A panendoscopic approach with vital staining for tumors of the upper aerodigestive tract

Contini, Sandra; Consigli, G.F.; Lecce, Francesco Di; Casalini, Angelo Gianni; Chiapasco, Matteo; Ferrari, Giorgio

doi:10.1016/s0016-5107(88)71335-8

Cited by 2 publications

(1 citation statement)

References 4 publications

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“…TB may be useful in assessing extent of a lesion, lesion margins, and other sites of involvement not seen upon clinical examination 23, 62, 64, 66, 70, 72–78. Assessment of the margin of carcinomas was studied in 50 consecutive patients with oropharyngeal SCC who were assessed following TB application prior to resection 64.…”

Section: Biopsy Site Selectionmentioning

confidence: 99%

Utility of toluidine blue in oral premalignant lesions and squamous cell carcinoma: Continuing research and implications for clinical practice

Epstein

Sciubba²,

Silverman

et al. 2007

Head & Neck

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Toluidine blue (TB) has been shown to aid in the detection and diagnosis of oropharyngeal squamous cell carcinoma (OSCC) and oral premalignant lesions (OPLs). TB has been shown to enhance visualization of oral lesions and assist in identifying sites of increased risk of dysplastic/malignant change and promote biopsy. TB has been shown to identify lesions with molecular changes associated with risk of progression of OPLs to OSCC. A recent prospective longitudinal study showed TB retention in histologic benign lesions and lesions with mild dysplasia that are at increased risk of progression to cancer. Clinical trials show that TB is useful in identifying asymptomatic OSCC and premalignant lesions at risk of progressing to SCC, which might otherwise be undetected until lesions become more advanced. The data supports TB use in oral examination of patients at risk of OSCC.

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