A Novel pH- and Salt-Responsive N-Succinyl-Chitosan Hydrogel via a One-Step Hydrothermal Process

Abstract

In this study, we synthesized a series of pH-sensitive and salt-sensitive N-succinyl-chitosan hydrogels with N-succinyl-chitosan (NSCS) and the crosslinker glycidoxypropyltrimethoxysilane (GPTMS) via a one-step hydrothermal process. The structure and morphology analysis of the NSCS and glycidoxypropyltrimethoxysilane-N-succinyl chitosan hydrogel (GNCH) revealed the close relation between the swelling behavior of hydrogels and the content of crosslinker GPTMS. The high GPTMS content could weaken the swelling capacity of hydrogels and improve their mechanical properties. The hydrogels show high pH sensitivity and reversibility in the range of pH 1.0 to 9.0, and exhibit on-off switching behavior between acidic and alkaline environments. In addition, the hydrogels perform smart swelling behaviors in NaCl, CaCl2, and FeCl3 solutions. These hydrogels may have great potential in medical applications.

Delivery of Mesenchymal Stem Cell in Dialdehyde Methylcellulose-Succinyl-Chitosan Hydrogel Promotes Chondrogenesis in a Porcine Model

“…Two basic characteristic peaks of the chitosan 1652 cm −1 (NH 2 deformation) and 1593 cm −1 (N–H bend) as reported in the literature [ 30 ]. After succinylation, the peak of SUC was a little bit change, two absorption peaks were appear at 1650 cm −1 and 1404 cm −1 corresponded to the formation of –CO–NH–, and the absorption peaks at 1568 cm −1 is attributed to the N–H absorption [ 19 ]. After mixing DAC and SUC solution together, we found the absorption peak at 1730 cm −1 was smaller compared with that of DAC because of the crosslinking reaction between C=O of DAC and NH 2 of SUC.…”

“…Various types of cellulose-based scaffold were developed for chondrogenesis enhancement, such as membrane [ 14 ], double network [ 15 ], oxidation [ 16 ] and electrospinning [ 17 ]. Chitosan is composed of glucosamine and N -acetylglucosamine and has a similar structure to some articular cartilage components [ 18 , 19 ]. It has limited solubility in physiological solvents because of the strong intermolecular hydrogen bonding.…”

Advances in Injectable and Self‐healing Polysaccharide Hydrogel Based on the Schiff Base Reaction

“…[62] Injecting the drug-loaded hydrogels directly to diseased positions not only bypasses the circulatory system to finish a targeting drug delivery in a minimally invasive manner but also establishes a drug reservoir at the lesions to achieve a long-term constant drug administration. [127,128] The polysaccharide hydrogels full of imine or acylhydrazone bonds possess self-healing activity which makes them reparable to mechanic damage and thus prolongs their useful life in the body. Additionally, they are pH sensitive, which accelerates their degradation and promotes drug liberation under many acidic conditions.…”

Tuning Surface Morphology of Fluorescent Hydrogels Using a Vortex Fluidic Device

“…Over decades, different crosslinking methods have been identified for the fabrication of chemically stable or degradable hydrogels for various applications [4][5][6]. Of particular interest, smart hydrogels have been extensively utilized for the sustained release of pharmaceutics with controlled pH [7][8][9], electric fields [10], osmosis [11], molecular structure [12,13], and temperature [14][15][16][17], regulating their swelling properties. In the meantime, numerous studies have been performed to improve the physical, mechanical, and biomedical properties of hydrogels, making them attractive for a wide range of applications [18,19].…”