A nutrigenetic approach for investigating the relationship between vitamin B12 status and metabolic traits in Indonesian women

Surendran, Shelini; Aji, Arif Sabta; Ariyasra, Utami; Sari, Sri Rahma; Malik, Safarina G.; Tasrif, Nabila; Yani, Finny Fitry; Lovegrove, Julie A.; Sudji, Ikhwan Resmala; Lipoeto, Nur Indrawaty; Vimaleswaran, Karani Santhanakrishnan

doi:10.1007/s40200-019-00424-z

Cited by 19 publications

(25 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Thus, detecting excess adiposity and body fat composition has become particularly important to make accurate conclusions with regards to establishing causal relationships and identifying risk to prevent the onset of metabolic and cardiovascular diseases [ 62 , 63 ]. There are ethnic differences in body fat composition as we explore the complex interaction between the genes, lifestyle, and culture [ 21 ]. Understanding of ethnic differences may lead to the implementation of effective approaches to recognize and prevent metabolic diseases across different ethnic groups [ 64 ].…”

Section: Discussionmentioning

confidence: 99%

“…The MINANG study is a part of the GeNuIne (Gene-Nutrient Interactions) Collaboration, the main aim of which is to investigate the impact of gene-nutrient interactions on cardiometabolic traits using population-based data from diverse ethnic groups [ 25 , 26 ]. The methodology has been published previously [ 21 ]. In brief, one hundred and thirty-three women were recruited from community health centers in two sub districts in Padang City: Padang Timur (urban area) and Kuranji (rural area).…”

Section: Methodsmentioning

confidence: 99%

“…Since only a few studies have examined the influence of single nucleotide polymorphisms (SNPs) on 25(OH)D levels in populations within Southeast Asia, our study focused on Minangkabau women from Padang, the capital of West Sumatra. The Minangkabau ethnic group is of particular interest given that the Minangkabau people have the largest matrilineal family structure in the world where the family line is inherited from the mother’s side and where women have higher status than men in the family and society [ 21 , 22 ]. We used a genetic study to investigate the association between vitamin D status and metabolic traits in a cohort of Minangkabau women from urban and rural areas of Padang and examined whether associations were modified by environmental and dietary factors using a nutrigenetic approach.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Interaction between Vitamin D-Related Genetic Risk Score and Carbohydrate Intake on Body Fat Composition: A Study in Southeast Asian Minangkabau Women

et al. 2021

View full text Add to dashboard Cite

Metabolic diseases have been shown to be associated with low vitamin D status; however, the findings have been inconsistent. Hence, the objective of our study was to investigate the relationship between vitamin D status and metabolic disease-related traits in healthy Southeast Asian women and examine whether this relationship was modified by dietary factors using a nutrigenetic study. The study included 110 Minangkabau women (age: 25–60 years) from Padang, Indonesia. Genetic risk scores (GRS) were constructed based on five vitamin D-related single nucleotide polymorphisms (SNPs) (vitamin D-GRS) and ten metabolic disease-associated SNPs (metabolic-GRS). The metabolic-GRS was significantly associated with lower 25-hydroxyvitamin D (25(OH)D) concentrations (p = 0.009) and higher body mass index (BMI) (p = 0.016). Even though the vitamin D-GRS had no effect on metabolic traits (p > 0.12), an interaction was observed between the vitamin D-GRS and carbohydrate intake (g) on body fat percentage (BFP) (pinteraction = 0.049), where those individuals who consumed a high carbohydrate diet (mean ± SD: 319 g/d ± 46) and carried >2 vitamin D-lowering risk alleles had significantly higher BFP (p = 0.016). In summary, we have replicated the association of metabolic-GRS with higher BMI and lower 25(OH)D concentrations and identified a novel interaction between vitamin D-GRS and carbohydrate intake on body fat composition.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Interaction between Vitamin D-Related Genetic Risk Score and Carbohydrate Intake on Body Fat Composition: A Study in Southeast Asian Minangkabau Women

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Optimal vitamin B12 status is essential for women to maintain adequate maternal health and to avoid fetal developmental complications (Dror & Allen, 2012; Krishnaveni et al, 2009; Surendran et al, 2019d). Additionally, low vitamin B12 concentrations have shown negative correlations with BMI in healthy women (Baltaci et al, 2017).…”

Section: Importance Of Studying Gene–diet Interactions In Different Genetic Groupsmentioning

confidence: 99%

A nutrigenetic approach to examine the relationship between vitamin B12 status and cardio‐metabolic traits in multiple ethnic groups – findings from the GeNuIne Collaboration

