A Panoramic Review on Lepidium sativum L. Bioactives as Prospective Therapeutics

Ahmad, Ausaf; Nabi, Rabia; Mishra, Anuradha; Ahmad, Iffat Zareen

doi:10.1055/a-1334-4101

Cited by 8 publications

(7 citation statements)

References 32 publications

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“…The plant's anatomical parts, especially the seeds, exert their effects. Some research was performed on animal models to assess the healing properties of graden cress, and it was noticed that garden cress increased collagen deposition and tensile strength at the fracture sites and radiologically accelerated callus development in rabbits (Ahmad et al., 2021 ; Bin Abdullah Juma & Martin, 2011 ).…”

Section: Biological Activitiesmentioning

confidence: 99%

Garden cress seeds: a review on nutritional composition, therapeutic potential, and industrial utilization

Tufail,

Khan,

Bader Ul Ain

et al. 2024

Food Science & Nutrition

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The growing preference for natural remedies has resulted in increased use of medicinal plants. One of the most significant and varied plants is garden cress (Lepidium sativum), which has large concentrations of proteins, fatty acids, minerals, and vitamins. It also contains a wide range of bioactive components, including kaempferol glucuronide, gallic acid, protocatechuic acid, coumaric acid, caffeic acid, terpenes, glucosinolates, and many more. These substances, which include antioxidant, thermogenic, depurative, ophthalmic, antiscorbutic, antianemic, diuretic, tonic, laxative, galactogogue, aphrodisiac, rubefacient, and emmengogue qualities, add to the medicinal and functional potential of garden cress. An extensive summary of the phytochemical profile and biological activity of garden cress seeds is the main goal of this review. Research showed that garden cress is one of the world's most underutilized crops, even with its nutritional and functional profile. Consequently, the goal of this review is to highlight the chemical and nutritional makeup of Lepidium sativum while paying particular attention to its bioactive profile, various health claims, therapeutic benefits, and industrial applications.

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Section: Biological Activitiesmentioning

confidence: 99%

Garden cress seeds: a review on nutritional composition, therapeutic potential, and industrial utilization

Tufail,

Khan,

Bader Ul Ain

et al. 2024

Food Science & Nutrition

View full text Add to dashboard Cite

show abstract

“…Additionally, seeds had anti-diarrheal, anti-hypertensive, antidiabetic, antioxidant, diuretic, anti-carcinogenic properties 23,24 25 , anti-bacterial, cardio-protective 26 , anti-hypercholesterolemia 27,28 , anti-fungal, anti-osteoporotic and anti-inflammatory property 29 . Garden cress seed also have an ability to protect liver from toxicity and cancer 30 . Studies have too shown that L.…”

Section: Health Benefits Of Lepidium Sativummentioning

confidence: 99%

Health Benefits of Garden Cres Seeds

Abid,

Basharat,

Arshad

et al. 2022

Riphah j. allied health sci.

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Lepidium sativum is one of the therapeutic plants which is broadly cultivated in Asia, Australia, Africa, Northern, Europe, and Southern America, also known as garden cress and halim seed. Garden cress seed contained carbohydrates (35 to 54%), fat (14 to 26%), protein (27%), and fiber (8%). Garden cress seed had a significant quantity of calcium, phosphorus, iron, folic acid, vitamins A and C. Garden cress seed is known to consume as a stimulant for immune system, in treatment of anemia and also possess antidiarrheal, antidiabetic, antihypertensive, diuretic, antioxidant, anti-carcinogenic, anti-hypercholesterolemia, anti-osteoporosis, antibacterial, antifungal, anti-inflammatory. It also involves in contraction of heart and limbs muscle, and accelerate fracture healing. Hence, consumption of garden cress seed not only fulfil nutritional needs of body but also effective in the treatment of many health conditions.

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“…In addition to volatile oils, the leaves and seeds of this plant are rich in minerals, amino acids and fatty acids [ 37 , 39 ]. There is 33–54% carbohydrates in seeds, 25% protein, 14–24% lipids and 8% crude fibre in seeds [ 40 , 41 ]. LS has been reported for treatment of several disorders [ 42 , 43 , 44 ].…”

Section: Introductionmentioning

confidence: 99%

Changes in Pharmacokinetics and Pharmacodynamics of Losartan in Experimental Diseased Rats Treated with Curcuma longa and Lepidium sativum

et al. 2022

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The current study investigated “pharmacodynamics and pharmacokinetics interactions” of losartan with Curcuma longa (CUR) and Lepidium sativum (LS) in hypertensive rats. Hypertension was induced by oral administration of L-NAME (40 mg/kg) for two weeks. Oral administration of CUR or LS shows some substantial antihypertensive activity. The systolic blood pressure (SBP) of hypertensive rats was decreased by 7.04% and 8.78% 12 h after treatment with CUR and LS, respectively, as compared to rats treated with L-NAME alone. LS and CUR display the ability to potentiate the blood pressure-lowering effects of losartan in hypertensive rats. A greater decrease in SBP, by 11.66% and 13.74%, was observed in hypertensive rats treated with CUR + losartan and LS + losartan, respectively. Further, both the investigated herbs, CUR and LS, caused an increase in plasma concentrations of losartan in hypertensive rats. The AUC0-t, AUC0-inf and AUMC0-inf of losartan were increased by 1.25-fold, 1.28-fold and 1.09-fold in hypertensive rats treated with CUR + losartan. A significant (p < 0.05) increase in AUC0-t (2.41-fold), AUC0-inf (3.86-fold) and AUMC0-inf (8.35-fold) of losartan was observed in hypertensive rats treated with LS + losartan. The present study affirms that interactions between CUR or LS with losartan alter both “pharmacokinetics and pharmacodynamics” of the drug. Concurrent administration of losartan with either CUR or LS would require dose adjustment and intermittent blood pressure monitoring for clinical use in hypertensive patients. Additional investigation is necessary to determine the importance of these interactions in humans and to elucidate the mechanisms of action behind these interactions.

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A Panoramic Review on Lepidium sativum L. Bioactives as Prospective Therapeutics

Cited by 8 publications

References 32 publications

Garden cress seeds: a review on nutritional composition, therapeutic potential, and industrial utilization

Garden cress seeds: a review on nutritional composition, therapeutic potential, and industrial utilization

Health Benefits of Garden Cres Seeds

Changes in Pharmacokinetics and Pharmacodynamics of Losartan in Experimental Diseased Rats Treated with Curcuma longa and Lepidium sativum

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