A Novel One‐Pot Synthesis of 2‐Aryl‐4(3<i>H</i>)‐Quinazolinones Using Room Temperature Ionic Liquid as Reaction Medium as well as Promoter

Potewar, Taterao M.; Nadaf, Rashid N.; Daniel, Thomas; Lahoti, R. J.; Srinivasan, Kumar

doi:10.1081/scc-200048433

Cited by 76 publications

(33 citation statements)

References 31 publications

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“…Due to green, high-tech reaction media and show excellent chemical properties [13,14], ionic liquids are receiving a lot of attention and are applied in many fields of analytical chemistry [15] such as sample preparation [16], organic synthesis [17][18][19][20], liquid-phase extraction [21,22], and chromatographic separations [23].…”

Section: Introductionmentioning

confidence: 99%

Solid-phase extraction of tanshinones from Salvia Miltiorrhiza Bunge using ionic liquid-modified silica sorbents

Tian

Yan

Row

2009

Journal of Chromatography B

109

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Section: Introductionmentioning

confidence: 99%

Solid-phase extraction of tanshinones from Salvia Miltiorrhiza Bunge using ionic liquid-modified silica sorbents

Tian

Yan

Row

2009

Journal of Chromatography B

109

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“…They are receiving great attention in many fields of analytical chemistry [12] such as sample preparation [13], organic synthesis [14][15][16][17], liquid-phase extraction [18,19], and chromatographic separations [20], because they are green reaction media with excellent chemical properties [21,22], Ionic liquid-modified materials had successfully been used in separation work because of their distinctive characteristics [23][24][25]. Some reports have been conducted on the application of these particles as the sorbent to separate some familiar organic compounds [26][27][28] and to isolate active components from natural plants [29], but the selectivity of these materials was not high.…”

Section: Introductionmentioning

confidence: 99%

SPE of Tanshinones from Salvia miltiorrhiza Bunge by using Imprinted Functionalized Ionic Liquid-Modified Silica

Tian

Row

2011

Chromatographia

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Ionic liquid-modified silica, with functional groups based on imidazole as the cation, was obtained. A molecular imprinting technique was introduced to form the order of functional groups. The selectivity of the obtained ionic liquid-modified silica was successfully used as a special imprinted sorbent in the solid-phase extraction to isolate cryptotanshinone, tanshinone I and tanshinone IIA from Salvia miltiorrhiza Bunge. Several washing and elution solvents with different polarities were evaluated. The ionic liquid-modified silica as the sorbent exhibited a higher selectivity than blank ionic liquid-modified silica, traditional silica and C 18 cartridges. A quantitative analysis was conducted by liquid chromatography with a C 18 column and methanol/water (75:25, v/v, containing 0.5% acetic acid) as the mobile phase. A good linearity was obtained from 0.5 9 10 -4 to 0.1 mg mL -1 (r 2 [ 0.99) with relative standard deviations that were less than 4.6%.

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“…Various synthetic routes are reported for synthesizing quinazolinone derivatives using starting materials like anthranilic acid, benzoxazines, anthranilates and isatoic anhydride (Wang et al, 2003;Abdel-Jalil et al, 2004;Peyman et al, 2006), yet the hunt for a convenient synthetic method is going on to improve the yield and reaction time in the on hand methods (Yi et al, 2003;Potewar et al, 2005). Among all of these, isatoic anhydride has been proved very important precursor for synthesizing 2,3-disubstituted quinazolinones under various reaction conditions (Dabiri et al, 2005;Kumari et al, 2012;Shaterian et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Synthesis, characterization and antimicrobial studies of new 2-(2-chloroquinolin-3-yl)-3-(substituted phenyl/pyridinyl)quinazolin-4(3H)-one derivatives using l-proline as a catalyst

2014

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2-(2-Chloroquinolin-3-yl)-3-(substituted phenyl/pyridinyl)quinazolin-4(3H)-one derivatives 5a-m were synthesized in good yield using conventional as well as microwave heating conditions in presence of L-proline as a catalyst. Synthetic conditions were optimized using an orthogonal array system of Taguchi's design. The structure of synthesized quinazolinone compounds 5a-m was established with the help of physico-chemical analysis and various spectroscopic techniques like FT-IR, mass, 1 H-NMR and 13 C-NMR. Further, all the synthesized compounds were screened for their antimicrobial (antibacterial, antifungal and antimalarial) activities. The results of antimicrobial screening showed that compounds 4g, 4j, 4m, 5e and 5g have good activity against bacterial species, whereas compounds 4d, 4g, 4m, 5b, 5d and 5g have good activity against malaria pathogen. In addition to this, compounds 4i, 4j and 4m exhibited good to moderate activity against fungal strains.

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A Novel One‐Pot Synthesis of 2‐Aryl‐4(3H)‐Quinazolinones Using Room Temperature Ionic Liquid as Reaction Medium as well as Promoter

Cited by 76 publications

References 31 publications

Solid-phase extraction of tanshinones from Salvia Miltiorrhiza Bunge using ionic liquid-modified silica sorbents

Solid-phase extraction of tanshinones from Salvia Miltiorrhiza Bunge using ionic liquid-modified silica sorbents

SPE of Tanshinones from Salvia miltiorrhiza Bunge by using Imprinted Functionalized Ionic Liquid-Modified Silica

Synthesis, characterization and antimicrobial studies of new 2-(2-chloroquinolin-3-yl)-3-(substituted phenyl/pyridinyl)quinazolin-4(3H)-one derivatives using l-proline as a catalyst

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