes in Non-small Cell Lung Cancer

Development And Validation of A Pyroptosis -Related Signature And Immune Microenvironment Infiltration In Cutaneous Melanoma

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