A novel polysaccharide with antioxidant, HIV protease inhibiting and HIV integrase inhibiting activities from Fomitiporia punctata (P. karst.) murrill (Basidiomycota, hymenochaetales)

Liu, Faaang; Wang, Yinping; Zhang, Keren; Wang, Yijun; Zhou, Rong; Zeng, Yan; Han, Ya-Jie; Ng, Tzi Bun

doi:10.1016/j.ijbiomac.2017.01.030

Cited by 30 publications

(11 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It was established that the erythrocyte haemolysis inhibiting activity reflects antioxidant activity (Liu et al ., ). The citric acid‐extracted polysaccharides from Yunnan maca and the alkali‐extracted polysaccharides from black and white macas significantly protected the erythrocytes against H 2 O 2 ‐induced haemolysis at 0.5 mg mL −1 (Fig.…”

Section: Resultsmentioning

confidence: 97%

“…The effect of maca polysaccharide on DPPH and peroxyl radical scavenging might be due to hydroxyl groups which can donate hydrogen for binding with DPPH and peroxyl radicals to achieve the scavenging effect. It was established that the erythrocyte haemolysis inhibiting activity reflects antioxidant activity (Liu et al, 2017). The citric acid-extracted polysaccharides from Yunnan maca and the alkali-extracted polysaccharides from black and white macas significantly protected the erythrocytes against H 2 O 2 -induced Figure 3 Haemolysis of erythrocytes treated with water-, citric acid-and alkali-extracted polysaccharides at 0.5 mg mL À1 (a), 1 mg mL À1 (b) and 2.5 mg mL À1 (c).…”

Section: Antioxidant Activity Of Maca Polysaccharidementioning

confidence: 99%

See 1 more Smart Citation

Maca (Lepidium meyenii) as a source of macamides and polysaccharide in combating of oxidative stress and damage in human erythrocytes

Lin

Huang

Sun‐Waterhouse

et al. 2017

Int J of Food Sci Tech

View full text Add to dashboard Cite

Summary Maca is known to be rich in macamides. The objective of this study was to analyse macamide profiles of macas with different colours cultivated in Yunnan, China, and commercial Peru maca by ultra‐high‐performance liquid chromatography–tandem mass spectrometry. The antioxidant activities of water, citric acid and alkali‐extracted polysaccharides from Yunnan and Peru macas were evaluated via DPPH radical scavenging activity, oxygen radical absorbance capacity and erythrocyte haemolysis inhibition effect assays. Six major macamides present in Peru maca were also found dominant in Yunnan maca at comparable concentrations. Maca polysaccharide effectively scavenging DPPH and peroxyl radicals protected the erythrocytes against H2O2‐induced haemolysis by inhibition of malondialdehyde (MDA) generation. Citric acid extraction was found the most suitable preparation method for generating heteropolysaccharide with strong antioxidant activity. Black maca cultivated in Yunnan possessing the most abundant macamides and polysaccharide with strong antioxidant activity could be developed as functional foods.

show abstract

Section: Resultsmentioning

confidence: 97%

Section: Antioxidant Activity Of Maca Polysaccharidementioning

confidence: 99%

Maca (Lepidium meyenii) as a source of macamides and polysaccharide in combating of oxidative stress and damage in human erythrocytes

Lin

Huang

Sun‐Waterhouse

et al. 2017

Int J of Food Sci Tech

View full text Add to dashboard Cite

show abstract

“…Figure 2(b) exhibited the major functional groups and the chemical bounds of the polysaccharides. As shown, the broad absorption at 3405.03 cm −1 corresponded to the O-H stretching vibration [32], and the strong band at 2929.76 cm −1 was ascribed to stretching vibrations of C-H [33]. Two strong bands at 1639.87 and 1420.26 cm −1 were assigned to the absorbance of the deprotonated carboxylic group (COO-) [34].…”

Section: Resultsmentioning

confidence: 99%

Structural Characterization and Antitumor Activity of Polysaccharides from Kaempferia galanga L.

