2011
DOI: 10.1242/dev.067306
|View full text |Cite
|
Sign up to set email alerts
|

A novel role for MuSK and non-canonical Wnt signaling during segmental neural crest cell migration

Abstract: SUMMARYTrunk neural crest cells delaminate from the dorsal neural tube as an uninterrupted sheet; however, they convert into segmentally organized streams before migrating through the somitic territory. These neural crest cell streams join the segmental trajectories of pathfinding spinal motor axons, suggesting that interactions between these two cell types might be important for neural crest cell migration. Here, we show that in the zebrafish embryo migration of both neural crest cells and motor axons is temp… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1
1

Citation Types

7
51
1

Year Published

2012
2012
2019
2019

Publication Types

Select...
7
2

Relationship

1
8

Authors

Journals

citations
Cited by 61 publications
(59 citation statements)
references
References 70 publications
7
51
1
Order By: Relevance
“…MSCs require ErbB signalling and are associated with the DRGs Our live imaging confirms that NC migration along the ventromedial path occurs in close association with the extending primary motor axons (Banerjee et al, 2011). Melanoblasts of the larval pattern also migrate along this path, as shown by the direct tracing of mitfa:gfp cells that undergo melanisation (Fig.…”
Section: Identification Of Melanophore Stem Cellssupporting
confidence: 67%
“…MSCs require ErbB signalling and are associated with the DRGs Our live imaging confirms that NC migration along the ventromedial path occurs in close association with the extending primary motor axons (Banerjee et al, 2011). Melanoblasts of the larval pattern also migrate along this path, as shown by the direct tracing of mitfa:gfp cells that undergo melanisation (Fig.…”
Section: Identification Of Melanophore Stem Cellssupporting
confidence: 67%
“…Roles of the Wnt/PCP pathway in cell migration have been reported in several different contexts [24][25][26][27][28][29][30][31][32]. In this work, blocking the Wnt/PCP pathway decreased the number of NPCs that reached the OB, without affecting their differentiation or proliferation (Figs.…”
Section: Discussionsupporting
confidence: 54%
“…Furthermore, the migration of facial branchiomotor (FBM) neurons [24][25][26][27][28][29][30][31] and neural crest cells [32] depends on the function of the PCP genes, as does neuronal morphogenesis in the postnatal hippocampus [33,34] and OB [35], indicating that PCP signaling is involved in the migration and differentiation of many types of neural cells [36][37][38]. However, the function of this signaling pathway in the postnatal migration and differentiation of neurons in the OB has not been clearly demonstrated.…”
Section: Introductionmentioning
confidence: 99%
“…Transient contacts between two colliding NC cells involve N-cadherin and lead to a local activation of the non-canonical Wnt/planar cell polarity (PCP) pathway, which in turn activates the small GTPase RhoA and inhibits Rac1, thus repolarising the cell. A role for Wnt/PCP in trunk NC cell migration has also been found in chick, zebrafish and mouse, but its connection with CIL has not been analysed (Banerjee et al, 2011;Rios et al, 2011).…”
Section: Contact Inhibition Of Locomotionmentioning
confidence: 99%