A novel mechanism involved in 5-hydroxytryptamine-induced nociception: The indirect activation of primary afferents

Role of nitric oxide/cyclic GMP/K+ channel pathways in the antinociceptive effect caused by 2,3-bis(mesitylseleno)propenol

“…Moreover, serotonin participates in the nociception induced by formalin or carrageenan (Doak and Sawynok, 1997;Okamoto et al, 2002) and induces excitation and sensitization of primary afferent fibers (Rueff and Dray, 1992). Recently, Tambeli et al (2006) demonstrated that the nociceptive effect of serotonin administered in the paw is exerted by an indirect action of serotonin in the primary afferent neurons, because this effect is attenuated by polymorphonuclear leukocyte depletion, cyclooxygenase inhibition, norepinephrine depletion from the sympathetic terminals, and by local blockade of the β 1 -or β 2 -adrenergic receptor.…”

Indirect mechanism of histamine-induced nociception in temporomandibular joint of rats

“…Also, histamine may affect nociceptors by increasing the responsiveness to 5-HT. Although 5-HT, via receptors other than 5-HT 3 receptors, may sensitize the nociceptor in addition to induce nociception, it is important to point out that the mechanisms mediating hyperalgesia are quite separate and distinct from those inducing nociception (Oliveira et al, 2007;Tambeli et al, 2006).…”

“…While the participation of histamine in the development of inflammatory pain states is not yet clear, 5-HT has been associated with both "overt pain" and hyperalgesia Tambeli et al, 2006;Oliveira et al, 2007). 5-HT may contribute to pain in TMJ disorders in humans, as the level of 5-HT is increased in patients with inflammatory disorders (Alstergren et al, 1999;Kopp, 1998), and the 5-HT 3 receptor antagonist granisetron reduces TMJ pain in humans (Voog et al, 2000).…”

Tropisetron alleviate early post‐operative pain after gynecological laparoscopy in sevoflurane based general anaesthesia: A randomized, parallel‐group, factorial study

“…Animal studies have shown that peripheral 5-HT-3A receptors induce pronociceptive effects (Lang et al, 2006). In rats, injection of 5-HT caused a dosedependent mechanical hyperalgesia sensitive to the selective 5-HT-3 blockade (Tambeli et al, 2006;Oliveira et al, 2007), and the administration of 5-HT-3 receptor agonist increased pain responses (Lang et al, 2006). Others have demonstrated that the action of 5-HT-3A receptor facilitated a dorsal horn response to Figure 2 Intraoperative haemodynamic parameters.…”