Computational methods have been used to simulate hemodynamics for several decades now. However, the field has experienced a remarkable advancement in the past 20 years, due to concurrent breakthroughs in medical imaging and computer hardware and software. It is now possible to create sophisticated patient‐specific models of hemodynamics to study cardiovascular disease, test the performance of medical devices, perform noninvasive diagnostics, and even virtually plan complex surgeries. In this chapter, we provide an overview of classic, well‐established methods for blood flow modeling and a summary of novel computational tools. We then review several salient clinical applications in which computational modeling has had a prominent role in the past few years and end the chapter with the discussion of current challenges and future opportunities.