A novel pulsatile blood pump design for cardiothoracic surgery: Proof‐of‐concept in a mock circulation

Weber, Elena; Chong, Albert; Liebold, Andreas; Hoenicka, Markus

doi:10.1111/aor.14436

Cited by 4 publications

(2 citation statements)

References 21 publications

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“…The VentriFlo pump attempts to mimic the cardiac cycle as closely as possible and demonstrated adequate organ perfusion without hemolysis in animal studies 24,25 . We have recently tested a novel positive displacement pump design focused on exceptionally high SHE generation 26 . Surgeons may be able to select from a range of interesting and diverse concepts for pulsatile extracorporeal perfusion in the near future.…”

Section: Discussionmentioning

confidence: 99%

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Improving adult pulsatile minimal invasive extracorporeal circulation in a mock circulation

et al. 2022

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Background: Pulsatile extracorporeal circulation (ECC) may improve perfusion of critical organs during cardiac surgery. This study analyzed the influence of the components of a minimal invasive ECC (MiECC) on the transfer of pulsatile energy into the pseudo-patient of a mock circulation.Methods: An aortic model with human-like geometry and compliance was perfused by a diagonal pump. Surplus hemodynamic energy (SHE) was determined from flow and pressure data. Five adult-size oxygenator models and three sizes of cannulas were compared. Pulsatile pump settings were optimized, and parallel dual-pump configurations were evaluated. Results:Oxygenator models showed up to twofold differences in pressure gradients and influenced SHE at flow rates up to 2.0 L min −1 . Adjustments of frequency, systole duration, and rotational speed gain significantly improved SHE compared with empirical settings, with SHE above 21% of mean arterial pressure at flow rates of 1.0 L min −1 to 1.5 L min −1 and SHE above 5% at 3.5 L min −1 . Small diameter cannula (15 Fr) limited SHE compared with larger cannula (21 Fr and 23 Fr). Two diagonal pumps did not provide higher SHE than a single pump, but permitted additional control over pulse pressure and SHE by varying the total fraction of pulsatile flow and the fraction of flow bypassing the oxygenator. Conclusions: Proper selection of components and optimizations of pump settings significantly improved pulse pressure and SHE of pulsatile MiECC.Surplus hemodynamic energy depended on flow rate with a maximum at 1.0 L min −1 -1.5 L min −1 . Pulsatile MiECC may specifically assist organ perfusion during phases of low flow.

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Section: Discussionmentioning

confidence: 99%

“…24,25 We have recently tested a novel positive displacement pump design focused on exceptionally high SHE generation. 26 Surgeons may be able to select from a range of interesting and diverse concepts for pulsatile extracorporeal perfusion in the near future.…”

Section: Discussionmentioning

confidence: 99%

Improving adult pulsatile minimal invasive extracorporeal circulation in a mock circulation

et al. 2022

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Is SHE Necessary? An Alternative Narrative

Bicknell,

Arfuso,

Chong

2024

Lecture Notes in Bioengineering

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One-shot manufacturable soft-robotic pump inspired by embryonic tubular heart

Lee,

Lee

2024

Bioinspir. Biomim.

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Soft peristaltic pumps, which use soft ring actuators instead of mechanical pistons or rollers, offer advantages in transporting liquids with non-uniform solids, such as slurry, food, and sewage. Recent advances in 3D printing with flexible thermoplastic polyurethane (TPU) present the potential for single-step fabrication of these pumps, distinguished from handcrafted, multistep traditional silicone casting methods. However, because of the relatively high hardness of TPU, TPU-based soft peristaltic pumps contract insufficiently and thus cannot perform as well as silicone-based ones. Improving the performance is crucial for fully automated, one-step manufactured soft pumps to lead to industrial use.This study aims to enhance TPU-based soft pumps through bioinspired design. Specifically, it proposed a design inspired by embryonic tubular hearts, in contrast to previous studies that mimicked digestive tracts. The new design facilitated long-axis stretching of an elliptical lumen during non-concentric contractile motion, akin to embryonic tubular hearts. The design was optimized for ring actuators and pumps 3D-printed with shore hardness 85A TPU filament. The ring actuator achieved over 99% lumen closure with the best designs. The soft pumps transported water at flow rates of up to 218 ml/min and generated a maximum discharge pressure of 355 mmHg, comparable to the performance of blood pumps used in continuous renal replacement therapy.

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A novel pulsatile blood pump design for cardiothoracic surgery: Proof‐of‐concept in a mock circulation

Cited by 4 publications

References 21 publications

Improving adult pulsatile minimal invasive extracorporeal circulation in a mock circulation

Improving adult pulsatile minimal invasive extracorporeal circulation in a mock circulation

Is SHE Necessary? An Alternative Narrative

One-shot manufacturable soft-robotic pump inspired by embryonic tubular heart

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