COVID-19 illness has been recognized as an International Public Health Emergency (PHEIC). According to the World Health Organization (WHO), more than 200 countries worldwide have been impacted by the COVID-19. More than 4.7 M people in the globe have lost their lives due to the coronavirus pandemic. Governments and hospitals have taken several actions and measures to prevent the further spread of infectious diseases, protect all people, and minimize illness and death rates. Artificial Intelligence (AI) and the Internet of Things (IoT) have great potential to create prevailing tools for battling COVID-19. Several technologies such as deep learning, machine learning, natural language processing, and the Internet of Things have been used to properly address healthcare concerns, including diagnosis, drug and vaccine development, vaccine distribution, sentiment analysis, and fake news identification regarding COVID-19 reviews. The primary goal of this chapter is to focus on the potential of Artificial Intelligence (AI) and the Internet of Things (IoT). This chapter aims to provide a comprehensive overview of different approaches of AI and IoT related to combating COVID-19. In addition, the chapter discusses several actions and measurements that governments have used to prevent the spread of COVID-19. This chapter covers all methodologies applied to forecast the acceptance and the demand of the COVID-19 vaccine.