A novel saliva-based microRNA biomarker panel to detect head and neck cancers

Salazar, Carolina; Nagadia, Rahul Harshad; Pandit, Pratibala; Cooper-White, Justin J.; Banerjee, Nilanjana; Dimitrova, Nevenka; Coman, William B.; Punyadeera, Chamindie

doi:10.1007/s13402-014-0188-2

Cited by 132 publications

(105 citation statements)

References 40 publications

(39 reference statements)

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“…In addition, miR-191-5p is a potential target in treating radiation-resistant lung cancer according to the study by Liu and Huang (43). Several studies also reported that miR-191-5p may be of value as a prognostic and predictive biomarker in certain tumors, including breast cancer (44), osteosarcoma (45), and head and neck squamous cell carcinoma (46). Furthermore, miR-191-5p was suggested to be a potentially non-neoplastic biomarker to diagnose traumatic brain injury and predict the patient prognosis (47).…”

Section: Discussionmentioning

confidence: 99%

MicroRNA‑191‑5p exerts a tumor suppressive role in renal cell carcinoma

et al. 2017

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Abstract. Renal cell carcinoma (RCC) is a common tumor of the urinary system. Previously, miR-191-5p has been reported to be associated with various types of cancer; however, its specific functions in RCC have not been investigated to date. In the present study, the expression of miR-191-5p in the 786-O and ACHN cell lines was detected in vitro by reverse transcription-quantitative polymerase chain reaction (RT-qPCR). The results of RT-qPCR revealed that miR-191-5p was significantly downregulated in the two cell lines compared with the 293T cell line. miR-191-5p was also significantly downregulated in RCC tissue compared with paired normal tissue. In addition, the effects of miR-191-5p on cell proliferation, migration, invasion and apoptosis were examined by CCK-8, MTT, wound scratch, Transwell and flow cytometry assays. Downregulation of miR-191-5p was observed to promote cell proliferation, migration and invasion, as well as to repress the cell apoptosis of 786-O and ACHN cells. Therefore, the current study suggests that miR-191-5p functions as a tumor suppressor in RCC. Further studies are required to uncover the underlying signaling pathway of miR-191-5p and its potential role as a biomarker for early detection and prognosis prediction, and as a therapeutic target of RCC.

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Section: Discussionmentioning

confidence: 99%

MicroRNA‑191‑5p exerts a tumor suppressive role in renal cell carcinoma

et al. 2017

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“…Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide and includes tumors of the pharynx, oral cavity and larynx [1][2][3][4]. Curcumin (diferuloylmethane), a principle ingredient in the spice turmeric, is well known for its anti-carcinogenic, antiinflammatory and pharmacological properties [5].…”

Section: Introductionmentioning

confidence: 99%

Apoptosis induction by an analog of curcumin (BDMC-A) in human laryngeal carcinoma cells through intrinsic and extrinsic pathways

et al. 2014

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“…With respect to metabolic diseases, 65 proteins are differentially expressed in the saliva of patients with type II diabetes mellitus [26]. There is potential for advancement in cancer salivary diagnostics as well; proteins, mRNA and miRNA have been shown to have distinct patterns in patients with breast cancer [27], head and neck squamous cell carcinoma [28], lung cancer [29], oral squamous cell carcinoma [30], and resectable pancreatic cancer [31] (Table 3). …”

Section: Salivary Diagnosticsmentioning

confidence: 99%

Oral Health: The Need for Both Conventional Microbial and Molecular Characterization

Friedman¹,

Alizadeh²,

Loewy³

2017

High-Throughput

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This study aims to consider the microbial distribution in oral disease, as well as gene analysis and expression, in elucidating: 1, the fundamental underpinnings of oral disease, and 2, the potential relationship between oral diseases and systemic health. A key focus is identifying the microbiota associated with oral disease manifestations characterized by both conventional microbiological and molecular methods. Variations in the observed microbial populations characterized by conventional and molecular approaches have been identified for caries, periodontitis, peri-implantitis, and stomatitis. The discovery of therapeutic approaches for oral disease will require comprehensive microbial and genomic analysis. This study evaluated the current state of the relevant microbial and genomic information for several prevalent oral diseases.

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A novel saliva-based microRNA biomarker panel to detect head and neck cancers

Abstract: We show that we have developed a reliable method to isolate miRNAs from small volumes of saliva, and that the saliva-derived miRNAs miR-9, miR-134 and miR-191 may serve as novel biomarkers to reliably detect HNSCC.

Cited by 132 publications

References 40 publications

MicroRNA‑191‑5p exerts a tumor suppressive role in renal cell carcinoma

MicroRNA‑191‑5p exerts a tumor suppressive role in renal cell carcinoma

Apoptosis induction by an analog of curcumin (BDMC-A) in human laryngeal carcinoma cells through intrinsic and extrinsic pathways

Oral Health: The Need for Both Conventional Microbial and Molecular Characterization

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