A Novel Potent Sleep‐Promoting Effect of Turmeric: Turmeric Increases Non‐Rapid Eye Movement Sleep in Mice Via Histamine H₁Receptor Blockade

Abstract

Scope: Turmeric has a broad spectrum of biological properties; however, the sleep-promoting effects of turmeric have not yet been reported. Thus, this study aims to investigate the effect of turmeric on sleep and the molecular mechanism underlying this effect. Methods and Results: Pentobarbital-induce sleep test and sleep-wake profile assessment using recorded electroencephalography are used to evaluate the hypnotic effects of the turmeric extract (TE) compared to diazepam on sleep in mice. Additionally, the molecular mechanism of TE's sleep effect is investigated using ex vivo electrophysiological recordings from brain slices in histamine H 1 receptor (H 1 R) knockout mice. Oral administration of TE and diazepam significantly reduce sleep latency and increase non-rapid eye movement sleep (NREMS) duration without delta activity in mice. Like doxepin, TE inhibits the H 1 R agonist (2-pyridylethylamine dihydrochloride)-induced increase in action potentials in the hypothalamic neurons. In animal tests using neurotransmitter agonists or antagonists, TE effect mimick H 1 R antagonistic effect of doxepin. Additionally, both reduce sleep latency and increase NREMS in wild-type mice, although these effects are not observed in H 1 R knockout mice. Conclusion: TE has a sleep-promoting effect owing to reduction in sleep latency and enhancement of NREMS via H 1 R blockade; therefore, it could be useful in insomnia.

Effect of Black Pepper (Piper nigrum) Extract on Caffeine-Induced Sleep Disruption and Excitation in Mice

“…Sleep architecture was analyzed using the method described by Um et al [ 33 ]. A head mount (Pinnacle Technology, Inc., Lawrence, KS, USA) was chronically implanted in mice under pentobarbital anesthesia (50 mg/kg) to record electroencephalogram (EEG) and electromyogram (EMG) signals.…”

Curcuminoids, a major turmeric component, have a sleep-enhancing effect by targeting the histamine H1 receptor

“…Therefore, in the present study, we investigated the constituents involved in the sleep effects of TE based on our previous results. 10 Finally, we demonstrated that curcuminoids, a major component of turmeric, decrease sleep latency and increase NREMS frequency in mice via the inhibition of the H1R.…”

“…9 In recent, it has been reported that turmeric extract (TE) exhibits sleep-promoting effects via histamine H1 receptor (H1R) blockade in animal models. 10 Oral administration of TE significantly increased non-rapid eye movement sleep (NREMS) duration and decreased sleep latency in C57BL/6N mice. These hypnotic effects were not observed in H1R knockout (KO) mice.…”

Effect of Helicobacter pylori-Associated Chronic Gastritis on Autonomous Activity and Sleep Quality in Mice

“…Notably, activation of GABAA receptor has been associated with sedative, hypnotic and anticonvulsant effects (Choi et al, 2014). Analysis of sodium pentobarbital-induced sleep is one of the most commonly used methods for detection of sleep quality in animals (Um et al, 2021). In this study, we employed this method for analysis of sleep quality in mice, and found that Hp-associated chronic gastritis caused poor sleep quality in mice, especially females.…”