A Novel Role of Growth Differentiation Factor (GDF)-15 in Overlap with Sedentary Lifestyle and Cognitive Risk in COPD

Hirano, Tsunahiko; Doi, Keiko; Matsunaga, Kazuto; Takahashi, Shun; Donishi, Tomohiro; Suga, Kazuyoshi; Oishi, Keiji; Yasuda, Kasumi; Mimura, Yusuke; Harada, Mikihiko; Suizu, Sumiteru; Murakawa, Keita; Chikumoto, Ayumi; Ohteru, Yuichi; Matsuda, Kazuki; Uehara, Sho; Hamada, Kazuki; Ohata, Shuichiro; Murata, Yoriyuki; Yamaji, Yoshikazu; Asami‐Noyama, Maki; Edakuni, Nobutaka; Kakugawa, Tomoyuki

doi:10.3390/jcm9092737

Cited by 19 publications

(22 citation statements)

References 41 publications

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“…The Active Style Pro (HJA-750C ® , Omron Healthcare Inc., Kyoto, Japan) with triaxial acceleration can be worn around the waist and continually records physical activity for two weeks. 25 This physical activity meter has been validated 26 and widely used in healthy and elderly people 27 and patients with COPD. 28 Each participant was instructed to wear the device for at least 10 hours without sleeping while awake and to avoid water-use activities such as bath time.…”

Section: Methodsmentioning

confidence: 99%

Linguistic Validation of the Japanese Version of the Multidimensional Dyspnea Profile and Relation to Physical Activity in Patients with COPD

Kanezaki¹,

Tamaki²,

Terada³

et al. 2022

COPD

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Purpose This study aimed to develop a linguistically validated Japanese translation of the multidimensional dyspnea profile (MDP) and assess whether worsening of dyspnea’s sensory and affective domains during exercise had detrimental effects on physical activity in stable outpatients with chronic obstructive pulmonary disease (COPD). Materials and Methods The Japanese version of the MDP was prepared in collaboration with Mapi Research Trust (Lyon, France) after the approval of the developer. Physical activity was assessed using a 3-axis accelerometer. Dyspnea upon exertion was investigated using a 3-minute step test. Results The Japanese version of the MDP was obtained and validated linguistically. Air-hunger was significantly associated with total calories from walking (r = − 0.47, p < 0.05), while anxiety and depression were significantly correlated with both the amount and intensity of physical activity (r = − 0.49, p < 0.05, and r = − 0.46, p < 0.05, respectively). Conclusion The Japanese version of the MDP was suggested to reflect both pulmonary functions, ventilatory response during exercise, and intensity and amount of physical activity in patients with COPD.

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Section: Methodsmentioning

confidence: 99%

Linguistic Validation of the Japanese Version of the Multidimensional Dyspnea Profile and Relation to Physical Activity in Patients with COPD

Kanezaki¹,

Tamaki²,

Terada³

et al. 2022

COPD

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“…Elevated levels of GDF15 are associated with low muscle mass and strength, in aging patients ( 66 , 67 ). In COPD patients, it was associated with a sedentary lifestyle and cognitive risk ( 68 ). High GDF15 levels have also been associated with higher risk of ICU-acquired muscle weakness ( 69 ).…”

Section: Role Of Gdf15 In Chronic Obstructive Pulmonary Disease (Copdmentioning

confidence: 99%

Role of Growth Differentiation Factor 15 in Lung Disease and Senescence: Potential Role Across the Lifespan