Surendran

Vimaleswaran

2021

Nutrition Bulletin

Self Cite

View full text Add to dashboard Cite

Low vitamin B12 concentration has been shown to be a risk factor for cardio‐metabolic traits in numerous observational studies; however, the relationship has remained inconsistent. It is possible that certain genotypes jointly contribute to cardio‐metabolic diseases and vitamin B12 deficiency, and these may be modulated by dietary factors. The main objective of this article is to summarise the findings from the GeNuIne (Gene‐Nutrient Interactions) Collaboration on the effect of gene–nutrient interactions on vitamin B12 concentrations and cardio‐metabolic disease risk factors in population‐based studies from different ethnic groups. Interactions between vitamin B12‐related single‐nucleotide polymorphisms (SNPs) and protein energy intake (%) on waist circumference (Pinteration =0.002) and body fat percentage (Pinteraction =0.034) were observed in Sri Lankan and Indonesian populations, respectively. In the study in Brazilian adolescents, the metabolic and vitamin B12‐related SNPs showed a significant interaction with dietary carbohydrate and protein intakes on oxidised low‐density lipoprotein cholesterol and homocysteine concentrations, respectively. In the Asian Indian population, an association between obesity‐related SNPs and vitamin B12 concentrations (p = 0.018) was observed. In summary, these studies in multiple ethnic groups show that the association between genetically low vitamin B12 concentrations and cardio‐metabolic traits may be modified by dietary intake. Further studies utilising larger sample sizes are needed to confirm or refute our findings.

show abstract

“…This study is a part of the ongoing GeNuIne (gene-nutrient interactions) Collaboration, which aims to examine the interactions between genetic and dietary factors (nutrigenetics) on cardiometabolic disease and its related traits using population-based studies from several ethnic groups [20]. The methodology of the study has been published elsewhere [21]. In brief, 133 women were recruited from community health centres in two subdistricts in Padang City including Padang Timur and Kuranji districts to represent both urban and rural areas of Padang population, respectively.…”

Section: Study Participantsmentioning

confidence: 99%

Interaction between the genetic risk score and dietary protein intake on cardiometabolic traits in Southeast Asian

et al. 2020

Self Cite

View full text Add to dashboard Cite

Background Cardiometabolic diseases are complex traits which are influenced by several single nucleotide polymorphisms (SNPs). Thus, analysing the combined effects of multiple gene variants might provide a better understanding of disease risk than using a single gene variant approach. Furthermore, studies have found that the effect of SNPs on cardiometabolic traits can be influenced by lifestyle factors, highlighting the importance of analysing gene-lifestyle interactions. Aims In the present study, we investigated the association of 15 gene variants with cardiometabolic traits and examined whether these associations were modified by lifestyle factors such as dietary intake and physical activity. Methods The study included 110 Minangkabau women [aged 25–60 years and body mass index (BMI) 25.13 ± 4.2 kg/m2] from Padang, Indonesia. All participants underwent a physical examination followed by anthropometric, biochemical and dietary assessments and genetic tests. A genetic risk score (GRS) was developed based on 15 cardiometabolic disease-related SNPs. The effect of GRS on cardiometabolic traits was analysed using general linear models. GRS-lifestyle interactions on continuous outcomes were tested by including the interaction term (e.g. lifestyle factor*GRS) in the regression model. Models were adjusted for age, BMI and location (rural or urban), wherever appropriate. Results There was a significant association between GRS and BMI, where individuals carrying 6 or more risk alleles had higher BMI compared to those carrying 5 or less risk alleles (P = 0.018). Furthermore, there were significant interactions of GRS with protein intake on waist circumference (WC) and triglyceride concentrations (Pinteraction = 0.002 and 0.003, respectively). Among women who had a lower protein intake (13.51 ± 1.18% of the total daily energy intake), carriers of six or more risk alleles had significantly lower WC and triglyceride concentrations compared with carriers of five or less risk alleles (P = 0.0118 and 0.002, respectively). Conclusions Our study confirmed the association of GRS with higher BMI and further showed a significant effect of the GRS on WC and triglyceride levels through the influence of a low-protein diet. These findings suggest that following a lower protein diet, particularly in genetically predisposed individuals, might be an effective approach for addressing cardiometabolic diseases among Southeast Asian women.

show abstract

A nutrigenetic approach for investigating the relationship between vitamin B12 status and metabolic traits in Indonesian women

Cited by 19 publications

References 49 publications

Interaction between Vitamin D-Related Genetic Risk Score and Carbohydrate Intake on Body Fat Composition: A Study in Southeast Asian Minangkabau Women

Interaction between Vitamin D-Related Genetic Risk Score and Carbohydrate Intake on Body Fat Composition: A Study in Southeast Asian Minangkabau Women

A nutrigenetic approach to examine the relationship between vitamin B12 status and cardio‐metabolic traits in multiple ethnic groups – findings from the GeNuIne Collaboration

Interaction between the genetic risk score and dietary protein intake on cardiometabolic traits in Southeast Asian

Contact Info

Product

Resources

About