A Perspective on the Evolution of the Coronary Circulation in Fishes and the Transition to Terrestrial Life

Farrell, Anthony P.; Farrell, Nicole; Jourdan, H.; Cox, Georgina

doi:10.1007/978-1-4614-3387-3_4

Cited by 41 publications

(61 citation statements)

References 78 publications

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“…This extends earlier findings of Ca4 protein expression in rainbow trout hearts and absence in gills (Georgalis et al, 2006), and of membraneassociated CA in the hearts of cyclostomes (Esbaugh and Tufts, 2004;Esbaugh et al, 2009) that are completely avascular (Farrell et al, 2012).…”

Section: Discussionsupporting

confidence: 89%

“…venous return contained in the lumen of cardiac chambers). Very few teleost fish have a coronary supply to the entire myocardium, and the hearts of at least one-third of teleosts are completely devoid of coronary vessels (Davie and Farrell, 1991;Tota et al, 1983;Farrell et al, 2012). Oxygen diffusion from the cardiac circulation into the myocardium depends on the partial pressure gradient of oxygen in the venous blood (PV O2 ) that can decrease substantially after burst exercise (Farrell and Clutterham, 2003) and during environmental hypoxia (Holeton and Randall, 1967).…”

Section: Introductionmentioning

confidence: 99%

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Evidence for a plasma-accessible carbonic anhydrase in the lumen of salmon heart that may enhance oxygen delivery to the myocardium

Alderman

Harter

Wilson

et al. 2016

Journal of Experimental Biology

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Oxygen supply to the heart of most teleosts, including salmonids, relies in part or in whole on oxygen-depleted venous blood. Given that plasma-accessible carbonic anhydrase (CA) in red muscle of rainbow trout has recently been shown to facilitate oxygen unloading from arterial blood under certain physiological conditions, we tested the hypothesis that plasma-accessible CA is present in the lumen of coho salmon (Oncorhynchus kisutch) hearts, and may therefore assist in the luminal oxygen supply to the spongy myocardium, which has no coronary circulation. We demonstrate a widespread distribution of CA throughout the heart chambers, including lumen-facing cells in the atrium, and confirm that the membrane-bound isoform ca4 is expressed in the atrium and ventricle of the heart. Further, we confirm that CA catalytic activity is available to blood in the atrial lumen using a modified electrometric ΔpH assay in intact atria in combination with either a membrane-impermeable CA inhibitor or specific cleavage of the Ca4 membrane anchor. Combined, these results support our hypothesis of the presence of an enhanced oxygen delivery system in the lumen of a salmonid heart, which could help support oxygen delivery when the oxygen content of venous blood becomes greatly reduced, such as after burst exercise and during environmental hypoxia.

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Section: Discussionsupporting

confidence: 89%

Section: Introductionmentioning

confidence: 99%

Evidence for a plasma-accessible carbonic anhydrase in the lumen of salmon heart that may enhance oxygen delivery to the myocardium

Alderman

Harter

Wilson

et al. 2016

Journal of Experimental Biology

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“…51). This is also supported by recent molecular phylogenetic analyses suggesting that perciforms lack a coronary vasculature (27). Specifically, we used surgically implanted oxygen optodes and blood flow probes to study the relationship between cardiac oxygenation, cardiovascular performance, and CT max during a thermal ramping protocol.…”

mentioning

confidence: 59%

Cardiac oxygen limitation during an acute thermal challenge in the European perch: effects of chronic environmental warming and experimental hyperoxia

Ekström

Brijs

Clark

et al. 2016

American Journal of Physiology-Regulatory, Integrative and Comp

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“…Large, fast‐swimming and predatory fish, such as trout, usually possess extensive coronary vessels, whereas zebrafish are neither large nor predator, and therefore have a lower oxygen demand on the heart (Farrell et al. ).…”

Section: Discussionmentioning

confidence: 99%

Unravelling the blood supply to the zebrafish pharyngeal jaws and teeth

Crucke

Huysseune

2013

Journal of Anatomy

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We describe the vascular supply to the pharyngeal jaws and teeth in zebrafish, from larval stages to juveniles, using serial high quality semithin sections and 3D reconstructions. We have identified that the arterial blood supply to the last pair of branchial arches, which carries the teeth, issues from the hypobranchial artery. Surprisingly, the arteries supplying the pharyngeal jaws show an asymmetric branching pattern that is modified over ontogeny. Moreover, the blood vessel pattern that serves each jaw can best be described as a sinusoidal cavity encircling the bases of both the functional and replacement teeth. Capillaries branching from this sinusoidal cavity enter the pulp and constitute the intrinsic blood supply to the attached teeth. The role of these blood vessels during tooth development (whether instructive or nutritive) remains to be determined and requires further study. However, we have provided a firm morphological basis that will aid in the interpretation of experiments addressing this question.

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A Perspective on the Evolution of the Coronary Circulation in Fishes and the Transition to Terrestrial Life

Cited by 41 publications

References 78 publications

Evidence for a plasma-accessible carbonic anhydrase in the lumen of salmon heart that may enhance oxygen delivery to the myocardium

Evidence for a plasma-accessible carbonic anhydrase in the lumen of salmon heart that may enhance oxygen delivery to the myocardium

Cardiac oxygen limitation during an acute thermal challenge in the European perch: effects of chronic environmental warming and experimental hyperoxia

Unravelling the blood supply to the zebrafish pharyngeal jaws and teeth

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