et al. 2020

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Growth Differentiation Factor 15 (GDF15) is a divergent member of transforming growth factor-beta (TGF-β) superfamily and is ubiquitously expressed, under normal physiological conditions. GDF15 expression increases during many pathological states and serves a marker of cellular stress. GDF15 has multiple and even paradoxical roles within a pathological condition, as its effects can be dose- and time-dependent and vary based on the targeted tissues and downstream pathways. GDF15 has emerged as one of the most recognized proteins as part of the senescence associated secretory phenotype. Cellular senescence plays a major role in many lung diseases across the life-span from bronchopulmonary dysplasia in the premature neonate to COPD and idiopathic pulmonary fibrosis in aged adults. GDF15 levels have been reported to be as a useful biomarker in chronic obstructive pulmonary disease, lung fibrosis and pulmonary arterial hypertension and predict disease severity, decline in lung function and mortality. Glial-cell-line-derived neurotrophic factor family receptor alpha-like (GFRAL) in the brain stem has been identified as the only validated GDF15 receptor and mediates GDF15-mediated anorexia and wasting. The mechanisms and pathways by which GDF15 exerts its pulmonary effects are being elucidated. GDF15 may also have an impact on the lung based on the changes in circulating levels or through the central action of GDF15 activating peripheral metabolic changes. This review focuses on the role of GDF15 in different lung diseases across the lifespan and its role in cellular senescence.

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“…KCL has a wide application not only in Japan, but has also been translated into English, Brazilian Portuguese, Spanish, and Chinese and shown to be adequate for cross-cultural studies [29][30][31][32][33]. We categorized patient frailty status as robust (0-3), prefrail (4-7), or frail (8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25), as previously reported [34].…”

Section: Definition Of Frailty Using the Kihon Checklistmentioning

confidence: 99%

“…The frequent coexistence of frailty and COPD seems to suggest a common underlying pathophysiological mechanism [18]. Actually, patients with COPD have a greater risk for frailty than patients without COPD [19,20]. Moreover, patients with comorbid COPD and frailty have even worse outcomes (exacerbations, hospitalization, mortality, and worse quality of life) [18,[21][22][23][24][25].…”

Section: Introductionmentioning

confidence: 99%

A New Dyspnea Evaluation System Focusing on Patients’ Perceptions of Dyspnea and Their Living Disabilities: The Linkage between COPD and Frailty

Oishi

Matsunaga

Harada

et al. 2020

JCM

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Background: As much as there are unmet needs for brief frailty assessment in patients with chronic obstructive pulmonary disease (COPD), the lack of a simplified and comprehensive dyspnea evaluation system that focuses on the patients’ perceptions of dyspnea and their COPD living disabilities remains a major challenge. We developed patient-reported outcome measures for dyspnea-related behavior and activity limitation (PROMs-D), which consisted of the Activity-limit Dyspnea Scale (ADS) and Self-Limit Dyspnea Scale (SDS), while investigated the usefulness of PROMs-D in identifying frailty. Methods: We administered PROMs-D and frailty status evaluations in 128 outpatients. Results: We classified 30 (23.4%), 50 (39.0%), and 48 (37.5%) patients as robust, prefrail, and frail, respectively. There was a positive correlation between SDS and ADS (ρ = 0.67, p < 0.001), and both ADS and SDS had high accuracies for detecting frailty (AUC, 0.82 and 0.78, respectively). Moreover, a PROMs-D score that consisted of the sum of ADS and SDS was more effective in stratifying frailty (cutoff value, 2; AUC, 0.85; sensitivity, 60%; specificity, 95%). Conclusions: PROMs-D could be used as the first step for frailty screening in patients with COPD, and we propose the importance of capturing the troublesome nature of living behaviors due to dyspnea in daily clinical practice.

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A Novel Role of Growth Differentiation Factor (GDF)-15 in Overlap with Sedentary Lifestyle and Cognitive Risk in COPD

Cited by 19 publications

References 41 publications

Linguistic Validation of the Japanese Version of the Multidimensional Dyspnea Profile and Relation to Physical Activity in Patients with COPD

Linguistic Validation of the Japanese Version of the Multidimensional Dyspnea Profile and Relation to Physical Activity in Patients with COPD

Role of Growth Differentiation Factor 15 in Lung Disease and Senescence: Potential Role Across the Lifespan

A New Dyspnea Evaluation System Focusing on Patients’ Perceptions of Dyspnea and Their Living Disabilities: The Linkage between COPD and Frailty

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