Yang

Feng

et al. 2018

Oxidative Medicine and Cellular Longevity

View full text Add to dashboard Cite

The water-soluble polysaccharides from Kaempferia galanga L. (KGPs) were extracted and purified, and their structural characteristics and antitumor activity were further investigated. The UV spectrum, high-performance gel permeation chromatography (HPGPC), Fourier-transform infrared spectroscopy (FTIR), and ion chromatography (IC) were employed to evaluate the structural characteristics, and H22 tumor-bearing mice model was established to demonstrate the antitumor activity. Physicochemical analysis and UV spectrum results showed that the proportions of total sugar, protein, and uronic acid in KGPs were 85.23%, 0.54%, and 24.17%, respectively. HPGPC, FTIR, and IC indicated that KGPs were acidic polysaccharides with skeletal modes of pyranose rings and mainly composed of arabinose and galactose with the average molecular weight of 8.5 × 105 Da. The in vivo antitumor experiments showed that KGPs could effectively protect the thymus and spleen of tumor-bearing mice from solid tumors and enhance the immunoregulatory ability of CD4+ T cells, the cytotoxic effects of CD8+ T cells and NK cells, and finally resulting in the inhibitory effects on H22 solid tumors. This study provided a theoretical foundation for the practical application of KGPs in food and medical industries.

show abstract

“…They act as structural elements in the cell wall (Schröder et al, 2009 ), and serve as reserve polysaccharides to feed cells and adjust osmotic potential in the walls of seed endosperm and vacuoles (Meier and Reid, 1982 ). In addition, polysaccharides of plant and fungal origins broadly manifest antioxidant activity (Wang et al, 2010 ; Liu Q. et al, 2014 ; Liu et al, 2017 ). Dendrobium plants are rich in polysaccharides.…”

Section: Discussionmentioning

confidence: 99%

High-Density Genetic Map Construction and Stem Total Polysaccharide Content-Related QTL Exploration for Chinese Endemic Dendrobium (Orchidaceae)

Liu

Xu³

et al. 2018

Front. Plant Sci.

View full text Add to dashboard Cite

Plants of the Dendrobium genus are orchids with not only ornamental value but also high medicinal value. To understand the genetic basis of variations in active ingredients of the stem total polysaccharide contents (STPCs) among different Dendrobium species, it is of paramount importance to understand the mechanism of STPC formation and identify genes affecting its process at the whole genome level. Here, we report the first high-density single-nucleotide polymorphism (SNP) integrated genetic map with a good genome coverage of Dendrobium. The specific-locus amplified fragment sequencing (SLAF-seq) technology led to identification of 7,013,400 SNPs from 1,503,626 high-quality SLAF markers from two parents (Dendrobium moniliforme ♀ × Dendrobium officinale ♂) and their interspecific F1 hybrid population. The final genetic map contained 8, 573 SLAF markers, covering 19 linkage groups (LGs). This genetic map spanned a length of 2,737.49 cM, where the average distance between markers is 0.32 cM. In total, 5 quantitative trait loci (QTL) related to STPC were identified, 3 of which have candidate genes within the confidence intervals of these stable QTLs based on the D. officinale genome sequence. This study will build a foundation up for the mapping of other medicinal-related traits and provide an important reference for the molecular breeding of these Chinese herb.

show abstract

A novel polysaccharide with antioxidant, HIV protease inhibiting and HIV integrase inhibiting activities from Fomitiporia punctata (P. karst.) murrill (Basidiomycota, hymenochaetales)

Cited by 30 publications

References 33 publications

Maca (Lepidium meyenii) as a source of macamides and polysaccharide in combating of oxidative stress and damage in human erythrocytes

Maca (Lepidium meyenii) as a source of macamides and polysaccharide in combating of oxidative stress and damage in human erythrocytes

Structural Characterization and Antitumor Activity of Polysaccharides from Kaempferia galanga L.

High-Density Genetic Map Construction and Stem Total Polysaccharide Content-Related QTL Exploration for Chinese Endemic Dendrobium (Orchidaceae)

Contact Info

Product

Resources

About