A NWB-based dataset and processing pipeline of human single-neuron activity during a declarative memory task

Chandravadia, Nand; Liang, Daan; Schjetnan, Andrea Gómez Palacio; Carlson, April A; Faraut, Maïlys C. M.; Chung, Jeffrey M.; Reed, Chrystal M.; Dichter, Benjamin; Maoz, Uri; Kalia, Suneil K.; Valiante, Taufik A.; Mamelak, Adam N.; Rutishauser, Ueli

doi:10.1038/s41597-020-0415-9

Cited by 12 publications

(11 citation statements)

References 19 publications

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“…We found that 13.7% of the recorded MTL units were modulated by image onset (n = 72/524; 67/524 increase; 5/524 decrease) (Figure 4B). This fraction is similar to that reported in previous studies [33]- [36], [39]. Interestingly, we found the population of neurons modulated by image-onset to be distinct from those modulated around the time of SEMs (Figure 4C).…”

Section: Saccadic Modulation Precedes Sem Onsetsupporting

confidence: 91%

“…All detected spikes were sorted using the open-source, semiautomatic template-matching algorithm OSort [38]. Similar to our previous work [39], [41], we classified clusters as putative single neurons using the following criteria (1) minimal/no violation of refractory period, (2) shape of the inter-spike interval distribution, (3) shape of the waveform, (4) separation from other clusters; and, (5) stability of firing rate (assessed by comparing the average firing rate of the neuron to multiple null distributions obtained by randomly sampling 400ms and 5s epochs from each neuron's spike train). Groups that appeared similar to one another were merged.…”

Section: Spike Detection and Sortingmentioning

confidence: 99%

“…The microelectrodes were sampled at 32kHz, with a 16-bit resolution and were bandpass filtered in hardware between 0.1 and 8kHz. Each microwire signal was re-referenced locally to one of the eight wires on the same bundle as we have done previously [39]. Electrode localization was performed by co-registering pre-op MRI with post-op CT using the iELVIS toolbox [40].…”

Section: Acquisition and Localizationmentioning

confidence: 99%

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A corollary discharge mediates saccade related inhibition of single units in mnemonic structures of the human brain

Katz

Schjetnan

Patel

et al. 2021

Preprint

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Despite the critical link between visual exploration and memory, little is known about how single-unit activity (SUA) in the human mesial temporal lobe (MTL) is modulated by saccadic eye movements (SEMs). Here we characterize SEM associated SUA modulations, unit-by-unit, and contrast them to image onset, and to occipital lobe SUA. We reveal evidence for a corollary discharge (CD)-like modulatory signal that accompanies SEMs, inhibiting/exciting a unique population of broad/narrow spiking units, respectively, before and during SEMs, and with directional selectivity. These findings comport well with the timing, directional nature, and inhibitory circuit implementation of a CD. Additionally, by linking SUA to event-related potentials (ERPs), which are directionally modulated following SEMs, we recontextualize the ERP associated with SEM as a proxy for both the strength of inhibition and saccade direction, providing a mechanistic underpinning for the more commonly recorded SEM-related ERP in the human brain.

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Section: Saccadic Modulation Precedes Sem Onsetsupporting

confidence: 91%

Section: Spike Detection and Sortingmentioning

confidence: 99%

Section: Acquisition and Localizationmentioning

confidence: 99%

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A corollary discharge mediates saccade related inhibition of single units in mnemonic structures of the human brain

Katz

Schjetnan

Patel

et al. 2021

Preprint

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“…This dataset is available on the Open Science Framework in the standardized Neurodata Without Borders format (https:// doi.org/10.17605/ OSF.IO/HV7JA). 50 ORCID Ueli Rutishauser https://orcid.org/0000-0002-9207-7069…”

Section: Conflict Of Interestmentioning

confidence: 99%

Single‐neuron correlate of epilepsy‐related cognitive deficits in visual recognition memory in right mesial temporal lobe

et al. 2021

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Objective Impaired memory is a common comorbidity of refractory temporal lobe epilepsy (TLE) and often perceived by patients as more problematic than the seizures themselves. The objective of this study is to understand what the relationship of these behavioral impairments is to the underlying pathophysiology, as there are currently no treatments for these deficits, and it remains unknown what circuits are affected. Methods We recorded single neurons in the medial temporal lobes (MTLs) of 62 patients (37 with refractory TLE) who performed a visual recognition memory task to characterize the relationship between behavior, tuning, and anatomical location of memory selective and visually selective neurons. Results Subjects with a seizure onset zone (SOZ) in the right but not left MTL demonstrated impaired ability to recollect as indicated by the degree of asymmetry of the receiver operating characteristic curve. Of the 1973 recorded neurons, 159 were memory selective (MS) and 366 were visually selective (VS) category cells. The responses of MS neurons located within right but not left MTL SOZs were impaired during high‐confidence retrieval trials, mirroring the behavioral deficit seen both in our task and in standardized neuropsychological tests. In contrast, responses of VS neurons were unimpaired in both left and right MTL SOZs. Our findings show that neuronal dysfunction within SOZs in the MTL was specific to a functional cell type and behavior, whereas other cell types respond normally even within the SOZ. We show behavioral metrics that detect right MTL SOZ‐related deficits and identify a neuronal correlate of this impairment. Significance Together, these findings show that single‐cell responses can be used to assess the causal effects of local circuit disruption by an SOZ in the MTL, and establish a neural correlate of cognitive impairment due to epilepsy that can be used as a biomarker to assess the efficacy of novel treatments.

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“…shows, despite its young age relative to the neurophysiology community, NWB 2.0 is being adopted by a growing number of diverse neuroscience laboratories and projects, creating a vibrant community where users can exchange and reuse data, with NWB as a common data standard18 .…”

mentioning

confidence: 99%

The Neurodata Without Borders ecosystem for neurophysiological data science

Rübel

Tritt

et al. 2021

Preprint

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The neurophysiology of cells and tissues are monitored electrophysiologically and optically in diverse experiments and species, ranging from flies to humans. Understanding the brain requires integration of data across this diversity, and thus these data must be findable, accessible, interoperable, and reusable (FAIR). This requires a standard language for data and metadata that can coevolve with neuroscience. We describe design and implementation principles for a language for neurophysiology data. Our software (Neurodata Without Borders, NWB) defines and modularizes the interdependent, yet separable, components of a data language. We demonstrate NWB's impact through unified description of neurophysiology data across diverse modalities and species. NWB exists in an ecosystem which includes data management, analysis, visualization, and archive tools. Thus, the NWB data language enables reproduction, interchange, and reuse of diverse neurophysiology data. More broadly, the design principles of NWB are generally applicable to enhance discovery across biology through data FAIRness.

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A NWB-based dataset and processing pipeline of human single-neuron activity during a declarative memory task

Cited by 12 publications

References 19 publications

A corollary discharge mediates saccade related inhibition of single units in mnemonic structures of the human brain

A corollary discharge mediates saccade related inhibition of single units in mnemonic structures of the human brain

Single‐neuron correlate of epilepsy‐related cognitive deficits in visual recognition memory in right mesial temporal lobe

The Neurodata Without Borders ecosystem for neurophysiological data science

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