A novel sensitive and selective electrochemical sensor based on integration of molecularly imprinted with hollow silver nanospheres for determination of carbamazepine

Chen, Chunfeng; Wang, Yuanzheng; Ding, Shuhui; Hong, Chenglin; Wang, Zijun

doi:10.1016/j.microc.2019.03.024

Cited by 29 publications

(4 citation statements)

References 27 publications

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“…Carbamazepine can also spread resistant genes, resist antibiotics, and cause infections in sweat, blood, and other biological fluids. Monitoring the carbamazepine levels in health care is therefore essential [136].…”

Section: Drugsmentioning

confidence: 99%

Wearable Sensor for Continuous Sweat Biomarker Monitoring

Qiao

Chen

et al. 2022

Chemosensors

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In recent years, wearable sensors have enabled the unique mode of real-time and noninvasive monitoring to develop rapidly in medical care, sports, and other fields. Sweat contains a wide range of biomarkers such as metabolites, electrolytes, and various hormones. Combined with wearable technology, sweat can reflect human fatigue, disease, mental stress, dehydration, and so on. This paper comprehensively describes the analysis of sweat components such as glucose, lactic acid, electrolytes, pH, cortisol, vitamins, ethanol, and drugs by wearable sensing technology, and the application of sweat wearable devices in glasses, patches, fabrics, tattoos, and paper. The development trend of sweat wearable devices is prospected. It is believed that if the sweat collection, air permeability, biocompatibility, sensing array construction, continuous monitoring, self-healing technology, power consumption, real-time data transmission, specific recognition, and other problems of the wearable sweat sensor are solved, we can provide the wearer with important information about their health level in the true sense.

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Section: Drugsmentioning

confidence: 99%

Wearable Sensor for Continuous Sweat Biomarker Monitoring

Qiao

Chen

et al. 2022

Chemosensors

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“…The initial step in oxidation of CBZ involves one electron oxidation of nitrogen atom to form a radical cation. This radical happens to be in a number of resonance forms (Chen et al, 2019). The electron gets transferred to NiSe 2 from CBZ being responsible for increase in current flow through the device.…”

Section: Carbamazepine Sensing Based On I-v Studiesmentioning

confidence: 99%

Two-Dimensional Metallic NiSe2 Nanoclusters–Based Low-Cost, Flexible, Amperometric Sensor for Detection of Neurological Drug Carbamazepine in Human Sweat Samples

Veeralingam

Badhulika

2020

Front. Chem.

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Here we report a low-cost, flexible amperometric sensing platform for highly selective and sensitive detection of carbamazepine (CBZ) in human sweat samples. Detailed morphological characterization of the two-dimensional transition metal dichalcogenide NiSe 2 , synthesized using one-step hydrothermal method, confirms the formation of dense NiSe 2 nanoclusters in the range of 500-650 nm, whereas X-ray diffraction and X-ray photoelectron spectroscopy studies reveal a stable and pure cubic crystalline phase of NiSe 2. The sensor device is fabricated by uniformly depositing an optimized weight percentage of as-synthesized NiSe 2 onto flexible and biocompatible polyimide substrate using spin coating, and metal contacts are established using thermal evaporation technique. The sensor exhibits a remarkable sensitivity of 65.65 µA/nM over a wide linear range of 50 nM to 10 µM CBZ concentrations and a low limit of detection of 18.2 nM. The sensing mechanism and excellent response of NiSe 2 toward CBZ can be attributed to the highly conductive metallic NiSe 2 , large electroactive surface area of its nanoclusters, and highly interactive Ni 2+ /Ni 3+ oxidation states. Furthermore, the presence of 10-fold excess of capable interferents, such as lactic acid, glucose, uric acid, and ascorbic acid, does not affect the accurate determination of CBZ, thus demonstrating excellent selectivity. The real-time detection of CBZ is evaluated in human sweat samples using standard addition method, which yields reliable results. Furthermore, the sensor shows excellent robustness when subject to bending cycles and fast response time of 2 s. The strategy outlined here is useful in developing sensing platforms at low potential without the use of enzymes or redox binders for applications in healthcare.

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“…Therefore, these electroactive molecules can overshadow the CBZ signal in the therapeutic range, resulting in challenges with measurements in complex biofluids. Electrochemical molecular imprinting polymer (MIP) sensors, a state-of-the-art process for producing artificial biomimetic receptors, were reported with embedded signal indicators to improve the low specificity of direct detection. , Although MIP sensors are low-cost and fast, they are less selective than antibodies and have a heterogeneous distribution of binding sites . Thus, despite the numerous techniques developed for CBZ detection, there is still a need for a rapid point-of-care assay that can be run outside of a centralized lab so that treating physicians can institute rapid dosage adjustments. − …”

Section: Introductionmentioning

confidence: 99%

Electrochemical Carbamazepine Aptasensor for Therapeutic Drug Monitoring at the Point of Care

Chung

Singh

Gribkoff³

et al. 2022

ACS Omega

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Monitoring the anti-epileptic drug carbamazepine (CBZ) is crucial for proper dosing, optimizing a patient’s clinical outcome, and managing their medication regimen. Due to its narrow therapeutic window and concentration-related toxicity, CBZ is prescribed and monitored in a highly personalized manner. We report an electrochemical conformation-changing aptasensor with two assay formats: a 30 min assay for routine monitoring and a 5 min assay for rapid emergency testing. To enable “sample-to-answer” testing, a de novo CBZ aptamer (K d < 12 nM) with conformational switching due to a G-quadruplex motif was labeled with methylene blue and immobilized on a gold electrode. The electrode fabrication and detection conditions were optimized using electrochemical techniques and visualized by atomic force microscopy (AFM). The aptasensor performance, including reproducibility, stability, and interference, was characterized using electrochemical impedance spectroscopy and voltammetry techniques. The aptasensor exhibited a wide dynamic range in buffer (10 nM to 100 μM) with limits of detection of 1.25 and 1.82 nM for the 5 and 30 min assays, respectively. The clinical applicability is demonstrated by detecting CBZ in finger prick blood samples (<50 μL). The proposed assays provide a promising method to enable point-of-care monitoring for timely personalized CBZ dosing.

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A novel sensitive and selective electrochemical sensor based on integration of molecularly imprinted with hollow silver nanospheres for determination of carbamazepine

Cited by 29 publications

References 27 publications

Wearable Sensor for Continuous Sweat Biomarker Monitoring

Wearable Sensor for Continuous Sweat Biomarker Monitoring

Two-Dimensional Metallic NiSe2 Nanoclusters–Based Low-Cost, Flexible, Amperometric Sensor for Detection of Neurological Drug Carbamazepine in Human Sweat Samples

Electrochemical Carbamazepine Aptasensor for Therapeutic Drug Monitoring at the Point of Care

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